ChemicalBook > CAS DataBase List > (+)-FANGCHINOLINE

(+)-FANGCHINOLINE

Product Name
(+)-FANGCHINOLINE
CAS No.
436-77-1
Chemical Name
(+)-FANGCHINOLINE
Synonyms
Hanfangchin B（Fangchinoline）;(+)-limacine;Tetrandrine B;FANGCHINO-LINE;Hanfangichin B;Fangchinoline-RM;(+)-FANGCHINOLINE;FANGCHINOLINE (RG);7-o-demethyltetrandrine;12-O-MethylatherosperMoline
CBNumber
CB6221346
Molecular Formula
C37H40N2O6
Formula Weight
608.72
MOL File
436-77-1.mol
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(+)-FANGCHINOLINE Property

Melting point:
240～242℃
Boiling point:
709.7±60.0 °C(Predicted)
Density 
1.204±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Soluble in chloroform and methanol;
pka
9.38±0.20(Predicted)
form 
powder to crystal
color 
White to Orange to Green
Water Solubility 
slightly soluble in water
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Safety

HS Code 
2939.79.0000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1173
Product name
Fangchinoline
Packaging
20MG
Price
$75
Updated
2024/03/01
TCI Chemical
Product number
F1173
Product name
Fangchinoline
Packaging
100MG
Price
$226
Updated
2024/03/01
Cayman Chemical
Product number
29243
Product name
Fangchinoline
Packaging
5mg
Price
$60
Updated
2024/03/01
Cayman Chemical
Product number
29243
Product name
Fangchinoline
Packaging
10mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
29243
Product name
Fangchinoline
Packaging
50mg
Price
$315
Updated
2024/03/01
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(+)-FANGCHINOLINE Chemical Properties,Usage,Production

Description

A bisbenzylisoquino!ine alkaloid obtained from Limacia cuspidata (Miers.) Hook. f. et Thorn., the base crystallizes from Me2CO in the form of long, colourless needles. It is strongly laevorotatory with [α]D - 2120 (CHCI3) and has been shown to be the optical antipode of fanchinoline (q.v.).

Description

Fangchinoline is an alkaloid that has been found in S. tetrandrae and has diverse biological activities, including anti-inflammatory, neuroprotective, and anticancer properties. It inhibits the activity of sheep COX and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells with IC50 values of 129 and 3.7 μM, respectively. Fangchinoline (1 and 10 μM) reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons. It decreases proliferation of PC3 human prostate cancer cells by 63 and 86% when used at concentrations of 20 and 30 μM, respectively. Fangchinoline reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 5 mg/kg per day for 12 days.

Uses

(+)-Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.

Definition

ChEBI: A bisbenzylisoquinoline alkaloid that is (1beta)- berbaman which has been substituted by methyl groups at the 2 and 2' positions, by methoxy groups at the 6, 6', and 12 positions, and by a hydroxy group at position 7. Isolated from S ephania tetrandra, it has been found to possess neuroprotective and anti-tumour activity.

References

Tomita, Furukawa., Tetrahedron Lett., 4293 (1966)

(+)-FANGCHINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (+)-FANGCHINOLINE manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
(+)-FANGCHINOLINE 436-77-1
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
Hebei Mojin Biotechnology Co., Ltd
Product
(+)-FANGCHINOLINE 436-77-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-16
Shanghai Standard Technology Co., Ltd.
Product
Fangchinoline 436-77-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-09

436-77-1, (+)-FANGCHINOLINERelated Search:

D-Tetrandrine veratramine Daurinoline VERATRINE ISOTETRANDRINE menisdaurin Xanthiside ISOCOLUMBIN Indigo Musk ketone Polysaccharide Protocatechualdehyde FORSYTHIN Glabridin Magnolia officinalis P.E. 7-O-isopropyl fangchinoline FANGCHINOLINE >90% BY HPLC 7-O-ethyl fangchinoline

  • FANGCHINOLINE (RG)
  • Hanfangchin B（Fangchinoline）
  • FANGCHINOLINE; HANFANGCHIN B
  • 12-O-MethylatherosperMoline
  • Tetrandrine B
  • Fangchinoline, 98%, from Stephania tetrandra S. Moore
  • (+)-limacine
  • (1-beta)-2,2’-dimethyl-6,6’,12-trimethoxyberbaman-7-ol
  • 2’-dimethyl-6,6’,12-trimethoxy-(1-beta)-berbaman-7-o
  • 7-o-demethyltetrandrine
  • 6,6',12-TRIMETHOXY-2,2'-DIMETHYLBERBAMAN-7-OL
  • (+)-FANGCHINOLINE
  • FANGCHINO-LINE
  • Fangchinoline, Demethyltetrandrine
  • Hanfangichin B
  • Berbaman-7-ol,6,6',12-trimethoxy-2,2'-dimethyl-, (1β)-
  • (1S)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol
  • (1S)-7-Hydroxy-6,6',12-trimethoxy-2,2'-dimethylberbaman
  • 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol, 3,4,4a,5,16a,17,18,19-octahydro-12,21,26-trimethoxy-4,17-dimethyl-, (4aS,16aS)-
  • (+)-FANGCHINOLINE USP/EP/BP
  • (11S,31S)-16,36,54-Trimethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphan-37-ol
  • 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol,3,4,4a,5,16a,17,18,19-octahydro-12,21,26-trimethoxy-4,17-dimethyl-,(4aS,16aS)-
  • Fangchinoline-RM
  • 436-77-1
  • C37H48N2O6
  • reference substance
  • Alkaloids