Organic Intermediate
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6-Bromohexanoic acid

Organic Intermediate
Product Name
6-Bromohexanoic acid
CAS No.
4224-70-8
Chemical Name
6-Bromohexanoic acid
Synonyms
Hexanoic acid, 6-bromo-;6-bromohexanoate;ISBO-007;AKOS BB/0098;6-BroMhexine acid;6-bromo-hexanoicaci;6-BroMhexanoic acid;6-BROMOCAPROIC ACID;RARECHEM AL BO 0317;6-bromohexonic acid
CBNumber
CB6221568
Molecular Formula
C6H11BrO2
Formula Weight
195.05
MOL File
4224-70-8.mol
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6-Bromohexanoic acid Property

Melting point:
32-34 °C (lit.)
Boiling point:
165-170 °C/20 mmHg (lit.)
Density 
1.3996 (rough estimate)
refractive index 
1.4790 (estimate)
Flash point:
154 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
methanol: 0.1 g/mL, clear, colorless
pka
4.72±0.10(Predicted)
form 
Low Melting Crystals
color 
White to light orange
BRN 
1749740
InChIKey
NVRVNSHHLPQGCU-UHFFFAOYSA-N
LogP
1.700 (est)
CAS DataBase Reference
4224-70-8(CAS DataBase Reference)
NIST Chemistry Reference
Hexanoic acid, 6-bromo-(4224-70-8)
EPA Substance Registry System
Hexanoic acid, 6-bromo- (4224-70-8)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45-28A
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
F 
8
Hazard Note 
Corrosive/Harmful
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29159080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
150452
Product name
6-Bromohexanoic acid
Purity
97%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
150452
Product name
6-Bromohexanoic acid
Purity
97%
Packaging
25g
Price
$74
Updated
2024/03/01
TCI Chemical
Product number
B1290
Product name
6-Bromohexanoic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$64
Updated
2024/03/01
TCI Chemical
Product number
B1290
Product name
6-Bromohexanoic Acid
Purity
>98.0%(GC)(T)
Packaging
250g
Price
$361
Updated
2024/03/01
Alfa Aesar
Product number
A15761
Product name
6-Bromohexanoic acid, 98+%
Packaging
25g
Price
$65.65
Updated
2024/03/01
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6-Bromohexanoic acid Chemical Properties,Usage,Production

Organic Intermediate

6-bromohexanoic acid(CAS:4224-70-8), also called 6-bromohexanoic acid or 6-bromo-hexanoic acid, is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis. Here, we introduced a method for making this compound.

Chemical Properties

White to light orange low melting crystals

Uses

Employed in a direct preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278)1 and alkyl ketones from alkyl iodides and metallic strontium.2

Uses

6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis.

Uses

6-Bromohexanoic acid was used in the preparation of N-acylsulfonamides on treatment with tosyl isocyanate (189278) and alkyl ketones from alkyl iodides and metallic strontium. It was also used in the synthesis of anionic mitomycin C-dextran conjugate (MMC-D), 2-lithio-1,3-dithian and diaryl thioethers.

Definition

ChEBI: 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It is functionally related to a hexanoic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 5137, 1950 DOI: 10.1021/ja01167a091

Synthesis

The preparation method of the high purity 6-bromocaproic acid: the exsiccant bromize hydrogen gas is directly fed contain in the organic solvent of 6-caprolactone, exsiccant bromize hydrogen gas usage quantity is 6-caprolactone 1.0-2.0 doubly (mol ratio); Stir, ring-opening reaction takes place, temperature of reaction is 0 ℃ ~ 100 ℃, generates high purity 6-bromocaproic acid.

6-Bromohexanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

5-CARBOXY-1-PENTANETHIOL Ethyl 6-bromohexanoate
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6-Bromohexanoic acid Suppliers

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View Lastest Price from 6-Bromohexanoic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
6-Bromohexanoic acid 4224-70-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg/month
Release date
2021-12-27
Hebei Weibang Biotechnology Co., Ltd
Product
6-Bromohexanoic acid 4224-70-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
6-Bromohexanoic acid 4224-70-8
Price
US $20.00-2.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-15

4224-70-8, 6-Bromohexanoic acidRelated Search:

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  • 6 - broMine caproic acid
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  • 6-BromohexanoicAcid98+%
  • 6-bromohexanoate
  • 6-Bromohexanoic Acid &gt
  • 6-Bromohexanoic acid 4224-70-8
  • ethylenedioxythiophene
  • 4224-70-8
  • BrCH2CH24COOH
  • BrCH25CO2H
  • 蠅-Bromocarboxylic Acids
  • 蠅-Functional Alkanols, Carboxylic Acids, Amines & Halides
  • C6
  • Carbonyl Compounds
  • Carboxylic Acids
  • Building Blocks
  • CARBOXYLIC ACID
  • Organic Building Blocks
  • C6
  • Carbonyl Compounds
  • Carboxylic Acids
  • Chemical Synthesis
  • Organic Building Blocks
  • omega-Functional Alkanols, Carboxylic Acids, Amines & Halides
  • Aliphatics
  • Miscellaneous Reagents
  • Building Blocks
  • Organic acids
  • Acids & Esters
  • Bromine Compounds
  • omega-Bromocarboxylic Acids