ChemicalBook > CAS DataBase List > 1,3-Dithiane

1,3-Dithiane

Product Name
1,3-Dithiane
CAS No.
505-23-7
Chemical Name
1,3-Dithiane
Synonyms
1,3-Dithian;M-DITHIANE;1,3-DITHIANE;Dithiane-1,3;1,3-Dithane;META-DITHIANE;1,3-Dithiane>1,3-Dithiane,97%;1,3-Dithiane,99%;1,3-Dithiane,98%
CBNumber
CB6223805
Molecular Formula
C4H8S2
Formula Weight
120.24
MOL File
505-23-7.mol
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1,3-Dithiane Property

Melting point:
52-54 °C (lit.)
Boiling point:
207-208°C
Density 
1.062 (estimate)
refractive index 
1.5981 (estimate)
Flash point:
195 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
Crystals, Needles or Powder
pka
31(at 25℃)
color 
White to pale beige
Odor
at 0.01 % in propylene glycol. alliaceous roasted
Odor Type
alliaceous
Water Solubility 
Soluble in benzene, ether, chloroform and terahydrofuran. Slightly soluble in water.
Sensitive 
Hygroscopic
BRN 
102534
InChIKey
WQADWIOXOXRPLN-UHFFFAOYSA-N
LogP
1.729 (est)
CAS DataBase Reference
505-23-7(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Dithiane(505-23-7)
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Safety

Risk Statements 
20/21/22
Safety Statements 
22-24/25
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
RTECS 
JO5070000
F 
13
HazardClass 
4.1
PackingGroup 
III
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
157872
Product name
1,3-Dithiane
Purity
97%
Packaging
5g
Price
$54.6
Updated
2024/03/01
TCI Chemical
Product number
D0119
Product name
1,3-Dithiane
Purity
>97.0%(GC)
Packaging
5g
Price
$69
Updated
2024/03/01
TCI Chemical
Product number
D0119
Product name
1,3-Dithiane
Purity
>97.0%(GC)
Packaging
25g
Price
$214
Updated
2024/03/01
Alfa Aesar
Product number
A10505
Product name
1,3-Dithiane, 98%
Packaging
5g
Price
$47.65
Updated
2024/03/01
Alfa Aesar
Product number
A10505
Product name
1,3-Dithiane, 98%
Packaging
25g
Price
$160.65
Updated
2024/03/01
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1,3-Dithiane Chemical Properties,Usage,Production

Chemical Properties

white to pale beige crystals, needles or powder

Uses

1,3-Dithiane is used in umpolung reactions such as the Corey-Seebach reaction. It acts as a reagent for the deoxygenation of sulfoxides to their corresponding sulfides. Further, it is used as a protecting group for carbonyl compounds used in organic synthesis. It serves as a useful labeled synthon. In addition to this, it is used in the preparation of 2-ethyl-[1,3]dithiane.

Definition

ChEBI: 1,3-dithiane is a dithiane.

Reactions

1,3-dithiane has 2 weakly acidic protons that can be removed and alkylation of the carbon is possible. Once alkylated, the 1,3-dithiane becomes a “protected” carbonyl as it can be hydrolyzed to the corresponding carbonyl structure. Alternatively, the 1,3-dithiane moiety may also be introduced by thioacetalisation of a carbonyl group, either using acid or Lewis acid catalysis, 12 or of a 1,1-dihalide (using transition metal catalysis).

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 4477, 1988 DOI: 10.1016/S0040-4039(00)80527-4

General Description

1,3-Dithiane, a protected formaldehyde anion equivalent, serves as useful labeled synthon.

Purification Methods

Crystallise the 1,3-dithiane from 1.5 times its weight of MeOH at 0o, and sublime it at 40-50o/0.1mm. [Groel & Seebach Synthesis 357 1977, Beilstein 19/1 V 13.]

1,3-Dithiane Preparation Products And Raw materials

Raw materials

Potassium hydroxide solution Acetic acid Dimethoxymethane

Preparation Products

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1,3-Dithiane Suppliers

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View Lastest Price from 1,3-Dithiane manufacturers

JINING XINHE CHEMICAL CO., LTD
Product
1,3-Dithiane 505-23-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10ton
Release date
2024-07-15
Career Henan Chemical Co
Product
1,3-Dithiane 505-23-7
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
ask
Release date
2018-12-22

505-23-7, 1,3-DithianeRelated Search:

2,1,3-Benzothiadiazole N,N-Dimethyldodecylamine 2-Mercapto-5-methyl-1,3,4-thiadiazole 1,4-Dioxane Hexamethyldisilazane 2,2'-ETHYLENEBIS(1,3-DITHIANE) 2-TRIMETHYLSILYL-1,3-DITHIANE 2-PHENYL-1,3-DITHIANE 4-(1,3-Dithian-2-yl)benzonitrile, 97% 2-METHYL-1,3-DITHIANE m-Dithiane-2-carboxylic acid, ethyl ester 2-ISOBUTYL-1,3-DITHIANE 2-(3,4-Dimethoxyphenyl)-N-(3,4-dimethoxyphenethyl)-N-methyl-1,3-dithiane-2-propan-1-amine 1,1,3,3-tetraoxide 2,5-Dihydroxy-1,4-dithiane trans-1,2-Dithiane-4,5-diol, Oxidized DTT 1,4-Dithiane Dimeric mercapto propanone BIS(1,3-DITHIAN-2-YL)METHANE

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  • M-DITHIANE
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  • 1,3-Dithiane,98%
  • 1,3-Dithiane,99%
  • META-DITHIANE
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