2-Chloro-4-fluorobenzyl bromide

Product Name: 2-Chloro-4-fluorobenzyl bromide
CAS No.: 45767-66-6
Chemical Name: 2-Chloro-4-fluorobenzyl bromide
Synonyms: TIMTEC-BB SBB005762;2-choro-4-fluorobenzylbromide;bromo-2-chloro-4-fluorotoluene;2-CHLORO-4-FLUOROBENZYL BROMIDE;à-bromo-2-chloro-4-fluorotoluene;2-Chloro-4-fluorobenzyl bromide,99%;2-Chloro-4-fluorobenzyl Bromide >ALPHA-BROMO-2-CHLORO-4-FLUOROTOLUENE;2-Chloride-4-Fluoride Bromine Benzyl;(2-chloro-4-fluorophenyl)methyl bromide
CBNumber: CB6225713
Molecular Formula: C7H5BrClF
Formula Weight: 223.47
MOL File: 45767-66-6.mol

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2-Chloro-4-fluorobenzyl bromide Property

Melting point:: 33-35°C
Boiling point:: 226.8±25.0 °C(Predicted)
Density: 1.3879 (rough estimate)
refractive index: 1.5550 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: soluble in Methanol
form: Crystalline Low Melting Mass
color: White to yellow
Sensitive: Lachrymatory
BRN: 3539265
InChI: InChI=1S/C7H5BrClF/c8-4-5-1-2-6(10)3-7(5)9/h1-3H,4H2
InChIKey: GAUUDQVOPUKGJD-UHFFFAOYSA-N
SMILES: C1(CBr)=CC=C(F)C=C1Cl
CAS DataBase Reference: 45767-66-6(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xn
Risk Statements: 34-22
Safety Statements: 45-36/37/39-26
RIDADR: 3265
Hazard Note: Corrosive/Lachrymatory
HazardClass: 8
PackingGroup: III
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2098
Product name: 2-Chloro-4-fluorobenzyl Bromide
Purity: >98.0%(GC)
Packaging: 5g
Price: $40
Updated: 2024/03/01

TCI Chemical

Product number: C2098
Product name: 2-Chloro-4-fluorobenzyl Bromide
Purity: >98.0%(GC)
Packaging: 25g
Price: $117
Updated: 2024/03/01

TRC

Product number: C584688
Product name: 2-Chloro-4-fluorobenzyl Bromide
Packaging: 500mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C584688
Product name: 2-Chloro-4-fluorobenzyl Bromide
Packaging: 1g
Price: $55
Updated: 2021/12/16

TRC

Product number: C584688
Product name: 2-Chloro-4-fluorobenzyl Bromide
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

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2-Chloro-4-fluorobenzyl bromide Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-4-fluorobenzyl bromide is used as a reagent in the synthesis of a variety of compounds, such as pharmaceuticals, agrochemicals, and industrial chemicals.

Synthesis

452-73-3

45767-66-6

General procedure for the synthesis of 2-chloro-4-fluorobenzyl bromide from 2-chloro-4-fluorotoluene: A mixture of 77.6 g (0.54 mol) of 2-chloro-4-fluorotoluene, 95.6 g (0.54 mol) of N-bromosuccinimide, 1 g of benzoyl peroxide, and 1,000 mL of carbon tetrachloride was heated and refluxed for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered through a G3 glass sand core funnel. The precipitate was washed with 3 x 100 mL of carbon tetrachloride. The filtrates were combined and concentrated to dryness under reduced pressure. The residue was purified by fractional distillation and the fractions with boiling points of 97-99 °C/10 mmHg were collected to give pure 2-chloro-4-fluorobenzyl bromide in a yield of 106 g (88% yield). Elemental analysis (C7H5BrClF) Calculated values: C, 37.62; H, 2.26; measured values: C, 37.79; H, 2.34. 1H NMR (CDCl3) δ: 7.41 (dt, J = 8.4 Hz, 6.0 Hz, 1H, 6-H), 7.13 (dt, J = 8.4 Hz, 2.6 Hz, 1H, 3-H), and 6.97 (dt, J = 8.4 Hz, 2.6 Hz, 1H, 5-H), 4.55 (s, 2H, CH2).

References

[1] Patent: WO2007/70041, 2007, A1. Location in patent: Page/Page column 115
[2] Journal of Organic Chemistry, 1983, vol. 48, # 4, p. 526 - 532
[3] Patent: US2007/135595, 2007, A1

2-Chloro-4-fluorobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-4-fluorobenzyl bromide Suppliers

Americas 1 Belgium 2 China 172 Europe 1 France 2 Germany 5 India 4 Italy 1 Japan 5 Jordan 1 Switzerland 1 Ukraine 1 United Kingdom 14 United States 34 Global 244

Huangshi Jingchi?Medicine?Co.,?Ltd

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View Lastest Price from 2-Chloro-4-fluorobenzyl bromide manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-4-fluorobenzyl bromide 45767-66-6
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%
Supply Ability: 2000tons
Release date: 2020-01-16

Career Henan Chemical Co

Product: 2-Chloro-4-fluorobenzyl bromide 45767-66-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-10

45767-66-6, 2-Chloro-4-fluorobenzyl bromideRelated Search:

2-(Trifluoromethyl)benzyl chloride 2-Chlorobenzyl chloride Chlorobromoisocyanurate Allyl bromide BCDMH Benzyl bromide Sodium bromate alpha-Chloro-o-fluorotoluene Rocuronium bromide Benzyl chloroformate Ethidium bromide 4-Nitrobenzyl bromide Methyl bromide Difluorochloromethane 2-Chlorobenzyl bromide 2-Chloro-4-fluorotoluene 2-CHLORO-4,5-DIFLUOROBENZYL BROMIDE 3-Fluorobenzyl bromide

à-bromo-2-chloro-4-fluorotoluene

2-Chloro-4-fluorobenzyl bromide,99%

2-choro-4-fluorobenzylbromide

2-Chloro-4-fluorobenzyl broMide, 99% 2.5GR

2-Chloro-4-fluorobenzyl broMide, 99% 25GR

1-(Bromomethyl)-2-chloro-4-fluorobenzene, alpha-Bromo-2-chloro-4-fluorotoluene

(2-chloro-4-fluorophenyl)methyl bromide

bromo-2-chloro-4-fluorotoluene

TIMTEC-BB SBB005762

ALPHA-BROMO-2-CHLORO-4-FLUOROTOLUENE

2-CHLORO-4-FLUOROBENZYL BROMIDE

1-(BROMOMETHYL)-2-CHLORO-4-FLUOROBENZENE

2-Chloride-4-Fluoride Bromine Benzyl

2-Chloro-4-fluorobenzyl Bromide &gt

Benzene, 1-(bromomethyl)-2-chloro-4-fluoro-

45767-66-6

445767-66-6

BENZYL HALIDE

Fluorine series