N'-NITROSONORNICOTINE

Product Name: N'-NITROSONORNICOTINE
CAS No.: 16543-55-8
Chemical Name: N'-NITROSONORNICOTINE
Synonyms: NNN;(2S)-N’nitrosonornicotine;N-NITROSONORNICOTINE;1’-nitrosonornicotine;N'-NITROSONORNICOTINE;-Nitrosonornicotine-d4;N-nitroso nicotine (NNN);(S)-N’-Nitrosonornicotine;(2S)-N'-Nitrosonornicotine
CBNumber: CB6227878
Molecular Formula: C9H11N3O
Formula Weight: 177.2
MOL File: 16543-55-8.mol

More

Less

N'-NITROSONORNICOTINE Property

Melting point:: 47.1°C
Boiling point:: 309.13°C (rough estimate)
Density: 1.1669 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 5.16±0.12(Predicted)
color: Off-White to Pale Beige
Stability:: Stable, but air and light sensitive. Incompatible with oxidizing agents.
InChI: InChI=1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2/t9-/m0/s1
InChIKey: XKABJYQDMJTNGQ-VIFPVBQESA-N
SMILES: N(N1CCC[C@H]1C1=CN=CC=C1)=O
IARC: 1 (Vol. Sup 7, 89, 100E) 2012
EPA Substance Registry System: N-Nitrosonornicotine (16543-55-8)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-40
Safety Statements: 26-36
RIDADR: 2810
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 16543-55-8(Hazardous Substances Data)
Toxicity: LD50 intraperitoneal in mouse: 1gm/kg

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N-075
Product name: (±)-N′-Nitrosonornicotine (NNN) solution
Purity: 1.0?mg/mLinmethanol,ampuleof1?mL,certifiedreferencematerial,Cerilliant?
Packaging: 1mL
Price: $149
Updated: 2025/07/31

TRC

Product number: N535001
Product name: (2S)-N’-Nitrosonornicotine
Packaging: 10mg
Price: $185
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: D34102
Product name: N?-Nitrosonornicotine-d4
Packaging: 5mg
Price: $1250
Updated: 2021/12/16

More

Less

N'-NITROSONORNICOTINE Chemical Properties,Usage,Production

Description

A nicotine alkaloid, this base has been detected in some Japanese cigarette tobaccos and also in Kirsu tobacco where it occurs in the fresh leaves that have been dried without fermentation. From these two sources it has been isolated at 1.1 and 1. 8 ppm levels respectively

Chemical Properties

white crystals

Uses

A tobacco alkaloid as risk factor of human cancer.

General Description

White crystalline flakes or yellow oil that solidifies on standing in the cold.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A nitrated amine, nicotine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition it may emit toxic and hazardous fumes of NOx and COx.

Fire Hazard

Flash point data for N'-NITROSONORNICOTINE are not available; however, N'-NITROSONORNICOTINE is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Low toxicity by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Carcinogenicity

N-Nitrosonornicotine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

References

Bharadwaj et al., Gann., 66, 585 (1975)

N'-NITROSONORNICOTINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N'-NITROSONORNICOTINE Suppliers

Canada 2 China 38 Europe 1 Germany 1 India 2 Norway 1 South Korea 1 United Kingdom 2 United States 6 Global 54

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4511
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shenzhen Newcore Chemical Technology Co., Ltd.

Tel: 13612807752
Email: ncchemical@163.com
Country: China
ProdList: 290
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3811
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7924
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886766 13927870850
Fax: 0751-2886756
Email: 3001267247@qq.com
Country: China
ProdList: 9941
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038 18502138905
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9611
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10945
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 29668
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9968
Advantage: 58

Bejing Famous Pharmaceutical Technology Co., Ltd.

Tel: 15811073878
Email: 2559355526@qq.com
Country: China
ProdList: 10701
Advantage: 58

Scinova Biotech(Guangzhou) Co., Ltd.

Tel: 13268215580
Email: scinova_sales@163.com
Country: China
ProdList: 7025
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Shanghai isotope chemical co.,ltd

Tel: 021-51600108 13062666369
Email: sales@isotopechem.com
Country: China
ProdList: 5000
Advantage: 58

Abosyn

Tel: 0512-69561983 13914027025
Email: he_qf@medinoah.com
Country: China
ProdList: 3001
Advantage: 58

https://www.shachemlin.cn/

Tel: 021-68080707 18079794756
Email: soloman.lee@chemlin.com.cn
Country: China
ProdList: 8480
Advantage: 58

Shenzhen Xingyue Biotechnology Co., Ltd

Tel: 18124513697; 18124513697
Fax: 18822823697
Email: jjj18822823697@163.com
Country: China
ProdList: 1377
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Shanghai Aitixi Biotechnology Co., Ltd

Tel: 18721763493
Email: 2493172863@qq.com
Country: China
ProdList: 979
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Nanjing bojida Pharmaceutical Technology Co., Ltd

Tel: 18762407961
Email: 704079339@qq.com
Country: China
ProdList: 1380
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Shanxi Tihondan Pharmaceutical Technology Co., Ltd

Tel: +8618235132063
Email: sales@tihondan.com
Country: China
ProdList: 3767
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

16543-55-8, N'-NITROSONORNICOTINERelated Search:

1’-demethyl-1’-nitroso-nicotin

1’-desmethyl-1’-nitrosonicotine

1’-nitroso-1’-demethyl-nicotin

1’-nitroso-1’-demethylnicotine

1’-nitrosonornicotine

1-nitroso-2-(3-pyridyl)pyrrolidine

nitrosonornicotine

-Nitrosonornicotine-d4

(2S)-N&rsquo

(S)-3-(1-Nitrosopyrrolidin-2-yl)pyridine

NNN

N'-NITROSONORNICOTINE

N-NITROSONORNICOTINE

(2S)-N'-Nitrosonornicotine

(S)-3-(1-Nitroso-2-pyrrolidinyl)pyridine

Pyridine, 3-[(2S)-1-nitroso-2-pyrrolidinyl]-

N-nitroso nicotine (NNN)

(S)-N’-Nitrosonornicotine

16543-55-8

808508-23-2

Aromatics

Chiral Reagents

Heterocycles

Nicotine Derivatives