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N-NITROSOPYRROLIDINE

Product Name
N-NITROSOPYRROLIDINE
CAS No.
930-55-2
Chemical Name
N-NITROSOPYRROLIDINE
Synonyms
NPYR;NPY1R;NPYY1;n-pyr;NPY1-R;No-Pyr;n-n-pyr;NSC 18797;Nitrosopyrrolidine;N-nitropyrrolidine
CBNumber
CB8684002
Molecular Formula
C4H8N2O
Formula Weight
100.12
MOL File
930-55-2.mol
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N-NITROSOPYRROLIDINE Property

Boiling point:
214 °C(lit.)
Density 
1.085 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.489(lit.)
Flash point:
182 °F
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Sparingly), Ethyl Acetate, Methanol (Slightly)
form 
Oil
pka
-3.14±0.20(Predicted)
color 
Pale Yellow to Yellow
CAS DataBase Reference
930-55-2(CAS DataBase Reference)
IARC
2B (Vol. 17, Sup 7) 1987
EPA Substance Registry System
N-Nitrosopyrrolidine (930-55-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
40
RIDADR 
2810
WGK Germany 
3
RTECS 
UY1575000
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
930-55-2(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 900 mg/kg (Druckrey)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

Precautionary statements

P281Use personal protective equipment as required.

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N-Bromosuccinimide Price

TRC
Product number
N545950
Product name
1-Nitrosopyrrolidine
Packaging
1g
Price
$55
Updated
2021/12/16
Usbiological
Product number
487129
Product name
NPY1R
Packaging
100ul
Price
$529
Updated
2021/12/16
Biorbyt Ltd
Product number
orb597102
Product name
NPY1R
Packaging
10μg
Price
$290.7
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0006919
Product name
1-NITROSOPYRROLIDINE
Purity
95.00%
Packaging
100MG
Price
$704.55
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
12686
Product name
1-Nitrosopyrrolidine
Packaging
100mg
Price
$860
Updated
2021/12/16
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N-NITROSOPYRROLIDINE Chemical Properties,Usage,Production

Description

N-Nitrosopyrrolidine (NPYR) is a nitrosamine compound that is used primarily as a research chemical and is not produced commercially. There is the possibility of generating NPYR after frying in dry-cured bacon. The major amine precursors to NPYR in cooked bacon are free proline in the adipose tissue and to a lesser extent, collagenous connective tissues. When proline peptides were heated with nitrite at pH 3.4, small amounts of NPYR were formed from all tested peptides. There are several potential sources of exposure of man to this group of potent carcinogens. Certain foods were thought to be derived from the interaction of nitrite with secondary amines in the food, either spontaneously or by the agency of bacteria. Recently the possibility that nitrosamines may be formed from secondary amines and nitrite in the gastrointestinal tract has been explored. The acid conditions that prevail in the human stomach favor the nitrosation of dimethylamine. In addition, at neutral pH, many secondary amines can be nitrosated by nitrite or nitrate in the presence of intestinal bacteria, or the cecal contents of the rat, and soluble enzymes which catalyze the N-nitrosation of several secondary amines have been extracted from two microorganisms. The rate of nitrosamine formation depends greatly on the basicity of the amine; the less basic amines such as diphenylamine and pyrrolidine are nitrosated far more readily than the strongly basic dimethylamine and diethylamine.

Chemical Properties

Light-Yellow Oil

Chemical Properties

N-Nitrosopyrrolidine is a yellow liquid.

Uses

One of the N-nitroso compounds (NOCs) implicated in human colon carcinogenesis, but the toxicological mechanisms involved have not been elucidated.

Uses

1-Nitrosopyrrolidine is one of the N-nitroso compounds (NOCs) implicated in human colon carcinogenesis (1,2,3) but the toxicological mechanisms involved have not been elucidated. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Definition

ChEBI: N-Nitrosopyrrolidine is a member of pyrrolidines.

General Description

Yellow liquid found in certain food products and tobacco smoke. Probably a carcinogen.

Air & Water Reactions

Soluble in water.

Reactivity Profile

A cyclic nitrosamine. Nitrated organics, such as N-NITROSOPYRROLIDINE, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.

Health Hazard

ACUTE/CHRONIC HAZARDS: Flammable.

Fire Hazard

Combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Potential Exposure

N-Nitrosopyrrolidine is a cyclic nitrosamine and a research chemical. Not commercially produced in the U.S.

Carcinogenicity

N-Nitrosopyrrolidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

It is a yellow liquid at room temperature. It is totally soluble in water with solubility of 1.00×10+6 mg l-1 and also is soluble in organic liquids and lipids. Log Pow is -0.19 that expected to move readily from water to soil, sediment, or biota. According to Henry’s law constant 4.89×10-8 atmm3 mol-1 and vapor pressure 0.06 mmHg in 20 ℃, volatilization from water and solid surface is expected to be rapid and an important fate process.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Toxicity evaluation

2-OHTHF and several other reactive electrophilic intermediates can bind with proteins and form DNA adducts mainly with guanines.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste Disposal

Under 40 CFR 261.5 small quantity generators of this waste may qualify for partial exclusion from hazardous waste regulations. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

N-NITROSOPYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-NITROSOPYRROLIDINE Suppliers

Jiaozuo Vaughan Biotechnology Co., Ltd.
Tel
0391-3702345 18739121806
Email
sales@wnbiopharm.com
Country
China
ProdList
968
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58
guoyungurui
Tel
18162595016; 18162595016
Email
3287908757@qq.com
Country
China
ProdList
10336
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
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Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
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930-55-2, N-NITROSOPYRROLIDINERelated Search:


  • 1-nitroso-pyrrolidin
  • 1-Pyrrolidinamine, N-nitroso-
  • Nitrosopyrrolidine
  • N-NITROSOPYRROLIDINE ISOPAC
  • Pyrrolidine, 1-nitroso-
  • N-Nitrosopyrolidine
  • 1-Nitrosopyrrolidine,N-Nitrosopyrrolidine, NPYR
  • NSC 18797
  • Neuropeptide Y receptor type 1
  • NPY1R
  • NPY1-R
  • NPYY1
  • 1-Nitrosopyrrolidine(NPYR)
  • n-nitroso-1-pyrrolidinamin
  • N-Nitrosopyrrolidin
  • n-nitrosopyrrolidin[german]
  • n-n-pyr
  • No-Pyr
  • NPYR
  • n-pyr
  • rcrawastenumberu180
  • tetrahydro-n-nitroso-pyrrol
  • N-NITROSOPYRROLIDINE
  • 1-NITROSOPYRROLIDINE
  • N-Nitrosopyrrolidine@5.0 mg/mL in MeOH
  • N-nitrosopyrrolidineSolution,100mg/L,1ml
  • N-Nitrosopyrrolidine@100 μg/mL in Dichloromethane
  • N-nitropyrrolidine
  • N-nitroso-pyrrolidine NPYR3,7
  • N-Nitrosopyrrolidine in dichloromethane
  • 930-55-2
  • Carcinogens
  • Cancer Research
  • BioChemical
  • Mutagenesis Research Chemicals
  • Nitrosamine
  • Nitric Oxide Reagents