N-NITROSOPYRROLIDINE
- Product Name
- N-NITROSOPYRROLIDINE
- CAS No.
- 930-55-2
- Chemical Name
- N-NITROSOPYRROLIDINE
- Synonyms
- NPYR;NPY1R;NPYY1;n-pyr;NPY1-R;No-Pyr;n-n-pyr;NSC 18797;Nitrosopyrrolidine;N-nitropyrrolidine
- CBNumber
- CB8684002
- Molecular Formula
- C4H8N2O
- Formula Weight
- 100.12
- MOL File
- 930-55-2.mol
N-NITROSOPYRROLIDINE Property
- Boiling point:
- 214 °C(lit.)
- Density
- 1.085 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.489(lit.)
- Flash point:
- 182 °F
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate, Methanol (Slightly)
- form
- Oil
- pka
- -3.14±0.20(Predicted)
- color
- Pale Yellow to Yellow
- CAS DataBase Reference
- 930-55-2(CAS DataBase Reference)
- IARC
- 2B (Vol. 17, Sup 7) 1987
- EPA Substance Registry System
- N-Nitrosopyrrolidine (930-55-2)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 40
- RIDADR
- 2810
- WGK Germany
- 3
- RTECS
- UY1575000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 930-55-2(Hazardous Substances Data)
- Toxicity
- LD50 orally in rats: 900 mg/kg (Druckrey)
N-Bromosuccinimide Price
- Product number
- N545950
- Product name
- 1-Nitrosopyrrolidine
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 487129
- Product name
- NPY1R
- Packaging
- 100ul
- Price
- $529
- Updated
- 2021/12/16
- Product number
- orb597102
- Product name
- NPY1R
- Packaging
- 10μg
- Price
- $290.7
- Updated
- 2021/12/16
- Product number
- CHM0006919
- Product name
- 1-NITROSOPYRROLIDINE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $704.55
- Updated
- 2021/12/16
- Product number
- 12686
- Product name
- 1-Nitrosopyrrolidine
- Packaging
- 100mg
- Price
- $860
- Updated
- 2021/12/16
N-NITROSOPYRROLIDINE Chemical Properties,Usage,Production
Description
N-Nitrosopyrrolidine (NPYR) is a nitrosamine compound that is used primarily as a research chemical and is not produced commercially. There is the possibility of generating NPYR after frying in dry-cured bacon. The major amine precursors to NPYR in cooked bacon are free proline in the adipose tissue and to a lesser extent, collagenous connective tissues. When proline peptides were heated with nitrite at pH 3.4, small amounts of NPYR were formed from all tested peptides. There are several potential sources of exposure of man to this group of potent carcinogens. Certain foods were thought to be derived from the interaction of nitrite with secondary amines in the food, either spontaneously or by the agency of bacteria. Recently the possibility that nitrosamines may be formed from secondary amines and nitrite in the gastrointestinal tract has been explored. The acid conditions that prevail in the human stomach favor the nitrosation of dimethylamine. In addition, at neutral pH, many secondary amines can be nitrosated by nitrite or nitrate in the presence of intestinal bacteria, or the cecal contents of the rat, and soluble enzymes which catalyze the N-nitrosation of several secondary amines have been extracted from two microorganisms. The rate of nitrosamine formation depends greatly on the basicity of the amine; the less basic amines such as diphenylamine and pyrrolidine are nitrosated far more readily than the strongly basic dimethylamine and diethylamine.
Chemical Properties
Light-Yellow Oil
Chemical Properties
N-Nitrosopyrrolidine is a yellow liquid.
Uses
One of the N-nitroso compounds (NOCs) implicated in human colon carcinogenesis, but the toxicological mechanisms involved have not been elucidated.
Uses
1-Nitrosopyrrolidine is one of the N-nitroso compounds (NOCs) implicated in human colon carcinogenesis (1,2,3) but the toxicological mechanisms involved have not been elucidated. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Definition
ChEBI: N-Nitrosopyrrolidine is a member of pyrrolidines.
General Description
Yellow liquid found in certain food products and tobacco smoke. Probably a carcinogen.
Air & Water Reactions
Soluble in water.
Reactivity Profile
A cyclic nitrosamine. Nitrated organics, such as N-NITROSOPYRROLIDINE, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.
Health Hazard
ACUTE/CHRONIC HAZARDS: Flammable.
Fire Hazard
Combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
Potential Exposure
N-Nitrosopyrrolidine is a cyclic nitrosamine and a research chemical. Not commercially produced in the U.S.
Carcinogenicity
N-Nitrosopyrrolidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
It is a yellow liquid at room temperature. It is totally soluble in water with solubility of 1.00×10+6 mg l-1 and also is soluble in organic liquids and lipids. Log Pow is -0.19 that expected to move readily from water to soil, sediment, or biota. According to Henry’s law constant 4.89×10-8 atmm3 mol-1 and vapor pressure 0.06 mmHg in 20 ℃, volatilization from water and solid surface is expected to be rapid and an important fate process.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required
Toxicity evaluation
2-OHTHF and several other reactive electrophilic intermediates can bind with proteins and form DNA adducts mainly with guanines.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
Under 40 CFR 261.5 small quantity generators of this waste may qualify for partial exclusion from hazardous waste regulations. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
N-NITROSOPYRROLIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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