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Lufenuron

Product Name
Lufenuron
CAS No.
103055-07-8
Chemical Name
Lufenuron
Synonyms
fluphenacur;Lufenuron 97%;Lufenuron@1000 μg/mL in Acetone;N-((2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)carbaMoyl)-2,6-difluorobenzaMide;LUFENURON;Lufenurin;cga-184,699;Lufenuron CRS;Lice mite urea;LufenuronStandard
CBNumber
CB6229074
Molecular Formula
C17H8Cl2F8N2O3
Formula Weight
511.15
MOL File
103055-07-8.mol
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Lufenuron Property

Melting point:
174.1°
Density 
1.631±0.06 g/cm3(Predicted)
vapor pressure 
<0.4 x10 -3 Pa (25 °C)
Flash point:
170 °C
storage temp. 
0-6°C
solubility 
100mg/L in organic solvents at 20 ℃
Water Solubility 
<0.06 mg l-1(25 °C)
form 
Solid
pka
8.49±0.46(Predicted)
color 
Off-white to light yellow
JECFA Number
85
BRN 
8398291
InChIKey
PWPJGUXAGUPAHP-UHFFFAOYSA-N
LogP
5.12 at 25℃
CAS DataBase Reference
103055-07-8(CAS DataBase Reference)
EPA Substance Registry System
Benzamide, N-[[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino]carbonyl]-2,6-difluoro- (103055-07-8)
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Safety

Hazard Codes 
Xi;N,N,Xi
Risk Statements 
43-50/53
Safety Statements 
2-24-37-60-61
RIDADR 
3077
WGK Germany 
2
HazardClass 
9
PackingGroup 
III
HS Code 
29242990
Toxicity
LD50 in rats (mg/kg): >2000 orally; LC50 in rats (mg/m3): >2350 (Buholzer)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
31662
Product name
Lufenuron
Purity
PESTANAL
Packaging
100mg
Price
$103
Updated
2024/03/01
Sigma-Aldrich
Product number
1370779
Product name
Lufenuron
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001284
Product name
Lufenuron
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001284
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001261
Product name
Lufenuron for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001261
Price
$220
Updated
2024/03/01
TRC
Product number
L473750
Product name
Lufenuron
Packaging
1g
Price
$460
Updated
2021/12/16
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Lufenuron Chemical Properties,Usage,Production

Description

Lufenuron is an insect development inhibitor of the benzoylphenyl urea class. It demonstrates activity against fleas that have fed on treated cats and dogs and become exposed to lufenuron in the host’s blood. Lufenuron also has activity by virtue of its presence in adult flea feces, leading to its ingestion by flea larvae. Both activities result in the production of eggs that are unable to hatch, causing significant reductions in flea larvae populations. The lipophilicity of lufenuron leads to its deposition in adipose tissues of animals from where it is slowly released into the bloodstream. This permits effective blood concentrations to be maintained throughout the recommended oral dosing interval of 1 month.

Uses

Lufenuron is used for the control of Lepidoptera and Coleoptera larvae on cotton, maize and vegetables, and of citrus whitefly and rust mites on citrus fruit. It is also used to control fleas on pets and cockroaches in houses.

Definition

ChEBI: Lufenuron is a benzoylurea insecticide, a dichlorobenzene, a N-acylurea, an aromatic ether and an organofluorine compound.

Flammability and Explosibility

Not classified

Pharmacology

Antiparasitic. Lufenuron is a benzoylurea insecticide. This class of insecticides was previously used on fruits to decrease damage by insects. Lufenuron (Program) has been used for prevention of flea infections in dogs and cats because it inhibits chitin synthesis. For this use, it has been given to dogs at a dose of 10 mg/kg every 30 days and to cats at a dose of 30 mg/kg every 30 days. It may also have some inhibition on fungal cell membranes because it inhibits the cell wall of fungi, which contain chitin, and other complex polysaccharides. Because of this property on fungal cell membranes, there has been interest in using lufenuron to treat dermatophytes in small animals. However, proven efficacy has been controversial. Well-controlled studies have not confirmed consistent efficacy for treating dermatophytes in animals.

Veterinary Drugs and Treatments

Lufenuron is approved for use in dogs and cats 6 weeks of age and older for the control of flea populations. The combination product of lufenuron and milbemycin (Sentinel?) is indicated for use in puppies and dogs 4 weeks and older for prevention and control flea populations, prevention of heartworm disease, control of adult hookworms, and the removal and control of adult roundworms and whipworms.
Lufeneron showed initial promise as a treatment for fungal infections, but the early enthusiasm has dampened considerably as efficacy appears doubtful.

Metabolic pathway

Only limited information is available in the open literature on the metabolism of lufenuron.

Degradation

Lufenuron is less stable at alkaline pH than under acidic conditions. The DT50 at 25 °C is 160 days at pH 5,70 days at pH 7 and 32 days at pH 9 (PM).

Mode of action

Lufenuron has no systemic or translaminar effect. It is persistent with a transovarial effect. It may reduce the egg-Iaying rate or hinder the hatching process of embryos.

Lufenuron Preparation Products And Raw materials

Raw materials

Preparation Products

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Lufenuron Suppliers

Bailing Agrochemical Co., Ltd.
Tel
0510-86822183
Fax
0086-510-86823825
Email
info@bailingcn.com
Country
China
ProdList
6
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2876
Advantage
58
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from Lufenuron manufacturers

Hubei Lidu New Material Technology Co., Ltd
Product
LUFENURON 103055-07-8
Price
US $0.00/kg
Min. Order
1kg
Purity
0.97
Supply Ability
20tons
Release date
2024-10-30
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Lufenuron 103055-07-8
Price
US $100.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-04-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Lufenuron 103055-07-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
97.2%
Supply Ability
10mt
Release date
2024-07-30

103055-07-8, LufenuronRelated Search:


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  • PROGRAM
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