1-(3-BROMO-4-METHOXYPHENYL)ETHANONE
- Product Name
- 1-(3-BROMO-4-METHOXYPHENYL)ETHANONE
- CAS No.
- 35310-75-9
- Chemical Name
- 1-(3-BROMO-4-METHOXYPHENYL)ETHANONE
- Synonyms
- 4-Acetyl-2-bromoanisole;3'-BROMO-4'-METHOXYACETOPHENONE;1-(3-BROMO-4-METHOXYPHENYL)ETHANONE;Ethanone, 1-(3-bromo-4-methoxyphenyl)-
- CBNumber
- CB6230281
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 35310-75-9.mol
1-(3-BROMO-4-METHOXYPHENYL)ETHANONE Property
- Melting point:
- 84-86°C
- Density
- 1.421
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- color
- Beige
- CAS DataBase Reference
- 35310-75-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B696813
- Product name
- 1-(3-Bromo-4-methoxyphenyl)ethanone
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 2617-9-11
- Product name
- 3'-Bromo-4'-methoxyacetophenone
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- AK-24248
- Product name
- 1-(3-Bromo-4-methoxyphenyl)ethanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $8
- Updated
- 2021/12/16
- Product number
- 126539
- Product name
- 1-(3-Bromo-4-methoxyphenyl)ethanone
- Purity
- >95%
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
- Product number
- 126539
- Product name
- 1-(3-Bromo-4-methoxyphenyl)ethanone
- Purity
- >95%
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
1-(3-BROMO-4-METHOXYPHENYL)ETHANONE Chemical Properties,Usage,Production
Preparation
Obtained by reaction of acetic anhydride with o-bromoanisole in the presence of lithium perchlorate at 100° for 5 h (99%).
Synthesis
100-06-1
35310-75-9
General procedure for the synthesis of 1-(3-bromo-4-methoxyphenyl)ethanone from p-methoxyacetophenone: ketone 7a (5.0 g, 33.3 mmol) and N-bromosuccinimide (NBS, 5.9 g, 33.3 mmol) were dissolved in 100 mL of water and heated to 60 °C. Subsequently, 40% H2SO4 (66.7 mmol, 8.9 mL) was added slowly and dropwise. The reaction mixture was stirred continuously for 5 hours. After completion of the reaction, the mixture was cooled to room temperature and separated by extraction with ethyl acetate (60 mL x 3). The organic phases were combined, washed with saturated NaHCO3 solution, dried over anhydrous MgSO4 and concentrated under reduced pressure to give the crude product 7b (7.5 g, 98% yield) as a white solid. Thin layer chromatography (TLC) Rf value was 0.85 (petroleum ether/ethyl acetate, 3:1).1H NMR (400 MHz, DMSO-d6) δ: 3.09 (3H, s), 3.93 (3H, s), 3.95 (6H, s), 7.92 (1H, d, J = 8.9 Hz), 7.97 (1H, dd, J = 2.1 Hz, 8.9 Hz), 8.10 (2H, d, J = 2.1 Hz); LC-MS m/z: 230.9 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 17, p. 4372 - 4376
[2] Tetrahedron, 2017, vol. 73, # 50, p. 7105 - 7114
[3] Synthetic Communications, 2014, vol. 44, # 2, p. 181 - 187
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3618 - 3628
[5] Organic Letters, 2013, vol. 15, # 9, p. 2108 - 2111
1-(3-BROMO-4-METHOXYPHENYL)ETHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(3-BROMO-4-METHOXYPHENYL)ETHANONE manufacturers
- Product
- 1-(3-BROMO-4-METHOXYPHENYL)ETHANONE 35310-75-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-16
- Product
- 1-(3-BROMO-4-METHOXYPHENYL)ETHANONE 35310-75-9
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-09