1-Boc-pyrrolidine-3-carboxylic acid
- Product Name
- 1-Boc-pyrrolidine-3-carboxylic acid
- CAS No.
- 59378-75-5
- Chemical Name
- 1-Boc-pyrrolidine-3-carboxylic acid
- Synonyms
- 1-(TERT-BUTOXYCARBONYL)PYRROLIDINE-3-CARBOXYLIC ACID;1-N-BOC-BELTA-PROLINE;1-N-BOC-BETA-PROLINE;Daclatasvir Impurity-P;3-CARBOXY-1-BOC-PYRROLIDINE;1-Boc-pyrrolidine-3-carbo...;Benzyl-1-piperazine carbonate;N-Boc-pyrrolidine-3-carboxylate;1-Boc-pyrrolidine-3-carboxylicaci;1-Boc- pyrrolidine -3- formic acid
- CBNumber
- CB6238560
- Molecular Formula
- C10H17NO4
- Formula Weight
- 215.25
- MOL File
- 59378-75-5.mol
1-Boc-pyrrolidine-3-carboxylic acid Property
- Melting point:
- 133-138 °C
- Boiling point:
- 337.2±35.0 °C(Predicted)
- Density
- 1.201±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- soluble in Chloroform
- form
- powder to crystal
- pka
- 4.47±0.20(Predicted)
- color
- White to Light yellow to Light orange
- optical activity
- 0.033°(C=0.01g/ml CHCL3)
- InChI
- InChI=1S/C10H17NO4/c1-10(2,3)15-9(14)11-5-4-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)
- InChIKey
- HRMRQBJUFWFQLX-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(C(O)=O)C1
- CAS DataBase Reference
- 59378-75-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-50/53-41
- Safety Statements
- 26-36/37/39-61-60-39
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 3
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 706590
- Product name
- N-Boc-pyrrolidine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $62
- Updated
- 2023/06/20
- Product number
- B3880
- Product name
- 1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic Acid
- Purity
- >95.0%(GC)(T)
- Packaging
- 1g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- P998020
- Product name
- Pyrrolidine-1,3-dicarboxylicAcid1-tert-ButylEster
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 261765
- Product name
- N-Boc-pyrrolidine-3-carboxylic acid
- Packaging
- 1g
- Price
- $333
- Updated
- 2021/12/16
- Product number
- 4H58-1-U0
- Product name
- Pyrrolidine-3-carboxylic acid, N-Boc protected
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
1-Boc-pyrrolidine-3-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Gray white solid
Uses
Pyrrolidine-1,3-dicarboxylic Acid 1-tert-Butyl Ester is a reactant used in the synthesis of potent and highly selective ERK1,2 inhibitors.
Synthesis
122684-33-7
72925-16-7
The general procedure for the synthesis of (R)-1-Boc-3-carboxypyrrolidine from methyl 1-Boc-pyrrolidine-3-carboxylate was as follows: sodium hydroxide (0.80 g, 20.00 mmol) was dissolved in water (15 mL), and this solution was added to a methanol (30 mL) of methyl 1-Boc-pyrrolidine-3-carboxylate (2.30 g, 10.00 mmol) solution. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, methanol was removed by concentration under reduced pressure. Subsequently, the pH of the solution was adjusted to 4 with 2 M glacial acetic acid and then extracted with dichloromethane (50 mL x 3). The organic layers were combined and dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 1.80 g of oily product in 83.00% yield.
References
[1] Organic Letters, 2005, vol. 7, # 15, p. 3287 - 3289
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
[3] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[4] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0453; 0454; 0455
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059
1-Boc-pyrrolidine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Boc-pyrrolidine-3-carboxylic acid manufacturers
- Product
- 1-Boc-pyrrolidine-3-carboxylic acid 59378-75-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-08
- Product
- 1-Boc-pyrrolidine-3-carboxylic acid 59378-75-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 1-Boc-pyrrolidine-3-carboxylic acid 59378-75-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-31