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Harpagoside

Product Name
Harpagoside
CAS No.
19210-12-9
Chemical Name
Harpagoside
Synonyms
side;Harpa;Harpagosid;Harpogoside;HARPAGOSIDE;HARPAGOSIDE(P);Harpagoside-RM;Harpagoside CRS;HARPAGOSIDE hplc;Einecs 242-881-6
CBNumber
CB6240259
Molecular Formula
C24H30O11
Formula Weight
494.49
MOL File
19210-12-9.mol
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Harpagoside Property

Melting point:
120°C (dec.)
Boiling point:
720.7±60.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
11.70±0.70(Predicted)
form 
Solid
color 
White to Light Yellow
optical activity
[α]/D -50 to -30°
Stability:
Hygroscopic
InChIKey
KVRQGMOSZKPBNS-FMHLWDFHSA-N
SMILES
O[C@@]12C=CO[C@@H](O[C@@]3([H])[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@]1([H])[C@@](C)(OC(=O)/C=C/C1C=CC=CC=1)C[C@H]2O |&1:1,5,7,9,10,12,14,19,21,35,r|
LogP
-1.591 (est)
CAS DataBase Reference
19210-12-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-45-24/25
RIDADR 
3172
WGK Germany 
3
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000673
Product name
Harpagoside
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
1 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
68527
Product name
Harpagoside
Purity
analytical standard
Packaging
10mg
Price
$171
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0000673
Product name
Harpagoside
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000673
Price
$153
Updated
2024/03/01
TCI Chemical
Product number
H1849
Product name
Harpagoside
Packaging
100MG
Price
$336
Updated
2025/07/31
Usbiological
Product number
293662
Product name
Harpagoside
Packaging
5mg
Price
$337
Updated
2021/12/16
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Harpagoside Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, easily soluble in methanol and water, derived from Scrophularia ningpoensis and Uncaria rhynchophylla.

Uses

Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins.

Definition

ChEBI: Harpagoside is a terpene glycoside.

Biological Activity

Harpagoside is an orally available iridoid glycoside and an active component of Harpagophytum extract with cardioprotective effects. Harpagoside is shown to directly bind to and activate ACE2. Allosterically inhibits ACE2 binding to spike protein and reduces viral entry and lessen SARS-CoV-2 infection. Harpagoside was reported to suppress AP-1, IL-6, COX-1/2, c-FOS, NF-ĸB expression and upregulate BMP2 and Wnt signaling pathways.

in vivo

Harpagoside (5 mg/kg; 15 mg/kg; po; once daily for 60 days) has potential neuroprotective effects against Aβ intoxication in an Aβ1-40-induced rat Alzheimer's disease (AD) model[3].

IC 50

COX-1; COX-2

Harpagoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Harpagoside Suppliers

China 292 France 3 Germany 4 India 4 Switzerland 2 United Kingdom 8 United States 24 USA 1 Global 338
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3988
Advantage
66
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
18108052721
Email
2850505130@qq.com
Country
China
ProdList
5167
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Aktin Chemicals, Inc.
Tel
86-28-85159085
Fax
86-28-85152372
Email
info@aktinchem.com
Country
China
ProdList
297
Advantage
62
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
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View Lastest Price from Harpagoside manufacturers

Shaanxi Xianhe Biotech Co., Ltd
Product
Harpagoside 19210-12-9
Price
US $0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
1000KG
Release date
2025-04-29
Sinoway Industrial co., ltd.
Product
Harpagoside 19210-12-9
Price
US $0.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
1.5%-20% UV
Supply Ability
20 tons
Release date
2024-06-27
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Harpagoside 19210-12-9
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-12-11

19210-12-9, HarpagosideRelated Search:

Methyl acrylate Methylparaben Bensulfuron methyl Methyl acetate METSULFURON METHYL Kresoxim-methyl Thiophanate-methyl Methyl Harpagide Parathion-methyl Methyl bromide 8-P-COUMAROYL-HARPAGIDE HARPAGOSIDE(RG) Harpagoside 7-epiphlomiol Devil’s Claw, 1.8-2.2% Harpagoside, Powder DEVILCLAW,1.8-2.2%HARPAGOSIDE,POWDER HARPAGOSIDE(REAGENT / STANDARD GRADE)

  • HARPAGOSIDE
  • Harpagosid
  • [1S-[1alpha,4aalpha,5alpha,7alpha(E),7aalpha]]-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[(allyl-1-oxo-3-phenyl)oxy]cyclopenta[c]pyran-1-yl-beta-D-glucopyranoside
  • [(1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate
  • HARPAGOSIDE WITH HPLC
  • 7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl
  • β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6
  • 8-O-E CINNAMOYL HARPAGIDE
  • 8'-CINNAMOYLHARPAGIDE
  • Harpogoside
  • HARPAGOSIDE hplc
  • [(1S)-1,4a,5,6,7,7aα-Hexahydro-4aα,5α-dihydroxy-7-methyl-7α-[[(E)-1-oxo-3-phenyl-2-propenyl]oxy]cyclopenta[c]pyran-1α-yl]β-D-glucopyranoside
  • (1S-(1alpha,4Aalpha,5alpha,7alpha(E),7aalpha))-1,4A,5,6,7,7A-hexahydro-4A,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(C)pyran-1-yl-beta-D-glucopyranoside
  • Einecs 242-881-6
  • HARPAGOSIDE(P)
  • Harpagoside ,98%
  • Devil s Claw,grapple plant,wood spider
  • Harpa
  • side
  • Harpagoside, 98%, from Harpagophytum procumbens D.C.
  • Harpagoside CRS
  • β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl
  • (1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl cinnamate
  • HARPAGOSIDE(RG) 100mg
  • HARPAGOSIDE(RG) 25mg
  • Harpagoside-RM
  • 19210-12-9
  • C24H30O11
  • 4945
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • reference substance
  • Nitric Oxide
  • Iridoids
  • HA -HTChemical Class
  • Herbal Drugs
  • Natural Compounds
  • Alphabetic
  • H
  • 19210-12-9