ChemicalBook > CAS DataBase List > Harpagoside

Harpagoside

Product Name: Harpagoside
CAS No.: 19210-12-9
Chemical Name: Harpagoside
Synonyms: side;Harpa;Harpagosid;Harpogoside;HARPAGOSIDE;HARPAGOSIDE(P);Harpagoside-RM;Harpagoside CRS;HARPAGOSIDE hplc;Einecs 242-881-6
CBNumber: CB6240259
Molecular Formula: C24H30O11
Formula Weight: 494.49
MOL File: 19210-12-9.mol

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Harpagoside Property

Melting point:: 120°C (dec.)
Boiling point:: 720.7±60.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 11.70±0.70(Predicted)
form: Solid
color: White to Light Yellow
optical activity: [α]/D -50 to -30°
Stability:: Hygroscopic
InChIKey: KVRQGMOSZKPBNS-FMHLWDFHSA-N
SMILES: O[C@@]12C=CO[C@@H](O[C@@]3([H])[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@]1([H])[C@@](C)(OC(=O)/C=C/C1C=CC=CC=1)C[C@H]2O |&1:1,5,7,9,10,12,14,19,21,35,r|
LogP: -1.591 (est)
CAS DataBase Reference: 19210-12-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-45-24/25
RIDADR: 3172
WGK Germany: 3
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000673
Product name: Harpagoside
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 1 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 68527
Product name: Harpagoside
Purity: analytical standard
Packaging: 10mg
Price: $171
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000673
Product name: Harpagoside
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000673
Price: $153
Updated: 2024/03/01

TCI Chemical

Product number: H1849
Product name: Harpagoside
Packaging: 100MG
Price: $336
Updated: 2025/07/31

Usbiological

Product number: 293662
Product name: Harpagoside
Packaging: 5mg
Price: $337
Updated: 2021/12/16

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Harpagoside Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, easily soluble in methanol and water, derived from Scrophularia ningpoensis and Uncaria rhynchophylla.

Uses

Harpagoside is an iridoid glycoside along with with Harpagide (H105270), the potential to be strong anti-inflammatory agents providing the bulk of the observed effects from their plant origins.

Definition

ChEBI: Harpagoside is a terpene glycoside.

Biological Activity

Harpagoside is an orally available iridoid glycoside and an active component of Harpagophytum extract with cardioprotective effects. Harpagoside is shown to directly bind to and activate ACE2. Allosterically inhibits ACE2 binding to spike protein and reduces viral entry and lessen SARS-CoV-2 infection. Harpagoside was reported to suppress AP-1, IL-6, COX-1/2, c-FOS, NF-ĸB expression and upregulate BMP2 and Wnt signaling pathways.

in vivo

Harpagoside (5 mg/kg; 15 mg/kg; po; once daily for 60 days) has potential neuroprotective effects against Aβ intoxication in an Aβ_1-40-induced rat Alzheimer's disease (AD) model^[3].

IC 50

COX-1; COX-2

Harpagoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Harpagoside Suppliers

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View Lastest Price from Harpagoside manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Harpagoside 19210-12-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 1000KG
Release date: 2025-04-29

Sinoway Industrial co., ltd.

Product: Harpagoside 19210-12-9
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 1.5%-20% UV
Supply Ability: 20 tons
Release date: 2024-06-27

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Harpagoside 19210-12-9
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-11

19210-12-9, HarpagosideRelated Search:

Methyl acrylate Methylparaben Bensulfuron methyl Methyl acetate METSULFURON METHYL Kresoxim-methyl Thiophanate-methyl Methyl Harpagide Parathion-methyl Methyl bromide 8-P-COUMAROYL-HARPAGIDE HARPAGOSIDE(RG) Harpagoside 7-epiphlomiol Devil’s Claw, 1.8-2.2% Harpagoside, Powder DEVILCLAW,1.8-2.2%HARPAGOSIDE,POWDER HARPAGOSIDE(REAGENT / STANDARD GRADE)

HARPAGOSIDE

Harpagosid

[1S-[1alpha,4aalpha,5alpha,7alpha(E),7aalpha]]-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[(allyl-1-oxo-3-phenyl)oxy]cyclopenta[c]pyran-1-yl-beta-D-glucopyranoside

[(1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate

HARPAGOSIDE WITH HPLC

7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl

β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6

8-O-E CINNAMOYL HARPAGIDE

8'-CINNAMOYLHARPAGIDE

Harpogoside

HARPAGOSIDE hplc

[(1S)-1,4a,5,6,7,7aα-Hexahydro-4aα,5α-dihydroxy-7-methyl-7α-[[(E)-1-oxo-3-phenyl-2-propenyl]oxy]cyclopenta[c]pyran-1α-yl]β-D-glucopyranoside

(1S-(1alpha,4Aalpha,5alpha,7alpha(E),7aalpha))-1,4A,5,6,7,7A-hexahydro-4A,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(C)pyran-1-yl-beta-D-glucopyranoside

Einecs 242-881-6

HARPAGOSIDE(P)

Harpagoside ,98%

Devil s Claw,grapple plant,wood spider

Harpa

side

Harpagoside, 98%, from Harpagophytum procumbens D.C.

Harpagoside CRS

β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl

(1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl cinnamate

HARPAGOSIDE(RG) 100mg

HARPAGOSIDE(RG) 25mg

Harpagoside-RM

19210-12-9

C24H30O11

4945

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

reference substance

Nitric Oxide

Iridoids

HA -HTChemical Class

Herbal Drugs

Natural Compounds

Alphabetic

19210-12-9