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EPTAPIRONE

Product Name
EPTAPIRONE
CAS No.
179756-58-2
Chemical Name
EPTAPIRONE
Synonyms
F 11440;EPTAPIRONE;F-11440;F11440;Eptapirone(F11440);4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione;4-methyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-1,2,4-triazine-3,5(2H,4H)-dione;1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-;Serotonin Receptor,5-HT Receptor,Eptapirone,inhibit,F-11440,5-hydroxytryptamine Receptor,Inhibitor,F11440
CBNumber
CB62448965
Molecular Formula
C16H23N7O2
Formula Weight
345.4
MOL File
179756-58-2.mol
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EPTAPIRONE Property

Boiling point:
517.4±60.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMF:10.0(Max Conc. mg/mL);28.95(Max Conc. mM)
form 
A crystalline solid
pka
7.72±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23449
Product name
Eptapirone
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
23449
Product name
Eptapirone
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
23449
Product name
Eptapirone
Purity
≥98%
Packaging
10mg
Price
$301
Updated
2024/03/01
Cayman Chemical
Product number
23449
Product name
Eptapirone
Purity
≥98%
Packaging
25mg
Price
$618
Updated
2024/03/01
TRC
Product number
E591305
Product name
Eptapirone
Packaging
10mg
Price
$175
Updated
2021/12/16
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EPTAPIRONE Chemical Properties,Usage,Production

Description

Eptapirone is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 4.8 nM in a radioligand binding assay). It is selective for 5-HT1A over other 5-HT receptor subtypes, dopamine D2 receptors, α1-adrenergic receptors, and histamine H1 receptors (Kis = <10,000, 1,770, 691.8, and <10,000 nM, respectively). Eptapirone inhibits cAMP stimulation induced by forskolin in HA7 cells transfected with human 5-HT1A receptors (EC50 = 158 nM). In vivo, eptapirone increases extracellular 5-HT in the ventral hippocampus of rats (ED50 = 0.049 mg/kg) and serum corticosterone levels when administered p.o. or i.p. (ED50s = 0.16 and 0.057 mg/kg, respectively). It decreases immobility in rats in a forced swim test and increases punished responding in a pigeon conflict procedure, demonstrating antidepressant-like and anxiolytic activity. Eptapirone (2.5 mg/kg, p.o.) also attenuates hypertension and tachycardia induced by sibutramine in rats with no effect on sibutramine-induced hypophagia.

Uses

Eptapirone is 5-HT1A receptor agonist with anxiolytic and antidepressant potential.

Definition

ChEBI: Eptapirone is a N-arylpiperazine.

EPTAPIRONE Preparation Products And Raw materials

Raw materials

Preparation Products

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EPTAPIRONE Suppliers

China 52 India 1 United States 7 Global 60
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
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View Lastest Price from EPTAPIRONE manufacturers

Career Henan Chemical Co
Product
EPTAPIRONE 179756-58-2
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

179756-58-2, EPTAPIRONERelated Search:

EPTAPIRONE

  • EPTAPIRONE
  • 4-methyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-1,2,4-triazine-3,5(2H,4H)-dione
  • F 11440
  • 4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione
  • F-11440;F11440
  • 1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-
  • Eptapirone(F11440)
  • Serotonin Receptor,5-HT Receptor,Eptapirone,inhibit,F-11440,5-hydroxytryptamine Receptor,Inhibitor,F11440
  • 179756-58-2