7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Product Name: 7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 179943-57-8
Chemical Name: 7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
Synonyms: 7-bromo-4-hydroxyquinoline-3-carboxylate;Ethyl7-BroMo-4-hydroxy-3-quinolinecarboxylate;Ethyl 4-hydroxy-7-broMoquinoline-3-carboxylate;Ethyl 7-bromo-4-hydroxyquinoline-3-carboxylate;3-Quinolinecarboxylicacid, 7-bromo-4-hydroxy-, ethy..;3-Quinolinecarboxylic acid, 7-bromo-4-hydroxy-, ethyl ester;ethyl 7-bromo-1,4-dihydro-4-oxo-3-quinolinecarboxylate, 95%;7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
CBNumber: CB62450003
Molecular Formula: C12H10BrNO3
Formula Weight: 296.12
MOL File: 179943-57-8.mol

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7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:: 307-309 °C
Boiling point:: 385.5±37.0 °C(Predicted)
Density: 1.593±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 2.16±0.50(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E900733
Product name: Ethyl7-bromo-4-hydroxyquinoline-3-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E900733
Product name: Ethyl7-bromo-4-hydroxyquinoline-3-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: W3907
Product name: Ethyl7-bromo-4-hydroxyquinoline-3-carboxylate
Packaging: 1g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: W3907
Product name: Ethyl7-bromo-4-hydroxyquinoline-3-carboxylate
Packaging: 5g
Price: $309
Updated: 2021/12/16

Matrix Scientific

Product number: 073257
Product name: Ethyl 7-bromo-4-hydroxyquinoline-3-carboxylate
Purity: 95+%
Packaging: 1g
Price: $416
Updated: 2021/12/16

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7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

351893-47-5

208580-23-8

Dowtherm (50 mL) was added to a 100 mL two-necked round-bottomed flask and heated to 250 °C in a sand bath. Maintaining this temperature, diethyl {[(3-bromophenyl)amino]methylene}malonate (Intermediate 32, 10.0 g, 29.2 mmol) was added to the reaction system and the reaction was continued at 250 °C for 1 hour. After completion of the reaction, the reaction mixture was cooled to room temperature and a white solid was collected by filtration and dried to give ethyl 7-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate 6.0 g in 69.3% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 1.07 (t, 3H), 1.22 (s, 12H), 3.16 (q, 2H), 7.29 (m, 1H), 7.31 (d, 2H), 7.61 (s, 1H), 7.88 (s, 1H), 8.31 (s, 1H), 8.65 (s, 1H), and 9.44 (s, 1H).

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5522 - 5537
[2] Patent: WO2009/147433, 2009, A1. Location in patent: Page/Page column 279
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 15, p. 4790 - 4800
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 4, p. 1010 - 1013
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 15, p. 5055 - 5058

7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Suppliers

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View Lastest Price from 7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER manufacturers

Career Henan Chemical Co

Product: 7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 179943-57-8
Price: US $6.68/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

179943-57-8, 7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTERRelated Search:

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7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Ethyl 7-bromo-4-hydroxyquinoline-3-carboxylate

Ethyl 4-hydroxy-7-broMoquinoline-3-carboxylate

Ethyl7-BroMo-4-hydroxy-3-quinolinecarboxylate

7-bromo-4-hydroxyquinoline-3-carboxylate

3-Quinolinecarboxylic acid, 7-bromo-4-hydroxy-, ethyl ester

3-Quinolinecarboxylicacid, 7-bromo-4-hydroxy-, ethy..

ethyl 7-bromo-1,4-dihydro-4-oxo-3-quinolinecarboxylate, 95%

179943-57-8