ChemicalBook > CAS DataBase List > 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Product Name
4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
CAS No.
26892-90-0
Chemical Name
4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
Synonyms
ETHYL 4-HYDROXYQUINOLINE-3-CARBOXYLATE;Sotuletinib Impurity4;Ivacaftor impurities10;3-Ethoxycarbonyl-4-quinolinol;oline-3-carboxylic acid ethyl ester;ethyl 4-oxo-1H-quinoline-3-carboxylate;Ethyl4-Hydroxyquinoline-3-carboxylate>4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;4-keto-1H-quinoline-3-carboxylic acid ethyl ester;3-Quinolinecarboxylic acid, 4-hydroxy-, ethyl ester
CBNumber
CB4720153
Molecular Formula
C12H11NO3
Formula Weight
217.22
MOL File
26892-90-0.mol
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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:
271°C(lit.)
Boiling point:
334.9±22.0 °C(Predicted)
Density 
1.280±0.06 g/cm3(Predicted)
storage temp. 
Store at room temperature
pka
2.62±0.50(Predicted)
form 
powder to crystal
color 
White to Light yellow to Light orange
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BBO000183
Product name
4-Hydroxyquinoline-3-carboxylic acid ethyl ester
Purity
Aldrich
Packaging
1g
Price
$107
Updated
2025/07/31
TCI Chemical
Product number
E1142
Product name
Ethyl 4-Hydroxyquinoline-3-carboxylate
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$46
Updated
2025/07/31
TCI Chemical
Product number
E1142
Product name
Ethyl 4-Hydroxyquinoline-3-carboxylate
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$159
Updated
2025/07/31
TRC
Product number
H953453
Product name
4-Hydroxyquinoline-3-carboxylic acid ethyl ester
Packaging
1g
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
045036
Product name
Ethyl 4-oxo-1,4-dihydro-3-quinolinecarboxylate
Purity
>95%
Packaging
5g
Price
$74
Updated
2021/12/16
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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

54535-22-7

26892-90-0

General procedure for the synthesis of ethyl 4-hydroxyquinoline-3-carboxylate from diethyl 2-phenylaminomethylidene-malonate: In a 1L three-necked flask fitted with a mechanical stirrer, diethyl 2-phenylaminomethylidene-malonate (26.3 g, 0.100 mol), polyphosphoric acid (270 g), and phosphorochloride (750 g) were added. The reaction mixture was heated to 70 °C and stirred at this temperature for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and then filtered. The filtered residue was treated with aqueous sodium carbonate (Na2CO3), filtered again, washed with water and finally dried. Ethyl 4-hydroxyquinoline-3-carboxylate was obtained as a light brown solid (15.2 g, 70% yield).

References

[1] Patent: US4079058, 1978, A
[2] Patent: US2008/90864, 2008, A1. Location in patent: Page/Page column 7
[3] Patent: WO2007/79139, 2007, A2. Location in patent: Page/Page column 46
[4] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 1 - 16
[5] Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2000, vol. 344, p. 163 - 168

4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER Suppliers

Americas 1 China 94 Europe 1 Germany 2 India 7 Japan 1 Sweden 1 The Netherlands 1 United Kingdom 6 United States 15 Global 129
TCI (Shanghai) Development Co., Ltd.
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View Lastest Price from 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER manufacturers

Career Henan Chemical Co
Product
4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 26892-90-0
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-98%
Supply Ability
200KG
Release date
2019-09-03

26892-90-0, 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTERRelated Search:

6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE Ethyl 7-chloro-4-hydroxy-8-methylquinoline-3-carboxylate 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 8-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 4-HYDROXY-2-QUINOLINECARBOXYLATE 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 7-BROMO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 4-Hydroxyquinoline 4-HYDROXY-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 5,7-DIMETHYL-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 8-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 5,8-DIMETHYL-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 6-BROMO-8-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLATE Ethyl 6,8-difluoro-4-hydroxyquinoline-3-carboxylate 6-CHLORO-4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ETHYL ESTER

  • ETHYL 4-HYDROXYQUINOLINE-3-CARBOXYLATE
  • 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
  • 4-Hydroxyquinoline-3-carboxylic acid ethyl ester 98%
  • 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER, 95+%
  • 4-keto-1H-quinoline-3-carboxylic acid ethyl ester
  • ethyl 4-oxo-1H-quinoline-3-carboxylate
  • 3-Quinolinecarboxylic acid, 4-hydroxy-, ethyl ester
  • 3-Ethoxycarbonyl-4-quinolinol
  • Ethyl4-Hydroxyquinoline-3-carboxylate&gt
  • 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
  • Ivacaftor impurities10
  • 4-Hydroxy-1,2-dihydro-quinoline-3-carboxylic acid ethyl ester
  • Sotuletinib Impurity4
  • oline-3-carboxylic acid ethyl ester
  • 26892-90-0
  • 26829-90-0
  • Acids and Derivatives
  • Heterocycles