ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
- Product Name
- ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
- CAS No.
- 35975-57-6
- Chemical Name
- ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
- Synonyms
- Ux00004205;BUTTPARK 89\01-99;Ethyl 4-hydroxy-8-broMoquinoline-3-carboxylate;ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE;ETHYL 8-BROMO-4-HYDROXY-3-QUINOLINECARBOXYLATE;4-Hydroxy-8-broMoquinoline-3-carboxylic acid ethyl ester;8-Bromo-4-hydroxy-3-quinolinecarboxylic acid ethyl ester;8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;3-Quinolinecarboxylic acid, 8-bromo-4-hydroxy-, ethyl ester;ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber
- CB6718448
- Molecular Formula
- C12H10BrNO3
- Formula Weight
- 296.12
- MOL File
- 35975-57-6.mol
ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE Property
- Boiling point:
- 385.5±37.0 °C(Predicted)
- Density
- 1.593±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 2.16±0.50(Predicted)
- form
- solid
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C12H10BrNO3/c1-2-17-12(16)8-6-14-10-7(11(8)15)4-3-5-9(10)13/h3-6H,2H2,1H3,(H,14,15)
- InChIKey
- XDDQBYKFJZYKPE-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2Br)C(O)=C(C(OCC)=O)C=1
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- BBO000225
- Product name
- 8-Bromo-4-hydroxyquinoline-3-carboxylic acid ethyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $259
- Updated
- 2025/07/31
- Product number
- E900735
- Product name
- Ethyl8-bromo-4-hydroxyquinoline-3-carboxylate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H29-9-X2
- Product name
- Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- HCH0014149
- Product name
- ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $642.99
- Updated
- 2021/12/16
- Product number
- HCH0014149
- Product name
- ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $781.24
- Updated
- 2021/12/16
ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
87-13-8
615-36-1
35975-57-6
The reaction was carried out with 2-bromoaniline (2.5 g, 14.62 mmol) and diethyl ethoxymethylene malonate (3.16 g, 14.62 mmol) by heating at 100 °C for 3 hours. Subsequently, the volatiles in the reaction system were removed by a stream of nitrogen. The resulting melt was slowly added to boiling diphenyl ether (10 mL) and the mixture was heated to reflux for 2 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature and petroleum ether was added to precipitate the product. The precipitated solid was collected by filtration and dried to give ethyl 4-hydroxy-8-bromoquinoline-3-carboxylate (3.5 g). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 11.65 (br s, 1H), 8.45 (s, 1H), 8.17 (d, J = 7.8 Hz, 1H), 8.05 (d, J = 7.8 Hz, 1H), 7.39-7.34 (t, J = 7.8 Hz, 1H), 4.26-4.19 (q, J = 7.2,14.1Hz, 2H), 1.30-1.26 (t, J = 6.9Hz, 3H).
References
[1] Journal of Organic Chemistry, 2017, vol. 82, # 24, p. 13756 - 13767
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 8, p. 1487 - 1490
[3] Patent: US2003/144507, 2003, A1
[4] Patent: EP1258252, 2002, A1
[5] Patent: US2004/18192, 2004, A1
ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE Suppliers
- Tel
- 微信 17321281695 18019252918
- Fax
- 021-31261685
- sale@amkchem.com
- Country
- China
- ProdList
- 9405
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1998
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
View Lastest Price from ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE manufacturers
- Product
- ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE 35975-57-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-20