3-(4-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- Product Name
- 3-(4-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS No.
- 26510-95-2
- Chemical Name
- 3-(4-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- Synonyms
- Ethyl (p-Bromobenzoyl)acetate;ETHYL (4-BROMOBENZOYL)ACETATE;ethyle(4-bromobenzoyl)acetate;Ethyl (4-bromobenzoyl)acetate,95%;Ethyl 4-bromo-β-oxobenzenepropanoate;3-(4-Bromophenyl)-3-oxo-propionic acid;ethyl3-(4-bromophenyl)-3-oxo-propionate;(4-Bromobenzoyl)acetic Acid Ethyl Ester;ETHYL 3-(4-BROMOPHENYL)-3-OXOPROPANOATE;Benzenepropanoic acid,4-bromo-b-oxo-, ethyl ester
- CBNumber
- CB2256766
- Molecular Formula
- C11H11BrO3
- Formula Weight
- 271.11
- MOL File
- 26510-95-2.mol
3-(4-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Property
- Boiling point:
- 268-269 °C(lit.)
- Density
- 1.432 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5700(lit.)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Liquid
- pka
- 9.56±0.25(Predicted)
- color
- Clear yellow
- CAS DataBase Reference
- 26510-95-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 559202
- Product name
- Ethyl (4-bromobenzoyl)acetate
- Purity
- ≥95.0%
- Packaging
- 1g
- Price
- $109
- Updated
- 2023/06/20
- Product number
- 559202
- Product name
- Ethyl (4-bromobenzoyl)acetate
- Purity
- ≥95.0%
- Packaging
- 5g
- Price
- $166
- Updated
- 2023/06/20
- Product number
- E1117
- Product name
- Ethyl (4-Bromobenzoyl)acetate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $164
- Updated
- 2025/07/31
- Product number
- E1117
- Product name
- Ethyl (4-Bromobenzoyl)acetate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $486
- Updated
- 2025/07/31
- Product number
- E900850
- Product name
- Ethyl3-(4-bromophenyl)-3-oxo-propionate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
3-(4-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
Clear yellow to light brown liquid
Uses
Ethyl 3-(4-bromophenyl)-3-oxo-propionate
Uses
Ethyl (4-bromobenzoyl)acetate may be used to synthesize 2-(carboethoxy)-3-(4′-bromo)phenylquinoxaline 1,4-dioxide.
General Description
Ethyl (4-bromobenzoyl)acetate can be prepared by employing the following reagents:
- ethyl acetylacetate
- petroleum ether
- NaOH
- 4-bromobenzoyl chloride
Synthesis
99-90-1
105-58-8
26510-95-2
Diethyl carbonate (295 g, 2.50 mol) was slowly added to a suspension of NaH (80 g, 60% mineral oil dispersion, 2 mol) in toluene (1.2 L) at 0 °C. After stirring at room temperature for 2 h, the mixture was slowly added dropwise under reflux conditions to a solution of p-bromoacetophenone (99 g, 0.50 mol) in toluene (400 mL). After the reaction mixture was refluxed overnight, it was cooled to room temperature and quenched sequentially with acetic acid (140 mL) and 2M aqueous hydrochloric acid (864 mL). The resulting mixture was extracted with ethyl acetate (400 mL x 3), the organic phases were combined, washed sequentially with water (500 mL x 4) and saturated saline (200 mL x 2) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was dried under vacuum to give ethyl (4-bromobenzoyl)acetate (122 g, 90% yield) as an oil.LC-MS (ESI): m/z 271.0 [M + H]+.
References
[1] European Journal of Organic Chemistry, 2017, vol. 2017, # 31, p. 4543 - 4547
[2] Patent: WO2012/58125, 2012, A1. Location in patent: Page/Page column 147
[3] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 1950 - 1956
[4] Archiv der Pharmazie, 2003, vol. 336, # 3, p. 181 - 190
[5] Molecules, 2004, vol. 9, # 3, p. 135 - 157
3-(4-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(4-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER manufacturers
- Product
- 3-(4-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 26510-95-2
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-30