TOMEGLOVIR
- Product Name
- TOMEGLOVIR
- CAS No.
- 233254-24-5
- Chemical Name
- TOMEGLOVIR
- Synonyms
- TOMEGLOVIR;BAY 38-4766;tomeglovir cas;Tomeglovir (BAY-38-4766);N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide;Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-
- CBNumber
- CB62451318
- Molecular Formula
- C23H27N3O4S
- Formula Weight
- 441.54
- MOL File
- 233254-24-5.mol
TOMEGLOVIR Property
- Density
- 1.334±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 108 mg/mL (244.60 mM)
- form
- Solid
- pka
- 8.96±0.50(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-0027853
- Product name
- Tomeglovir
- Purity
- 99.45%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-0027853
- Product name
- Tomeglovir
- Purity
- 99.45%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0027853
- Product name
- Tomeglovir
- Purity
- 99.45%
- Packaging
- 25mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CS-0027853
- Product name
- Tomeglovir
- Purity
- 99.45%
- Packaging
- 50mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- API0019436
- Product name
- TOMEGLOVIR
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.25
- Updated
- 2021/12/16
TOMEGLOVIR Chemical Properties,Usage,Production
Biological Activity
Tomeglovir is an anti-CMV agent that inhibits the progression of viral DNA concatemers with IC50 values of 0.34 μM and 0.039 μM for HCMV and MCMV, respectively.
in vitro
Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC 50 s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC 50 s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC 50 s of 1.03 ± 0.57 μM and < 1 μM.
in vivo
Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, po) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. It (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD 50 is >2000 mg/kg in mice and rats.
target
IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)
TOMEGLOVIR Preparation Products And Raw materials
Raw materials
Preparation Products
TOMEGLOVIR Suppliers
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