TOMEGLOVIR

Product Name: TOMEGLOVIR
CAS No.: 233254-24-5
Chemical Name: TOMEGLOVIR
Synonyms: TOMEGLOVIR;BAY 38-4766;tomeglovir cas;Tomeglovir (BAY-38-4766);N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide;Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-
CBNumber: CB62451318
Molecular Formula: C23H27N3O4S
Formula Weight: 441.54
MOL File: 233254-24-5.mol

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TOMEGLOVIR Property

Density: 1.334±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 108 mg/mL (244.60 mM)
form: Solid
pka: 8.96±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0027853
Product name: Tomeglovir
Purity: 99.45%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0027853
Product name: Tomeglovir
Purity: 99.45%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0027853
Product name: Tomeglovir
Purity: 99.45%
Packaging: 25mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0027853
Product name: Tomeglovir
Purity: 99.45%
Packaging: 50mg
Price: $480
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0019436
Product name: TOMEGLOVIR
Purity: 95.00%
Packaging: 5MG
Price: $500.25
Updated: 2021/12/16

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TOMEGLOVIR Chemical Properties,Usage,Production

Biological Activity

Tomeglovir is an anti-CMV agent that inhibits the progression of viral DNA concatemers with IC50 values of 0.34 μM and 0.039 μM for HCMV and MCMV, respectively.

in vitro

Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC ₅₀ s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC ₅₀ s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC ₅₀ s of 1.03 ± 0.57 μM and < 1 μM.

in vivo

Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, po) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. It (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD ₅₀ is >2000 mg/kg in mice and rats.

target

IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)

TOMEGLOVIR Preparation Products And Raw materials

Raw materials

Preparation Products

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TOMEGLOVIR Suppliers

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TOMEGLOVIR

N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide

BAY 38-4766

Tomeglovir (BAY-38-4766)

Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-

tomeglovir cas

233254-24-5