ChemicalBook > CAS DataBase List > 1-BROMO-3-CHLORO-2-IODOBENZENE

1-BROMO-3-CHLORO-2-IODOBENZENE

Product Name
1-BROMO-3-CHLORO-2-IODOBENZENE
CAS No.
450412-28-9
Chemical Name
1-BROMO-3-CHLORO-2-IODOBENZENE
Synonyms
2-Bromo-6-chloroiodobenzene;1-BROMO-3-CHLORO-2-IODOBENZENE;2-Bromo-6-chloroiodobenzene 99%;1-Bromo-3-chloro-2-Iodobenzenne;Benzene, 1-bromo-3-chloro-2-iodo-;1-Bromo-3-chloro-2-iodobenzene,97%
CBNumber
CB62452476
Molecular Formula
C6H3BrClI
Formula Weight
317.35
MOL File
450412-28-9.mol
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1-BROMO-3-CHLORO-2-IODOBENZENE Property

Melting point:
75-76 °C(Solv: ethanol (64-17-5))
Boiling point:
285.9±20.0 °C(Predicted)
Density 
2.272±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Solid
Appearance
Off-white to light brown Solid
Sensitive 
Light Sensitive
InChI
InChI=1S/C6H3BrClI/c7-4-2-1-3-5(8)6(4)9/h1-3H
InChIKey
GIMVCZMZRZGDTL-UHFFFAOYSA-N
SMILES
C1(Br)=CC=CC(Cl)=C1I
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Safety

HS Code 
2903998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5765
Product name
1-Bromo-3-chloro-2-iodobenzene
Packaging
1G
Price
$45
Updated
2025/07/31
TCI Chemical
Product number
B5765
Product name
1-Bromo-3-chloro-2-iodobenzene
Packaging
5G
Price
$155
Updated
2025/07/31
TRC
Product number
B415633
Product name
1-Bromo-3-chloro-2-iodobenzene
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
1600-W-02
Product name
2-Bromo-6-chloroiodobenzene
Purity
99%
Packaging
5G
Price
$96
Updated
2021/12/16
Apolloscientific
Product number
OR400660
Product name
2-Bromo-6-chloroiodobenzene
Purity
99%
Packaging
1g
Price
$15
Updated
2021/12/16
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1-BROMO-3-CHLORO-2-IODOBENZENE Chemical Properties,Usage,Production

Synthesis

108-37-2

450412-28-9

Step 1. Synthesis of 1-bromo-3-chloro-2-iodobenzene: To an anhydrous THF (664 mL) solution containing diisopropylamine (76 mL, 0.4 mol) was slowly added dropwise a n-hexane (220 mL) solution of 2.5 M n-butyllithium (n-BuLi, 160 mL, 0.4 mol) at -78 °C for 1 h under nitrogen protection. The reaction temperature was maintained at -78 °C and stirring was continued for 1 h. A solution of 1-bromo-3-chlorobenzene (76 g, 0.4 mol) in anhydrous THF (300 mL) was added slowly dropwise. After the dropwise addition, the reaction was kept at -78 °C for 1 h. Subsequently, a solution of anhydrous THF (400 mL) with iodine (101 g, 0.4 mol) was added slowly dropwise. The reaction system was gradually warmed to room temperature over 2 hours and stirring was continued at room temperature for 18 hours. After completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product (120 g). The crude product was purified by distillation under reduced pressure to give 1-bromo-3-chloro-2-iodobenzene (115 g, 91% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and mass spectrometry (MS): 1H NMR δ 7.12-7.18 (t, 1H), 7.35-7.41 (dd, 1H), 7.49-7.54 (dd, 1H); MS (E/Z): 317 (M+H+).

References

[1] Patent: WO2008/124575, 2008, A1. Location in patent: Page/Page column 103
[2] Patent: US2010/317697, 2010, A1. Location in patent: Page/Page column 47
[3] Patent: WO2008/124582, 2008, A1. Location in patent: Page/Page column 86-87
[4] Patent: WO2007/117560, 2007, A2. Location in patent: Page/Page column 169
[5] Patent: WO2008/124577, 2008, A1. Location in patent: Page/Page column 69

1-BROMO-3-CHLORO-2-IODOBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BROMO-3-CHLORO-2-IODOBENZENE Suppliers

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View Lastest Price from 1-BROMO-3-CHLORO-2-IODOBENZENE manufacturers

Career Henan Chemical Co
Product
1-BROMO-3-CHLORO-2-IODOBENZENE 450412-28-9
Price
US $1.00/g
Min. Order
1g
Purity
97%
Supply Ability
100kg
Release date
2020-01-09

450412-28-9, 1-BROMO-3-CHLORO-2-IODOBENZENERelated Search:

1-BROMO-4-CHLOROISOQUINOLINE 1-broMo-5-chloroisoquinoline 1-Bromo-2,3-dimethoxybenzene 1-BROMO-2-CHLORO-3-NITROBENZENE 2-BROMO-6-IODOTOLUENE 1-Bromo-2-fluoro-4-(methylsulfonyl)benzene 1-broMo-8-chloroisoquinoline 1-Bromo-2-iodo-3-methoxybenzene 1-BROMO-3-METHYLIMIDAZO[1,5-A]PYRAZINE 1-BROMO-7-CHLORO-ISOQUINOLINE 1-BroMoisoquinolin-5-aMine 1-BROMO-6-CHLORO-ISOQUINOLINE 3-BROMOCHLOROBENZENE 3-BROMO-5-CHLORO-4-IODOBENZOTRIFLUORIDE 1-BROMO-3,5-DICHLORO-2-IODOBENZENE 1-CHLORO-3,5-DIBROMO-2-IODOBENZENE 2-Bromo-4-fluoro-6-chloroiodobenzene 1-BROMO-3-CHLORO-2-IODOBENZENE

  • 1-Bromo-3-chloro-2-Iodobenzenne
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  • 1-BROMO-3-CHLORO-2-IODOBENZENE
  • Benzene, 1-bromo-3-chloro-2-iodo-
  • 1-Bromo-3-chloro-2-iodobenzene,97%
  • 2-Bromo-6-chloroiodobenzene
  • 450412-28-9