2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINE

Product Name: 2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINE
CAS No.: 25797-03-9
Chemical Name: 2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINE
Synonyms: 2-PHENYL-4-AZAINDOLE;2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINE;1H-Pyrrolo[3,2-b]pyridine, 2-phenyl-
CBNumber: CB62452537
Molecular Formula: C13H10N2
Formula Weight: 194.23
MOL File: 25797-03-9.mol

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2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINE Property

Melting point:: 235-242 °C
Boiling point:: 407.2±25.0 °C(Predicted)
Density: 1.211±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.46±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: P400415
Product name: 2-Phenyl-4-azaindole
Packaging: 50mg
Price: $110
Updated: 2021/12/16

Matrix Scientific

Product number: 072285
Product name: 2-Phenyl-4-azaindole
Purity: 95+%
Packaging: 250mg
Price: $164
Updated: 2021/12/16

Matrix Scientific

Product number: 072285
Product name: 2-Phenyl-4-azaindole
Purity: 95+%
Packaging: 500mg
Price: $252
Updated: 2021/12/16

Matrix Scientific

Product number: 072285
Product name: 2-Phenyl-4-azaindole
Purity: 95+%
Packaging: 1g
Price: $408
Updated: 2021/12/16

AK Scientific

Product number: W4916
Product name: 2-Phenyl-4-azaindole
Packaging: 1g
Price: $600
Updated: 2021/12/16

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2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINE Chemical Properties,Usage,Production

Synthesis

945607-88-5

25797-03-9

General procedure for the synthesis of 2-phenyl-4-azaindole from the compound (CAS: 945607-88-5): Phosphorus trichloride (0.02 mL, density 1.57, 0.22 mmol) was added slowly and dropwise to a solution of pyridine N-oxide (12 mg, 0.038 mmol) in chloroform (1 mL) under stirring conditions. The reaction mixture was heated to 80 °C and maintained at this temperature for 7 hours. Upon completion of the reaction, ice was added to the mixture and the pH was subsequently adjusted to 10 with saturated aqueous sodium bicarbonate solution to neutralize the reaction system. After continued stirring for 30 minutes, extraction was carried out with chloroform (3 x 15 mL). The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography with a gradient elution of 100% ethyl acetate to 10% methanol/ethyl acetate as eluent to afford the target product 2-phenyl-4-azaindole as a white solid (6 mg, 0.03 mmol, 80% yield). The melting point of the product was 250-252 °C. IR spectrum (neat, cm^-1): 3439, 1642. nMR hydrogen spectrum (400 MHz, MeOD) δ 7.23 (1H, s), 6.58 (1H, d, J = 5.7 Hz), 6.29 (2H, d, J = 7.7 Hz), 5.93 (2H, t, J = 7.5 Hz), 5.89 (1H, d, J = 5.9 Hz), 5.82 (1H, t, J = 7.3 Hz), 5.45 (1H, s). NMR carbon spectrum (100 MHz, MeOD) δ 143.5, 142.8, 141.9, 140.5, 133.2, 130.3, 129.5, 127.9, 126.8, 108.1, 99.1. high-resolution mass spectrometry (ESI): C13H10N2 ([M]+) calculated value 194.0844, measured value 194.0852.

References

[1] Journal of Organic Chemistry, 2007, vol. 72, # 14, p. 5152 - 5160
[2] Patent: WO2008/22467, 2008, A1. Location in patent: Page/Page column 138

2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINE Suppliers

China 27 India 1 United States 4 Global 32

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25797-03-9, 2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINERelated Search:

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2-PHENYL-1H-PYRROLO[3,2-B]PYRIDINE

2-PHENYL-4-AZAINDOLE

1H-Pyrrolo[3,2-b]pyridine, 2-phenyl-

25797-03-9

Azaindoles