ESCIN IIB

Product Name: ESCIN IIB
CAS No.: 158800-83-0
Chemical Name: ESCIN IIB
Synonyms: EscinID;ESCIN IIB;AESCIN IIB; 06035642G6;b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-;β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-
CBNumber: CB62454203
Molecular Formula: C54H84O23
Formula Weight: 1101.23
MOL File: 158800-83-0.mol

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ESCIN IIB Property

Boiling point:: 1111.9±65.0 °C(Predicted)
Density: 1.45±0.1 g/cm3 (20 ºC 760 Torr)
pka: 2.63±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: N2138
Product name: AescinIIB
Packaging: 20mg
Price: $200
Updated: 2021/12/16

AvaChem

Product number: 2397
Product name: Escin IIb
Packaging: 5mg
Price: $390
Updated: 2021/12/16

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ESCIN IIB Chemical Properties,Usage,Production

Uses

Escin IIb, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals[1]. Escin IIb showed potent protective effects against ethanol-induced gastric mucosal lesions[2].

in vivo

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibit the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest^[1].
Escin IIb (10-50 mg/kg; p.o.) potently inhibits ethanol-induced gastric mucosal lesions^[2].

Animal Model:	Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)^[2]
Dosage:	P.o.
Administration:	10-50 mg/kg
Result:	Showed a potent protective effect against ethanol-induced gastric lesions in rats.

References

[1] Matsuda H, et al. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull. 1997;20(10):1092-1095. DOI:10.1248/bpb.20.1092
[2] Matsuda H, et al. Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. Eur J Pharmacol. 1999;373(1):63-70. DOI:10.1016/s0014-2999(99)00249-6

ESCIN IIB Preparation Products And Raw materials

Raw materials

Preparation Products

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ESCIN IIB Suppliers

China 65 United States 8 Global 73

AdooQ BioScience, LLC

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Shanghai BeiZhuo Biotech Co., Ltd.

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View Lastest Price from ESCIN IIB manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: AescinIIB 158800-83-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-23

Career Henan Chemical Co

Product: 06035642G6 158800-83-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-25

158800-83-0, ESCIN IIBRelated Search:

NA GYPENOSIDE-XVII Clinodiside D Isoescin IB Escin Ie AESCIN IA(SH) Protoaescigenin (3beta,4beta,16alpha,21beta,22alpha)-28-(Acetyloxy)-16,22,23-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-beta-D-glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranosiduronic acid escin IIa AESCIN IB(SH) Escin, monosodium salt Escin

AESCIN IIB

ESCIN IIB

06035642G6

b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-

β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-

EscinID

158800-83-0

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract