Chemical Properties Pharmacological Action Escin Ia & Isoescin Ib
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Isoescin IB

Chemical Properties Pharmacological Action Escin Ia & Isoescin Ib
Product Name
Isoescin IB
CAS No.
219944-46-4
Chemical Name
Isoescin IB
Synonyms
Aescin D;Escin IVb;Isoescin Ib;Isoescin IB(Isoaescin IB);Escin Impurity 4(Isoescin IB);Aescin D,Isoescin Ib,Escin ivb;Escin,inhibit,Inhibitor,Escin IB,Isoescin IB;β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-28-(acetyloxy)-16,22,23-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-;(3beta,4beta,16alpha,21beta,22alpha)-28-(Acetyloxy)-16,22,23-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-beta-D-glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranosiduronic acid
CBNumber
CB72554315
Molecular Formula
C55H86O24
Formula Weight
1131.26
MOL File
219944-46-4.mol
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Isoescin IB Property

Boiling point:
1148.1±65.0 °C(Predicted)
Density 
1.46
solubility 
Soluble in methanol;
pka
2.63±0.70(Predicted)
form 
powder
color 
White
Water Solubility 
slightly soluble in water
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL83863
Product name
Isoescin IB
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$709
Updated
2024/03/01
Usbiological
Product number
300477
Product name
Isoescin IB
Packaging
5mg
Price
$490
Updated
2021/12/16
Biorbyt Ltd
Product number
orb259321
Product name
Isoescin IB
Purity
95%
Packaging
10mg
Price
$552.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FI145247
Product name
Isoescin IB
Packaging
2mg
Price
$98.76
Updated
2021/12/16
Biosynth Carbosynth
Product number
FI145247
Product name
Isoescin IB
Packaging
5mg
Price
$197.5
Updated
2021/12/16
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Isoescin IB Chemical Properties,Usage,Production

Chemical Properties

The saponins found in escin exist in two forms, β-escin and α-escin, which can be distinguished by melting point, hemolytic index, specific rotation and solubility in water. β-Escin (mainly consisting of escin Ia and escin Ib) is the major active ingredient in horse chestnut seeds extracts.

Pharmacological Action

Escin exhibits remarkable anti-inflammatory, anti-edematous and vasoprotective properties in a dose-dependent manner which are quite evident at 10-6–10-7 M. Escin has been traditionally used to treat conditions such as chronic venous insufficiency, hemorrhoids, inflammation and cerebral ischemic damage.

Escin Ia & Isoescin Ib

As the minor component of escin, α-escin (mainly consisting of isoescin Ia and isoescin Ib) exhibits lower bioactivity. Similar to isoescin Ia is the isomer of escin Ia, Isoescin Ib is an isomer of escin Ib. Both of them were found to be isomerizable in vitro. Escin Ib and isoescin Ib exhibits stronger pharmacological activity than escin Ia and isoescin Ia. As the result, pharmacokinetics study of them would be helpful for improving the practice of escin application.

Isoescin IB Preparation Products And Raw materials

Raw materials

Preparation Products

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Isoescin IB Suppliers

Jiangxi Baicaoyuan Biotechnology Co. , Ltd.
Tel
0791-82165230 17707911324
Email
2279635539@qq.com
Country
China
ProdList
1387
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Shanghai Winherb Medical Technology Co., Ltd.
Tel
400-400-186-5138 13341702378
Fax
QQ:190129269
Email
winherb@126.com
Country
China
ProdList
1007
Advantage
58
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
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View Lastest Price from Isoescin IB manufacturers

Career Henan Chemical Co
Product
Aescin D 219944-46-4
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-25

219944-46-4, Isoescin IBRelated Search:


  • Aescin D
  • Escin IVb
  • Isoescin Ib
  • Isoescin IB(Isoaescin IB)
  • (3beta,4beta,16alpha,21beta,22alpha)-28-(Acetyloxy)-16,22,23-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-beta-D-glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranosiduronic acid
  • Escin Impurity 4(Isoescin IB)
  • β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-28-(acetyloxy)-16,22,23-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
  • Escin,inhibit,Inhibitor,Escin IB,Isoescin IB
  • Aescin D,Isoescin Ib,Escin ivb
  • 219944-46-4