Ginsenoside Rg3

Product Name: Ginsenoside Rg3
CAS No.: 14197-60-5
Chemical Name: Ginsenoside Rg3
Synonyms: Rg3;CS-1328;gensenoside RG3;GINSENOSIDE RG3;opyransoyl)oxy)-;(20S)-PROPANAXADIOL;20S-Ginseniside Rg3;GINSENOSIDE Rg3(SH);Ginsenosides rg3(s);Ginsenoside Rg3 (S-)
CBNumber: CB9713141
Molecular Formula: C42H72O13
Formula Weight: 785.01
MOL File: 14197-60-5.mol

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Ginsenoside Rg3 Property

Melting point:: 315-318°C
Boiling point:: 885.0±65.0 °C(Predicted)
Density: 1.30
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL
pka: 12.85±0.70(Predicted)
form: powder
color: white to beige
optical activity: [α]/D +10 to +20°, c = 1 in methanol
InChIKey: RWXIFXNRCLMQCD-JBVRGBGGSA-N
CAS DataBase Reference: 14197-60-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: LY9537300
HS Code: 29389090
Toxicity: mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0184
Product name: Ginsenoside Rg3
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $132
Updated: 2025/07/31

Sigma-Aldrich

Product number: 64139
Product name: Ginsenoside Rg3
Purity: analytical standard
Packaging: 10mg
Price: $408
Updated: 2025/07/31

TCI Chemical

Product number: G0568
Product name: 20(S)-Ginsenoside Rg3
Packaging: 10MG
Price: $68
Updated: 2025/07/31

Cayman Chemical

Product number: 15332
Product name: Ginsenoside Rg3
Purity: ≥95%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15332
Product name: Ginsenoside Rg3
Purity: ≥95%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

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Ginsenoside Rg3 Chemical Properties,Usage,Production

Description

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg₃ is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg₃ induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginseng.

Uses

Ginsenoside Rg3 has been used to investigate its modulatory effects on delayed rectifier potassium current (IKr) channels in long QT syndrome (LQTS)2-human induced pluripotent stem cells (hiPSC-CMs).

Uses

Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.

Definition

ChEBI: (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.

Biochem/physiol Actions

Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.

Synthesis

52705-93-8

38243-03-7

14197-60-5

1. Accurately weigh 10 mg of ginsenoside Rd and dispense into five 2 mL cold sterile vials and seal (using screw plugs and silica gel rings). 2. Place the vials containing the sample in a 125 ml glass bottle. 3. Place the above glass vials in a sterilizer (SANYO autoclave, model MLS-3780) and steam treat at 120°C for 2 hours at a pressure of 0.13-0.15 MPa. 4. After 2 hours, one of the samples was removed and the rest of the samples were continued to be steam treated under the same temperature and pressure conditions. 5. The above steps were repeated and the samples were removed at 2 h, 4 h, 6 h, 8 h and 10 h to obtain the treatment products at different time points. 6. Ginsenosides Rd, Rg3-S and Rg3-R were analyzed using HPLC and the results were recorded in Table 2.

in vivo

Ginsenoside Rg3 ((20S)-Rg3) is an Aβ-lowering Natural Compound. APP/PS1 mice are treated with Ginsenoside Rg3 once a day for 4 weeks by intraperitoneal injection (10 mg/kg/day). Aβ ELISA analysis of brain tissues reveal that Ginsenoside Rg3 treatment results in a significant reduction of Aβ40 and Aβ42 in the brain^[4].

IC 50

Na⁺ channel: 32.2 μM (IC₅₀); hKv1.4 channel: 32.6 μM (IC₅₀); p65; COX-2; Aβ40; Aβ42

References

[1] Patent: KR2018/76498, 2018, A. Location in patent: Paragraph 0029; 0031-0043

Ginsenoside Rg3 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ginsenoside Rg3 Suppliers

China 315 Europe 2 Germany 2 India 3 Japan 1 United Kingdom 9 United States 30 Global 362

Bontac Bio-engineering (Shenzhen) Co., Ltd.

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View Lastest Price from Ginsenoside Rg3 manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: GINSENOSIDE Rg3 14197-60-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-29

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Ginsenoside Rg3 14197-60-5
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-10

Shaanxi Haibo Biotechnology Co., Ltd

Product: Ginsenoside Rg3 14197-60-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-08-21

14197-60-5, Ginsenoside Rg3Related Search:

ginsenoside Rh(4) GINSENOSIDE RB2 Ginsenoside Rc Ginsenoside Rb1 Ginseng extract GinsenosideRo Ginsenoside Rg2 PANAX NOTOGINSENOSIDES Ginsenoside Re Ginsenoside Rh2 Escin Ginsenoside Rg1 GINSENOSIDE RE TRIBULOSIDE Ginsenoside Rd Ginsenoside Rf Ginsenoside CK 20(R)-Ginsenoside Rg3

beta-d-glucopyranoside,(3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl2-o-b

dammar-24-ene-12-beta,20-diol,3-beta-((2-o-beta-d-glucopyranosyl-beta-d-gluc

eta-d-glucopyranosyl-

gensenoside RG3

(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside

Rg3

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-DIHYDROXY-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-HYDROXY-17-[(2S)-2-HYDROXY-6-METHYLHEPT-5-EN-2-YL]-4,4,8,10,14-PENTAMETHYL-2,3,5,6,7,9,11,12,13,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-YL]OXY]-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL

Ginsenoside Rg3, 98%, from Panax ginseng C. A. Mey.

(11019-45-7) ginsenoside rg3

Ginsenoside Rg3, ≥98%(HPLC)

2-[[4,5-dihydroxy-2-[[12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)-3-oxany

GINSENOSIDE RG3

CS-1328

Ginsenoside RG3 Natural Plant Extracts HPLC 15% 50% 98% 14197-60-5

opyransoyl)oxy)-

20(s)-ginsenoside-rg3

(20S)-PROPANAXADIOL

Dammar-24-ene-12β,20-diol, 3β-[(2-O-β-D-

glucopyranosyl-β-D-glucopyranosyl)oxy]-

Ginsenoside 20(s)-Rg3

(20S)-3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]dammarane-24-ene-12β,20-diol

12β,20-Dihydroxy-5α-dammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside

20S-Ginseniside Rg3

Ginsenoside Rg3 (S-)

(3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside

GINSENOSIDE RG3(S-FORM)(P)

GINSENOSIDE Rg3(SH)

Ginsenoside Rg3 ,98%

Monomer Ginsenoside Rg3

Ginsenoside Rg3 (S-Form)

β-D-Glucopyranoside, (3β,12β)-12,20-dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-

(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Ginsenosides rg3(s)

Ginsenoside S type Rg3

Ginsenoside Rg3(S-Form)(AS)

20(S)-Ginsenoside Rg3, 10 mM in DMSO

14197-60-5

C42H72O11

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Ginsenoside series

Saponins

The group of Ginsenosides