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Ginsenoside Rg3

Product Name
Ginsenoside Rg3
CAS No.
14197-60-5
Chemical Name
Ginsenoside Rg3
Synonyms
Rg3;CS-1328;gensenoside RG3;GINSENOSIDE RG3;opyransoyl)oxy)-;(20S)-PROPANAXADIOL;20S-Ginseniside Rg3;GINSENOSIDE Rg3(SH);Ginsenosides rg3(s);Ginsenoside Rg3 (S-)
CBNumber
CB9713141
Molecular Formula
C42H72O13
Formula Weight
785.03
MOL File
14197-60-5.mol
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Ginsenoside Rg3 Property

Melting point:
315-318°C
Boiling point:
885.0±65.0 °C(Predicted)
Density 
1.30
storage temp. 
2-8°C
solubility 
DMSO: ≥5mg/mL
pka
12.85±0.70(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D +10 to +20°, c = 1 in methanol
InChIKey
RWXIFXNRCLMQCD-JBVRGBGGSA-N
CAS DataBase Reference
14197-60-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
LY9537300
HS Code 
29389090
Toxicity
mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0184
Product name
Ginsenoside Rg3
Purity
≥98% (HPLC)
Packaging
5mg
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
64139
Product name
Ginsenoside Rg3
Purity
analytical standard
Packaging
10mg
Price
$396
Updated
2024/03/01
Cayman Chemical
Product number
15332
Product name
Ginsenoside Rg3
Purity
≥95%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15332
Product name
Ginsenoside Rg3
Purity
≥95%
Packaging
10mg
Price
$57
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0184
Product name
Ginsenoside Rg3
Purity
≥98% (HPLC)
Packaging
25mg
Price
$531
Updated
2024/03/01
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Ginsenoside Rg3 Chemical Properties,Usage,Production

Description

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg3 is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg3 induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.

Uses

Ginsenoside Rg3 has been used to investigate its modulatory effects on delayed rectifier potassium current (IKr) channels in long QT syndrome (LQTS)2-human induced pluripotent stem cells (hiPSC-CMs).

Uses

Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.

Definition

ChEBI: (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.

Biochem/physiol Actions

Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.

Ginsenoside Rg3 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ginsenoside Rg3 Suppliers

China 234 Europe 2 Germany 2 India 3 Japan 1 United Kingdom 9 United States 31 Global 282
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
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View Lastest Price from Ginsenoside Rg3 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Ginsenoside Rg3 14197-60-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000ton
Release date
2023-08-21
Shanghai Standard Technology Co., Ltd.
Product
Ginsenoside Rg3 14197-60-5
Price
US $0.00/mg
Min. Order
5mg
Purity
≥96%(HPLC)
Supply Ability
10 g
Release date
2019-10-29
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Ginsenoside Rg3 14197-60-5
Price
US $80.00/g
Min. Order
1KG
Purity
95%
Supply Ability
50kg
Release date
2020-03-04

14197-60-5, Ginsenoside Rg3Related Search:

ginsenoside Rh(4) GINSENOSIDE RB2 Ginsenoside Rc Ginsenoside Rb1 Ginseng extract GinsenosideRo Ginsenoside Rg2 PANAX NOTOGINSENOSIDES Ginsenoside Re Ginsenoside Rh2 Escin Ginsenoside Rg1 GINSENOSIDE RE TRIBULOSIDE Ginsenoside Rd Ginsenoside Rf Ginsenoside CK 20(R)-Ginsenoside Rg3

  • beta-d-glucopyranoside,(3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl2-o-b
  • dammar-24-ene-12-beta,20-diol,3-beta-((2-o-beta-d-glucopyranosyl-beta-d-gluc
  • eta-d-glucopyranosyl-
  • gensenoside RG3
  • (3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
  • Rg3
  • (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-DIHYDROXY-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-HYDROXY-17-[(2S)-2-HYDROXY-6-METHYLHEPT-5-EN-2-YL]-4,4,8,10,14-PENTAMETHYL-2,3,5,6,7,9,11,12,13,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-YL]OXY]-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL
  • Ginsenoside Rg3, 98%, from Panax ginseng C. A. Mey.
  • (11019-45-7) ginsenoside rg3
  • Ginsenoside Rg3, ≥98%(HPLC)
  • 2-[[4,5-dihydroxy-2-[[12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)-3-oxany
  • GINSENOSIDE RG3
  • CS-1328
  • Ginsenoside RG3 Natural Plant Extracts HPLC 15% 50% 98% 14197-60-5
  • opyransoyl)oxy)-
  • 20(s)-ginsenoside-rg3
  • (20S)-PROPANAXADIOL
  • Dammar-24-ene-12β,20-diol, 3β-[(2-O-β-D-
  • glucopyranosyl-β-D-glucopyranosyl)oxy]-
  • Ginsenoside 20(s)-Rg3
  • (20S)-3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]dammarane-24-ene-12β,20-diol
  • 12β,20-Dihydroxy-5α-dammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
  • 20S-Ginseniside Rg3
  • Ginsenoside Rg3 (S-)
  • (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside
  • GINSENOSIDE RG3(S-FORM)(P)
  • GINSENOSIDE Rg3(SH)
  • Ginsenoside Rg3 ,98%
  • Monomer Ginsenoside Rg3
  • Ginsenoside Rg3 (S-Form)
  • β-D-Glucopyranoside, (3β,12β)-12,20-dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-
  • (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • Ginsenosides rg3(s)
  • Ginsenoside S type Rg3
  • Ginsenoside Rg3(S-Form)(AS)
  • 14197-60-5
  • C42H72O11
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Ginsenoside series
  • Saponins
  • The group of Ginsenosides