Ginsenoside Rg3

ChemicalBook > CAS DataBase List > Ginsenoside Rg3

Product Name: Ginsenoside Rg3
CAS No.: 14197-60-5
Chemical Name: Ginsenoside Rg3
Synonyms: Rg3;CS-1328;gensenoside RG3;GINSENOSIDE RG3;opyransoyl)oxy)-;(20S)-PROPANAXADIOL;20S-Ginseniside Rg3;GINSENOSIDE Rg3(SH);Ginsenosides rg3(s);Ginsenoside Rg3 (S-)
CBNumber: CB9713141
Molecular Formula: C42H72O13
Formula Weight: 785.03
MOL File: 14197-60-5.mol

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Ginsenoside Rg3 Property

Melting point:: 315-318°C
Boiling point:: 885.0±65.0 °C(Predicted)
Density: 1.30
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL
pka: 12.85±0.70(Predicted)
form: powder
color: white to beige
optical activity: [α]/D +10 to +20°, c = 1 in methanol
InChIKey: RWXIFXNRCLMQCD-JBVRGBGGSA-N
CAS DataBase Reference: 14197-60-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: LY9537300
HS Code: 29389090
Toxicity: mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0184
Product name: Ginsenoside Rg3
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $128
Updated: 2024/03/01

Sigma-Aldrich

Product number: 64139
Product name: Ginsenoside Rg3
Purity: analytical standard
Packaging: 10mg
Price: $396
Updated: 2024/03/01

Cayman Chemical

Product number: 15332
Product name: Ginsenoside Rg3
Purity: ≥95%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15332
Product name: Ginsenoside Rg3
Purity: ≥95%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0184
Product name: Ginsenoside Rg3
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $531
Updated: 2024/03/01

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Ginsenoside Rg3 Chemical Properties,Usage,Production

Description

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg₃ is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg₃ induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.

Uses

Ginsenoside Rg3 has been used to investigate its modulatory effects on delayed rectifier potassium current (IKr) channels in long QT syndrome (LQTS)2-human induced pluripotent stem cells (hiPSC-CMs).

Uses

Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.

Definition

ChEBI: (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.

Biochem/physiol Actions

Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.

Ginsenoside Rg3 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ginsenoside Rg3 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Ginsenoside Rg3 14197-60-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-08-21

Shanghai Standard Technology Co., Ltd.

Product: Ginsenoside Rg3 14197-60-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥96%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-29

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Ginsenoside Rg3 14197-60-5
Price: US $80.00/g
Min. Order: 1KG
Purity: 95%
Supply Ability: 50kg
Release date: 2020-03-04

14197-60-5, Ginsenoside Rg3Related Search:

ginsenoside Rh(4) GINSENOSIDE RB2 Ginsenoside Rc Ginsenoside Rb1 Ginseng extract GinsenosideRo Ginsenoside Rg2 PANAX NOTOGINSENOSIDES Ginsenoside Re Ginsenoside Rh2 Escin Ginsenoside Rg1 GINSENOSIDE RE TRIBULOSIDE Ginsenoside Rd Ginsenoside Rf Ginsenoside CK 20(R)-Ginsenoside Rg3

beta-d-glucopyranoside,(3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl2-o-b

dammar-24-ene-12-beta,20-diol,3-beta-((2-o-beta-d-glucopyranosyl-beta-d-gluc

eta-d-glucopyranosyl-

gensenoside RG3

(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside

Rg3

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-DIHYDROXY-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-HYDROXY-17-[(2S)-2-HYDROXY-6-METHYLHEPT-5-EN-2-YL]-4,4,8,10,14-PENTAMETHYL-2,3,5,6,7,9,11,12,13,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-YL]OXY]-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL

Ginsenoside Rg3, 98%, from Panax ginseng C. A. Mey.

(11019-45-7) ginsenoside rg3

Ginsenoside Rg3, ≥98%(HPLC)

2-[[4,5-dihydroxy-2-[[12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)-3-oxany

GINSENOSIDE RG3

CS-1328

Ginsenoside RG3 Natural Plant Extracts HPLC 15% 50% 98% 14197-60-5

opyransoyl)oxy)-

20(s)-ginsenoside-rg3

(20S)-PROPANAXADIOL

Dammar-24-ene-12β,20-diol, 3β-[(2-O-β-D-

glucopyranosyl-β-D-glucopyranosyl)oxy]-

Ginsenoside 20(s)-Rg3

(20S)-3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]dammarane-24-ene-12β,20-diol

12β,20-Dihydroxy-5α-dammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside

20S-Ginseniside Rg3

Ginsenoside Rg3 (S-)

(3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside

GINSENOSIDE RG3(S-FORM)(P)

GINSENOSIDE Rg3(SH)

Ginsenoside Rg3 ,98%

Monomer Ginsenoside Rg3

Ginsenoside Rg3 (S-Form)

β-D-Glucopyranoside, (3β,12β)-12,20-dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-

(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Ginsenosides rg3(s)

Ginsenoside S type Rg3

14197-60-5

C42H72O11

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Ginsenoside series

Saponins

The group of Ginsenosides