METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE
- Product Name
- METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE
- CAS No.
- 307353-32-8
- Chemical Name
- METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE
- Synonyms
- METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE;3-Bromo-5-hydroxymethyl-benzoic acid methyl ester;Benzoic acid, 3-bromo-5-(hydroxymethyl)-, methyl ester
- CBNumber
- CB62455255
- Molecular Formula
- C9H9BrO3
- Formula Weight
- 245.07
- MOL File
- 307353-32-8.mol
METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE Property
- Boiling point:
- 354.2±32.0 °C(Predicted)
- Density
- 1.557±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.08±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H9BrO3/c1-13-9(12)7-2-6(5-11)3-8(10)4-7/h2-4,11H,5H2,1H3
- InChIKey
- PWAJHVDGAMQOPF-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC(CO)=CC(Br)=C1
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-B1348
- Product name
- Methyl3-bromo-5-(hydroxymethyl)benzoate
- Purity
- 96.56%
- Packaging
- 250mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 2629-9-40
- Product name
- Methyl 3-Bromo-5-(hydroxymethyl)benzoate
- Packaging
- 250mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- CS-B1348
- Product name
- Methyl3-bromo-5-(hydroxymethyl)benzoate
- Purity
- 96.56%
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 2629-9-40
- Product name
- Methyl 3-Bromo-5-(hydroxymethyl)benzoate
- Packaging
- 1g
- Price
- $228
- Updated
- 2021/12/16
- Product number
- CS-B1348
- Product name
- Methyl3-bromo-5-(hydroxymethyl)benzoate
- Purity
- 96.56%
- Packaging
- 10g
- Price
- $855
- Updated
- 2021/12/16
METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE Chemical Properties,Usage,Production
Synthesis
220286-47-5
307353-32-8
General procedure for the synthesis of methyl 3-bromo-5-(hydroxymethyl)benzoate from methyl 3-amino-5-(hydroxymethyl)benzoate: Methyl 3-amino-5-(hydroxymethyl)benzoate (2.4 g, 13.2 mmol) was dissolved in anhydrous acetonitrile (10 mL) and slowly added dropwise to a solution of acetonitrile (20 mL) containing copper(II) bromide (3.54 g, 15.8 mmol) and tert-butyl nitrite (2.24 mL, 18.9 mmol). (2.24 mL, 18.9 mmol) in acetonitrile (20 mL), and the reaction temperature was maintained at 65 °C. The reaction mixture was stirred at 65 °C. The reaction mixture was stirred at 65 °C for 30 min, then cooled to room temperature and subsequently poured into 1N hydrochloric acid solution and extracted with ether. The organic layers were combined, washed with brine (2 times), dried over anhydrous sodium sulfate and concentrated. Purification by silica gel column chromatography (eluent: 30% ethyl acetate/hexane) afforded the target product methyl 3-bromo-5-(hydroxymethyl)benzoate 2.0 g in 62% yield. The product was identified by 1H-NMR (CDCl3, 300 MHz): δ 8.04 (s, 1H), 7.90 (s, 1H), 7.69 (s, 1H), 4.70 (s, 2H), 3.89 (s, 3H). Mass spectrometry analysis showed a molecular ion peak of 246.98 (MH)+.
References
[1] Patent: US2007/249607, 2007, A1. Location in patent: Page/Page column 85
METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE Suppliers
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- Fax
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- sales@ajchem.in
- Country
- India
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View Lastest Price from METHYL 3-BROMO-5-(HYDROXYMETHYL)BENZOATE manufacturers
- Product
- methyl 3-bromo-5-(hydroxymethyl)benzoate 307353-32-8
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-05-12