2-BROMO-5-IODOBENZYL ALCOHOL
- Product Name
- 2-BROMO-5-IODOBENZYL ALCOHOL
- CAS No.
- 946525-30-0
- Chemical Name
- 2-BROMO-5-IODOBENZYL ALCOHOL
- Synonyms
- JAK-IN-24;2-BROMO-5-IODOBENZYL ALCOHOL;2-bromo-5-iodobenzenemethanol;(2-Bromo-5-iodophenyl)methanol;Benzenemethanol, 2-bromo-5-iodo-;4-bromo-3-hydroxymethyl-1-iodo-benzene;(2-Bromo-5-iodophenyl)methanol, 98%min
- CBNumber
- CB62455538
- Molecular Formula
- C7H6BrIO
- Formula Weight
- 312.93
- MOL File
- 946525-30-0.mol
2-BROMO-5-IODOBENZYL ALCOHOL Property
- Melting point:
- 112-116°C
- Boiling point:
- 343.3±32.0 °C(Predicted)
- Density
- 2.211±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- crystalline solid
- pka
- 13.67±0.10(Predicted)
- color
- Cream/faint lemon
- InChI
- InChI=1S/C7H6BrIO/c8-7-2-1-6(9)3-5(7)4-10/h1-3,10H,4H2
- InChIKey
- WDXHGFYJUQMFDV-UHFFFAOYSA-N
- SMILES
- C1(CO)=CC(I)=CC=C1Br
Safety
- WGK Germany
- 3
- HS Code
- 2906290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 748498
- Product name
- 2-Bromo-5-iodobenzyl alcohol
- Purity
- 97%
- Packaging
- 5g
- Price
- $59.2
- Updated
- 2025/07/31
- Product number
- B687558
- Product name
- (2-Bromo-5-iodophenyl)methanol
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- AK158350
- Product name
- (2-Bromo-5-iodophenyl)methanol
- Purity
- 98%
- Packaging
- 10g
- Price
- $46
- Updated
- 2021/12/16
- Product number
- 2601-S-01
- Product name
- 2-Bromo-5-iodobenzyl alcohol
- Packaging
- 25g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- AK158350
- Product name
- (2-Bromo-5-iodophenyl)methanol
- Purity
- 98%
- Packaging
- 100g
- Price
- $238
- Updated
- 2021/12/16
2-BROMO-5-IODOBENZYL ALCOHOL Chemical Properties,Usage,Production
Synthesis
25252-00-0
946525-30-0
General procedure for the synthesis of 2-bromo-5-iodobenzyl alcohol from 2-bromo-5-iodobenzoic acid: Tetrahydrofuran (99.7 g) and sodium borohydride (15.2 g, 0.4 mol) were added to a reaction flask, followed by a solution of tetrahydrofuran (151 g) of 2-bromo-5-iodobenzoic acid (109.4 g, 0.34 mol, prepared according to Example 2), and the temperature was controlled to be in the range of 10-25°C. A solution of tetrahydrofuran (25 g) of sulfuric acid (16.4 g) was added slowly and dropwise to the reaction vessel at 10-30°C. -25°C. A tetrahydrofuran (25 g) solution of sulfuric acid (16.4 g) was slowly added dropwise at 10-30°C to the reaction vessel. After the dropwise addition was completed, the reaction was carried out at room temperature for 2 hours. Subsequently, the reaction mixture was heated to 66°C and refluxed for 2 hours and then cooled to room temperature. 5% hydrochloric acid (235 g) was slowly added dropwise, followed by distillation under reduced pressure (~0.01 MPa) to remove the tetrahydrofuran. Methyl tert-butyl ether (326.7 g) and water (222.7 g) were added to dissolve the solids and after cooling to 15-25°C, the organic layer was separated and evaporated under reduced pressure (-0.095 MPa). Toluene (108.8 g) and water (108.8 g) were added and the mixture was heated to 60°C and kept for 1 hr, then cooled to 18-22°C. It was filtered and dried to give 89.1 g of an off-white solid product, which was assayed to contain >99%, giving a yield of 85.1%.
References
[1] Patent: CN107954861, 2018, A. Location in patent: Paragraph 0096; 0097
[2] Patent: WO2018/15410, 2018, A1. Location in patent: Paragraph 0304-0307
[3] Patent: US2014/31540, 2014, A1. Location in patent: Paragraph 0072; 0073; 0074
[4] Patent: WO2014/16381, 2014, A1. Location in patent: Page/Page column 12
[5] Patent: WO2014/161836, 2014, A1. Location in patent: Page/Page column 42
2-BROMO-5-IODOBENZYL ALCOHOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-5-IODOBENZYL ALCOHOL manufacturers
- Product
- 2-Bromo-5-iodobenzyl alcohol 946525-30-0
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-29
- Product
- 2-BROMO-5-IODOBENZYL ALCOHOL 946525-30-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-10
- Product
- 2-Bromo-5-iodobenzyl alcohol 946525-30-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08