2-BROMO-5-METHOXYPYRIDINE
- Product Name
- 2-BROMO-5-METHOXYPYRIDINE
- CAS No.
- 105170-27-2
- Chemical Name
- 2-BROMO-5-METHOXYPYRIDINE
- Synonyms
- 2-BROMO-5-METHOXYPYRIDINE;Pyridine,2-bromo-5-methoxy-;2-Bromo-5-methoxypyridine, 98%;2-BROMO-5-METHOXYPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB2212539
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 105170-27-2.mol
2-BROMO-5-METHOXYPYRIDINE Property
- Melting point:
- 22 °C
- Boiling point:
- 113 °C(Press: 59 Torr)
- Density
- 1.530±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to lump
- pka
- -2.22±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C6H6BrNO/c1-9-5-2-3-6(7)8-4-5/h2-4H,1H3
- InChIKey
- WULVUFYZVYHTFX-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=C(OC)C=C1
- CAS DataBase Reference
- 105170-27-2
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B5910
- Product name
- 2-Bromo-5-methoxypyridine
- Packaging
- 1G
- Price
- $34
- Updated
- 2025/07/31
- Product number
- B5910
- Product name
- 2-Bromo-5-methoxypyridine
- Packaging
- 5G
- Price
- $136
- Updated
- 2025/07/31
- Product number
- B685710
- Product name
- 2-Bromo-5-methoxypyridine
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- B685710
- Product name
- 2-Bromo-5-methoxypyridine
- Packaging
- 5g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- B685710
- Product name
- 2-Bromo-5-methoxypyridine
- Packaging
- 25g
- Price
- $1090
- Updated
- 2021/12/16
2-BROMO-5-METHOXYPYRIDINE Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Uses
2-Bromo-5-methoxypyridine is a reagent used in preparation of tetrahydroisoquinoline amides as bronchodilators.
Synthesis
10167-97-2
105170-27-2
General procedure for the synthesis of 2-bromo-5-methoxypyridine from 2-amino-5-methoxypyridine: (a) 2-Amino-5-methoxypyridine (14.8 g, prepared according to the method described by JG Lombardino, J. Med. Chem., 1981, 24, 39) was dissolved in 60% hydrobromic acid (150 ml) and cooled to -10°C. Bromine (47.47 g) was added slowly and dropwise with stirring. A solution of sodium nitrite (20.53 g) in water (40 ml) was added dropwise to the resulting yellow suspension, keeping the reaction temperature below -5°C. The mixture was stirred to room temperature and cooled to 0°C after 0.5 h. A solution of sodium hydroxide (120 g) in water (100 ml) was added slowly. The mixture was fully extracted with ether, the ether extracts were combined and dried with anhydrous sodium sulfate, followed by evaporation of the solvent. The residue was purified by column chromatography on silica gel (150 g), using dichloromethane as eluent to give a yellow oil (14.1 g, 63% yield). This product was combined with a smaller batch (3.4 g) and purified by distillation under reduced pressure to give finally 2-bromo-5-methoxypyridine (16.4 g) with a boiling point of 76°C-78°C/0.6 torr.
References
[1] Pharmazie, 2000, vol. 55, # 12, p. 907 - 912
[2] Patent: US4766121, 1988, A
[3] Patent: EP188351, 1991, B1
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 3085 - 3096
2-BROMO-5-METHOXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-BROMO-5-METHOXYPYRIDINE Suppliers
- Tel
- 021-31137757-00; 18121466954
- Fax
- 021-64902762
- 28328681@qq.com
- Country
- China
- ProdList
- 180
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2807
- Advantage
- 65
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
View Lastest Price from 2-BROMO-5-METHOXYPYRIDINE manufacturers
- Product
- 2-BROMO-5-METHOXYPYRIDINE 105170-27-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 2-BROMO-5-METHOXYPYRIDINE 105170-27-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06