3-BROMO-2-CHLORO-6-METHOXYPYRIDINE

Uses Application

Product Name: 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE
CAS No.: 777931-67-6
Chemical Name: 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE
Synonyms: EOS-61428;2-Chloro-3-bromo-6-methoxypyridine;Pyridine, 3-bromo-2-chloro-6-methoxy-
CBNumber: CB62457956
Molecular Formula: C6H5BrClNO
Formula Weight: 222.47
MOL File: 777931-67-6.mol

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3-BROMO-2-CHLORO-6-METHOXYPYRIDINE Property

Boiling point:: 243.8±35.0 °C(Predicted)
Density: 1.650±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.37±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B690368
Product name: 3-Bromo-2-chloro-6-methoxypyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B690368
Product name: 3-Bromo-2-chloro-6-methoxypyridine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-D-38
Product name: 3-Bromo-2-chloro-6-methoxypyridine
Purity: 98%
Packaging: 1g
Price: $104
Updated: 2021/12/16

Matrix Scientific

Product number: 150273
Product name: 3-Bromo-2-chloro-6-methoxypyridine
Purity: 95%
Packaging: 1g
Price: $319
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0364407
Product name: 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $497.27
Updated: 2021/12/16

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3-BROMO-2-CHLORO-6-METHOXYPYRIDINE Chemical Properties,Usage,Production

Uses

2-Chloro-6-methoxy-3-bromopyridine can be used as a pharmaceutical synthesis intermediate.

Application

2-Chloro-6-methoxy-3-bromopyridine can be used as a pharmaceutical synthesis intermediate, such as in the preparation of 2-(6-(1-ethyl-4-fluoro-1H-indazol-6-yl)-2-methoxypyridin-3-yl)-3-methylbutanal: In a 100 mL vial maintained under an inert nitrogen atmosphere, 2-chloro-6-methoxy-3-bromopyridine (2.00 g, 8.900 mmol, 1.00 equivalent) was added, along with Pd(dppf)Cl2.CH2Cl2 (0.36 g, 0.450 mmol, 0.05 equivalent) and Zn(CH3)2 (17 mL, 17.000 mmol, 2.00 equivalent) were added to a solution in 20 mL of 1,4-dioxane. The resulting solution was stirred at 90 °C for 16 h. The mixture was then concentrated under vacuum. The residue was purified by silica gel chromatography and further purified with ethyl acetate/petroleum ether (2:98) to give 2-(6-(1-ethyl-4-fluoro-1H-indazole-6-yl)-2-methoxypyridin-3-yl)-3-methylbutanal as a yellow oil.

Synthesis

17228-64-7

777931-67-6

General procedure for the synthesis of 2-chloro-3-bromo-6-methoxypyridine from 2-chloro-6-methoxypyridine: To a stirred solution of 2-chloro-6-methoxypyridine (7.00 g, 48.8 mmol) in acetonitrile (25 mL) was added N-bromosuccinimide (NBS, 13.0 g, 73.1 mmol) at room temperature. The reaction mixture was refluxed for 24 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium thiosulfate (Na2S2O3) and extracted with ethyl acetate (EtOAc). The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel, hexane-ethyl acetate = 98:2) afforded 2-chloro-3-bromo-6-methoxypyridine (6.83 g, 63% yield) as a colorless solid. The product was characterized by the following data: melting point 64-65 °C; IR spectra (film, cm-1 ): 1584, 1551, 1466, 1408, 1344, 1306, 1256, 1155, 1121, 1022, 1009; 1H-NMR (CDCl3, 500 MHz) δ: 7.72 (d, J = 8.50 Hz, 1H), and 6.58 (d, J = 8.50 Hz, 1H), 3.92 (s, 3H); 13C-NMR (CDCl3, 125 MHz) δ: 162.4, 147.3, 143.8, 110.9, 110.1, 54.3; High-resolution mass spectrometry (ESI-TOF): the calculated value C6H6BrClNO [(M + H)+ ] was 221.9316, and the measured value was 221.9314.

References

[1] MedChemComm, 2017, vol. 8, # 4, p. 796 - 806
[2] Organic Letters, 2014, vol. 16, # 7, p. 1980 - 1983
[3] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 7, p. 723 - 732

3-BROMO-2-CHLORO-6-METHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-2-CHLORO-6-METHOXYPYRIDINE Suppliers

China 86 India 3 United Kingdom 1 United States 11 Global 101

Accela ChemBio Inc.

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View Lastest Price from 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE manufacturers

Career Henan Chemical Co

Product: 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE 777931-67-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10T
Release date: 2019-12-25

777931-67-6, 3-BROMO-2-CHLORO-6-METHOXYPYRIDINERelated Search:

6-Methoxynicotinaldehyde 4-CHLORO-2-METHOXY-PYRIDINE 3-BROMO-2-CHLORO-6-ISOPROPOXYPYRIDINE 3-BROMO-2-CHLORO-6-METHOXYPYRIDINE

EOS-61428

Pyridine, 3-bromo-2-chloro-6-methoxy-

2-Chloro-3-bromo-6-methoxypyridine

777931-67-6

alkyl bromide|alkyl chloride