ChemicalBook > CAS DataBase List > 2'-O-MOE-5MeU-3'-phosphoramidite

2'-O-MOE-5MeU-3'-phosphoramidite

Product Name
2'-O-MOE-5MeU-3'-phosphoramidite
CAS No.
163878-63-5
Chemical Name
2'-O-MOE-5MeU-3'-phosphoramidite
Synonyms
5-Me-DMT-2'-O-Me-Ur;5'-O-DMT-2'-O-MOE-T-CE;5-Me-DMT-2'-O-MOE-U-CE;5'-O-DMT-2'-O-MOE-T-CE;2'-MOE Thymidine Amidite;2'-MOE-U CE Phosphoramidite;2'-MOE-U CE Phosphoramidite;5-Methyl-2 '- Methoxyuridine;2'-O-MOE-T-CE Phosphoramidite;2'-O-MOE-5-Me-U Phosphoramidite
CBNumber
CB62459682
Molecular Formula
C43H55N4O10P
Formula Weight
818.89
MOL File
163878-63-5.mol
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2'-O-MOE-5MeU-3'-phosphoramidite Property

pka
9.55±0.10(Predicted)
InChI
InChI=1/C43H55N4O10P/c1-29(2)47(30(3)4)58(55-24-12-23-44)57-38-37(56-41(39(38)53-26-25-50-6)46-27-31(5)40(48)45-42(46)49)28-54-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,27,29-30,37-39,41H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38-,39-,41-,58?/s3
InChIKey
YFRRKZDUDXHJNC-UHDLEJOUNA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,37,43,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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2'-O-MOE-5MeU-3'-phosphoramidite Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

5''-O-DMT-2''-O-methyl-5-methyluridine is a uridine-derived oligonucleoside (U829910) used in the synthetic preparation of nucleic acids.

General Description

2'-O-MOE-5MeU-3'-phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

General Description

Like the very similar 2’-OMe backbone, the 2’-O-methoxyethyl-RNA (2’-MOE) backbone provides enhanced duplex stability, significant nuclease resistance and relatively low toxicity. As a result, 2’-MOE has been an attractive backbone for many therapeutic candidates, several of which have been approved by the FDA. These drugs have included 1) 2’-MOE/DNA chimeras to facilitate RNase H cleavage of target RNA sequences as well as 2) steric blocking oligonucleotides to alter the splicing of mRNA. The standard 2’-MOE nucleotides are A, 5-Me-C, G and 5-Me-U.

2'-O-MOE-5MeU-3'-phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-MOE-5MeU-3'-phosphoramidite Suppliers

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View Lastest Price from 2'-O-MOE-5MeU-3'-phosphoramidite manufacturers

SHANGHAI NOVRIBO BIOTECH
Product
2'-MOE-U CE Phosphoramidite 163878-63-5
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-20
Hefei Huana Biomedical Technology Co.,Ltd.
Product
5'-O-DMT-2'-O-MOE-T-CE 163878-63-5
Price
US $0.00/mg
Min. Order
100mg
Purity
≥98%
Supply Ability
20tons
Release date
2023-03-09
Henan Aochuang Chemical Co.,Ltd.
Product
5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine 3'-CE phosphoramidite 163878-63-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26

163878-63-5, 2'-O-MOE-5MeU-3'-phosphoramiditeRelated Search:

N2-iso-Butyroyl-5'-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 2'-O-TBDMS-5'-O-DMT-N4-Ac cytidin 5'-O-DMT-2'-O-methyl-N6-phenoxyacetyl-D-adenosine

  • 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • (2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-4-(2-METHOXYETHOXY)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
  • 2-O-MOE-5-Methyl-Uridine Phosphoramidite
  • 5'-O-DMT-2'-O-methyl-5-methyluridine
  • 5-Me-DMT-2'-O-Me-Ur
  • 5-Methyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine
  • 2'-O-MOE-5MeU-3'-phosphoramidite
  • 5'-O-DMTR-2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE-3'-CED-PHOSPHORAMIDITE
  • 2'-O-MOE-T-CE Phosphoramidite
  • 5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-uridine-3'-cyanoethyl Phosphoramidite
  • DMT-2'-O-MOE-T-CE-Phosphoramidite
  • Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 5’-O-DMTr-2’-O-(2-methoxyethyl)-5-methyluridine-3’-CED-phosphoramidite, 2’-O-MOE -5MeU-3’-phosphoramidite
  • 5'-O-DMT-5-Methy-2'-O-(2-methoxyethyl)uridine 3'-CE phosphoramidite
  • 2'-O-MOE-5-Me-U Phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • DMT-2′O-MOE-rMeU Phosphoramidite
  • 5'-O-DMT-2’-MOE-5-methyluridine-CE-Phosphoramidite
  • 5-Me-DMT-2'-O-MOE-U-CE-Phosphoramidite
  • 2’-O-MOE-5MeU-3’-phosphoramidite,5’-O-DMTr-2’-O-(2-methoxyethyl)-5-methyl uridine-3’-CED-phosphoramidite MOE-5MeU-PAM
  • 2’-O-MOE-5MeU-3’-phosphoramidit
  • 5'-O-DMT-2'-O-MOE-T-CE
  • 2'-O-MOE-5-Me-U -CE Phosphoramidite
  • 2'-MOE-U CE Phosphoramidite
  • 5'-O-DMT-2'-O-MOE- 5-Me-Uridine -3’-Cyanoethyl Phosphoramidite
  • 2'-MOE Thymidine Amidite
  • 5-Me-DMT-2'-O-MOE-U-CE
  • DMT-2''O-MOE-rMeU Amidite，septum
  • 5-Methyl-2 '- Methoxyuridine
  • DMTr-2'-O-MOE-rT-3'-CE-Phosphoramidite
  • 2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
  • 5’-O-(4, 4’-Dimethoxytrityl)-5-methyl-2’-O-(2-methoxyethyl)uridine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-ODMT-2'-OMOE-5-methyluridine-3'-OCEPA
  • 2’-O-MOE-5MeU-3’-phospho ramidite
  • DMT-2'-O-MOE-T-CE-Phosphoramidite
  • 2'-MOE-U CE Phosphoramidite
  • 5'-O-DMT-2'-O-MOE-T-CE
  • 2'-O-MOE-5-Me-U-CE-Phosphoramidite
  • 163878-63-5
  • C43H55N4O10P
  • Amidite