ChemicalBook > CAS DataBase List > 2'-O-MOE-5MeU-3'-phosphoramidite

2'-O-MOE-5MeU-3'-phosphoramidite

Product Name
2'-O-MOE-5MeU-3'-phosphoramidite
CAS No.
163878-63-5
Chemical Name
2'-O-MOE-5MeU-3'-phosphoramidite
Synonyms
5-Me-DMT-2'-O-Me-Ur;5'-O-DMT-2'-O-MOE-T-CE;5-Me-DMT-2'-O-MOE-U-CE;5'-O-DMT-2'-O-MOE-T-CE;2'-MOE Thymidine Amidite;2'-MOE Thymidine Amidite;2'-MOE-U CE Phosphoramidite;2'-MOE-U CE Phosphoramidite;5-Methyl-2 '- Methoxyuridine;2'-O-MOE-T-CE Phosphoramidite
CBNumber
CB62459682
Molecular Formula
C43H55N4O10P
Formula Weight
818.89
MOL File
163878-63-5.mol
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2'-O-MOE-5MeU-3'-phosphoramidite Property

pka
9.55±0.10(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1/C43H55N4O10P/c1-29(2)47(30(3)4)58(55-24-12-23-44)57-38-37(56-41(39(38)53-26-25-50-6)46-27-31(5)40(48)45-42(46)49)28-54-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,27,29-30,37-39,41H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38-,39-,41-,58?/s3
InChIKey
YFRRKZDUDXHJNC-UHDLEJOUNA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,37,43,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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2'-O-MOE-5MeU-3'-phosphoramidite Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

5''-O-DMT-2''-O-methyl-5-methyluridine is a uridine-derived oligonucleoside (U829910) used in the synthetic preparation of nucleic acids.

General Description

2'-O-MOE-5MeU-3'-phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

General Description

Like the very similar 2’-OMe backbone, the 2’-O-methoxyethyl-RNA (2’-MOE) backbone provides enhanced duplex stability, significant nuclease resistance and relatively low toxicity. As a result, 2’-MOE has been an attractive backbone for many therapeutic candidates, several of which have been approved by the FDA. These drugs have included 1) 2’-MOE/DNA chimeras to facilitate RNase H cleavage of target RNA sequences as well as 2) steric blocking oligonucleotides to alter the splicing of mRNA. The standard 2’-MOE nucleotides are A, 5-Me-C, G and 5-Me-U.

2'-O-MOE-5MeU-3'-phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-MOE-5MeU-3'-phosphoramidite Suppliers

China 91 India 3 United Kingdom 1 United States 4 Global 99
Hefei Huana Biomedical Technology Co.,Ltd
Tel
17333066501
Email
shengwen.fang@huanaok.com.cn
Country
China
ProdList
95
Advantage
58
Hefei Stongbio Co.,Ltd.
Tel
15555170917
Email
sales@stongbio.com
Country
China
ProdList
490
Advantage
58
Wuhu Huaren Science and Technology Co., Ltd.
Tel
0553-0553-0553-5842013-801-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
Country
China
ProdList
295
Advantage
64
Chemyouth Life Science（Suzhou）Co.,Ltd
Tel
0512-52112288 13752065514
Email
jianwei@chemyouth.com
Country
China
ProdList
49
Advantage
58
Jiangsu Synthgene Biotechnology Co.,Ltd.
Tel
18136497538
Email
znf@syngenebio.com
Country
China
ProdList
901
Advantage
58
Asymchem Labs.
Tel
17347534561
Email
liujingjing0710@asymchem.com.cn
Country
China
ProdList
432
Advantage
58
Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Zhengzhou GranLen pharmaceutical Technology Co., Ltd.
Tel
0371-85513397
Email
info@granlen.com
Country
China
ProdList
497
Advantage
55
Wuhan Chemduro Pharm Tech Co. Ltd.
Tel
18040571231/1402788087
Fax
sales@chemduro.com
Country
China
ProdList
1973
Advantage
58
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View Lastest Price from 2'-O-MOE-5MeU-3'-phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
5'-O-DMT-2'-O-MOE-T-CE 163878-63-5
Price
US $0.00/mg
Min. Order
100mg
Purity
≥98%
Supply Ability
20tons
Release date
2023-03-09
SHANGHAI NOVRIBO BIOTECH
Product
2'-MOE-U CE Phosphoramidite 163878-63-5
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-20
Henan Aochuang Chemical Co.,Ltd.
Product
5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine 3'-CE phosphoramidite 163878-63-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26

163878-63-5, 2'-O-MOE-5MeU-3'-phosphoramiditeRelated Search:

N2-iso-Butyroyl-5'-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 2'-O-TBDMS-5'-O-DMT-N4-Ac cytidin 5'-O-DMT-2'-O-methyl-N6-phenoxyacetyl-D-adenosine

  • 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • (2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-4-(2-METHOXYETHOXY)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
  • 2-O-MOE-5-Methyl-Uridine Phosphoramidite
  • 5'-O-DMT-2'-O-methyl-5-methyluridine
  • 5-Me-DMT-2'-O-Me-Ur
  • 5-Methyl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-uridine
  • 2'-O-MOE-5MeU-3'-phosphoramidite
  • 5'-O-DMTR-2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE-3'-CED-PHOSPHORAMIDITE
  • 2'-O-MOE-T-CE Phosphoramidite
  • 5-methyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-uridine-3'-cyanoethyl Phosphoramidite
  • DMT-2'-O-MOE-T-CE-Phosphoramidite
  • Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 5’-O-DMTr-2’-O-(2-methoxyethyl)-5-methyluridine-3’-CED-phosphoramidite, 2’-O-MOE -5MeU-3’-phosphoramidite
  • 5'-O-DMT-5-Methy-2'-O-(2-methoxyethyl)uridine 3'-CE phosphoramidite
  • 2'-O-MOE-5-Me-U Phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • DMT-2′O-MOE-rMeU Phosphoramidite
  • 5'-O-DMT-2’-MOE-5-methyluridine-CE-Phosphoramidite
  • 5-Me-DMT-2'-O-MOE-U-CE-Phosphoramidite
  • 2’-O-MOE-5MeU-3’-phosphoramidite,5’-O-DMTr-2’-O-(2-methoxyethyl)-5-methyl uridine-3’-CED-phosphoramidite MOE-5MeU-PAM
  • 2’-O-MOE-5MeU-3’-phosphoramidit
  • 5'-O-DMT-2'-O-MOE-T-CE
  • 2'-O-MOE-5-Me-U -CE Phosphoramidite
  • 2'-MOE-U CE Phosphoramidite
  • 5'-O-DMT-2'-O-MOE- 5-Me-Uridine -3’-Cyanoethyl Phosphoramidite
  • 2'-MOE Thymidine Amidite
  • 5-Me-DMT-2'-O-MOE-U-CE
  • DMT-2''O-MOE-rMeU Amidite，septum
  • 5-Methyl-2 '- Methoxyuridine
  • DMTr-2'-O-MOE-rT-3'-CE-Phosphoramidite
  • 2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
  • 5’-O-(4, 4’-Dimethoxytrityl)-5-methyl-2’-O-(2-methoxyethyl)uridine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-ODMT-2'-OMOE-5-methyluridine-3'-OCEPA
  • 2’-O-MOE-5MeU-3’-phospho ramidite
  • DMT-2'-O-MOE-T-CE-Phosphoramidite
  • 2'-MOE-U CE Phosphoramidite
  • 5'-O-DMT-2'-O-MOE-T-CE
  • 2'-O-MOE-5-Me-U-CE-Phosphoramidite
  • 5-Me-2'-O-MOE-5'-O-DMT-Me-U-CE-Phosphoramidite
  • 2'-O-MOE-5-Me-rU Phosphoramidite
  • [5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-5-methyluridin-3'-O-yl]-2-cyanoethyl-N,N'-diisopropylphosphoramidite
  • 5'-O-DMT-5-Methy-2'-O-(2-methoxyethyl)uridine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-O-MOE- 5-Me-Uridine -3’-Cyanoethyl Phosphoramidite
  • 2'-MOE Thymidine Amidite
  • 163878-63-5
  • C43H55N4O10P
  • Amidite