2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

Uses

Product Name: 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER
CAS No.: 1003845-08-6
Chemical Name: 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER
Synonyms: 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine;2-dioxaborolan-2-yl)pyriMidine;2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER;2-ChloropyriMidin-5-ylboronic acid pinacol ester;2-Chloropyrimidine-5-boronicacidpinacolester,98%;2-chloropyrimidine-5-borate frequency which ol ester;2-Chloropyrimidine-5-boronic acid pinacol ester, 95%,;2-(5-Chloro-2-pyrimidyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(2-Chloro-5-pyrimidinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;Pyrimidine, 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB62465526
Molecular Formula: C10H14BClN2O2
Formula Weight: 240.49
MOL File: 1003845-08-6.mol

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2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Property

Melting point:: 65.0 to 69.0 °C
Boiling point:: 369.1±15.0 °C(Predicted)
Density: 1.19±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Solid
pka: -1.68±0.22(Predicted)
color: White to Yellow to Orange

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3436
Product name: 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: C3436
Product name: 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $301
Updated: 2025/07/31

TRC

Product number: C428453
Product name: 2-Chloropyrimidine-5-boronicacidpinacolester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W006099
Product name: 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Purity: ≥97.0%
Packaging: 5g
Price: $68
Updated: 2021/12/16

AK Scientific

Product number: X1294
Product name: 2-Chloropyrimidine-5-boronicacidpinacolester
Packaging: 250mg
Price: $26
Updated: 2021/12/16

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2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production

Uses

Pinacol 2-chloropyrimidine-5-boronate is used to prepare indole derivatives, exhibiting broad pharmacological activity as a selective Pim kinase inhibitor. It is also used to prepare TGF-β1 inhibitors and activin A signal transducers. It is an important chemical product and a key pharmaceutical intermediate.

Synthesis

76-09-5

1003845-06-4

1003845-08-6

34). General procedure for the synthesis of 2-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidines: to a mixture of toluene (16 mL) and THF (4 mL) containing 5-bromo-2-chloropyrimidine (10 mmol, 1.93 g) and triisopropyl borate (12 mmol, 2.8 mL) at -78 °C, over a period of Hexane (1.58 M, 12 mmol, 7.6 mL) was added slowly and dropwise over 45 min. The reaction mixture was continued to be stirred at -78 °C for 1 hour. Subsequently, the mixture was slowly warmed to -20 °C and 1 M aqueous hydrochloric acid (20 mL) was added. After continued warming to room temperature, the precipitate was collected and washed with hexane to give a colorless powder (808 mg, 51% yield). A mixture of this powder (3.63 mmol, 575 mg), pinacol (3.81 mmol, 450 mg), and magnesium sulfate (18.15 mmol, 2.2 g) in toluene (10 mL) was stirred at room temperature for 15 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting solid was washed with water to afford the target product 2-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidine (875 mg, quantitative yield); ESI-MS m/z: 159 [M + 1 - pinacol], retention time 1.75 min (condition A).

References

[1] Patent: WO2008/9435, 2008, A1. Location in patent: Page/Page column 189-190
[2] Patent: US2009/118287, 2009, A1. Location in patent: Page/Page column 67-68

2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Suppliers

Americas 1 China 113 Europe 1 France 1 India 3 Japan 1 Switzerland 1 United Kingdom 2 United States 10 Global 133

Alfa Aesar

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Shanghai Jian Chao Chemical Technology Co., Ltd.

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View Lastest Price from 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-dioxaborolan-2-yl)pyriMidine 1003845-08-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 1003845-08-6
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-07

1003845-08-6, 2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTERRelated Search:

2,4,5-Trichloropyrimidine 2-CHLORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 2-FLUOROPHENYLBORONIC ACID, PINACOL ESTER 2-(4-BroMo-2,6-difluoro-phenyl)-4,4,5,5-tetraMethyl-[1,3,2]dioxaborolane 1-(3-Methoxypropyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1,2,3,6-tetrahydropyridine 2-(3-BroMo-2-fluoro-phenyl)-4,4,5,5-tetraMethyl-[1,3,2]dioxaborolane 1-Isopropyl-1H-pyrazole-5-boronic acid, pinacol ester

2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

2-dioxaborolan-2-yl)pyriMidine

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

2-ChloropyriMidin-5-ylboronic acid pinacol ester

2-(2-Chloro-5-pyrimidinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Pyrimidine, 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-Chloropyrimidine-5-boronicacidpinacolester,98%

2-(5-Chloro-2-pyrimidyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-Chloropyrimidine-5-boronic acid pinacol ester, 95%,

2-chloropyrimidine-5-borate frequency which ol ester

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine - [C15930]

1003845-08-6