8-BROMO-2H-ISOQUINOLIN-1-ONE
- Product Name
- 8-BROMO-2H-ISOQUINOLIN-1-ONE
- CAS No.
- 475994-60-6
- Chemical Name
- 8-BROMO-2H-ISOQUINOLIN-1-ONE
- Synonyms
- 8-Bromoisoquinolin-1-ol;8-Bromoisoquinolin-1(2H);8-Bromoisoquinolin-1(2H)-one;8-BROMO-2H-ISOQUINOLIN-1-ONE;8-Bromo-1(2H)-isoquinolinone;8-BroMo-2H-isoquinoline-1-one;8-Bromo-1-hydroxyisoquinoline;1(2H)-Isoquinolinone, 8-bromo-;8-bromo-1(2H)-isoquinolin-1-one
- CBNumber
- CB62466376
- Molecular Formula
- C9H6BrNO
- Formula Weight
- 224.05
- MOL File
- 475994-60-6.mol
8-BROMO-2H-ISOQUINOLIN-1-ONE Property
- Boiling point:
- 446.1±45.0 °C(Predicted)
- Density
- 1.620±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- pka
- 11.81±0.20(Predicted)
- form
- powder
- color
- Yellow
- InChI
- InChI=1S/C9H6BrNO/c10-7-3-1-2-6-4-5-11-9(12)8(6)7/h1-5H,(H,11,12)
- InChIKey
- NQMZAFRCYDJSEU-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2Br)C=CN1
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B688673
- Product name
- 8-Bromo-2H-isoquinolin-1-one
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H01-9-26
- Product name
- 8-Bromo-1-hydroxyisoquinoline
- Packaging
- 100mg
- Price
- $34
- Updated
- 2021/12/16
- Product number
- G14306
- Product name
- 8-Bromoisoquinolin-1-ol
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 4H01-9-26
- Product name
- 8-Bromo-1-hydroxyisoquinoline
- Packaging
- 500mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- G14306
- Product name
- 8-Bromoisoquinolin-1-ol
- Packaging
- 5g
- Price
- $160
- Updated
- 2021/12/16
8-BROMO-2H-ISOQUINOLIN-1-ONE Chemical Properties,Usage,Production
Synthesis
475994-58-2
475994-60-6
The general procedure for the synthesis of 8-bromoisoquinolin-1(2H)-one from 8-bromoisoquinoline 2-oxide was as follows: 8-bromoisoquinoline 2-oxide (630 mg, 2.8 mmol) was suspended in N,N-dimethylformamide (DMF, 10 mL), and treated with trifluoroacetic anhydride (4 mL). The reaction mixture was stirred overnight at room temperature until the solution was clarified. Subsequently, the reaction solution was concentrated under reduced pressure to remove the solvent. The residue was neutralized with dilute aqueous sodium carbonate and extracted several times with a 5% methanol/dichloromethane mixture. The organic phases were combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography, eluting with a gradient of 0-10% methanol in dichloromethane solution to give a white solid product (180 mg, 29% yield). Mass spectrometric analysis (positive ion electrospray mode) showed m/z 225 [M+H]+.
References
[1] Patent: WO2004/2992, 2004, A1. Location in patent: Page 76; 77
[2] Tetrahedron, 2002, vol. 58, # 29, p. 5761 - 5766
[3] Patent: WO2017/100591, 2017, A1. Location in patent: Paragraph 00226
8-BROMO-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-BROMO-2H-ISOQUINOLIN-1-ONE manufacturers
- Product
- 8-BROMO-2H-ISOQUINOLIN-1-ONE 475994-60-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07