GSK461364

ChemicalBook > CAS DataBase List > GSK461364

Product Name: GSK461364
CAS No.: 929095-18-1
Chemical Name: GSK461364
Synonyms: CS-553;GSK4613;GSK461364;GSK-461364;GSK-461364A;GSK461364 USP/EP/BP;GSK461364(GSK-461364);GSK-461364; GSK-461364A;PLK1 inhibitor GS461364;PLK1 inhibitor GSK461364
CBNumber: CB62473747
Molecular Formula: C27H28F3N5O2S
Formula Weight: 543.6
MOL File: 929095-18-1.mol

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GSK461364 Property

Melting point:: >150°C (dec.)
Boiling point:: 658.0±65.0 °C(Predicted)
Density: 1.39
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 15.16±0.50(Predicted)
form: Solid
color: Off-White to Light Beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18099
Product name: GSK461364
Purity: ≥95%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 18099
Product name: GSK461364
Purity: ≥95%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 18099
Product name: GSK461364
Purity: ≥95%
Packaging: 10mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 18099
Product name: GSK461364
Purity: ≥95%
Packaging: 25mg
Price: $493
Updated: 2024/03/01

TRC

Product number: G797705
Product name: GSK461364
Packaging: 2.5mg
Price: $50
Updated: 2021/12/16

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GSK461364 Chemical Properties,Usage,Production

Uses

GSK 461364 is a dose-dependant inhibitor of proliferating cancer cell lines as well as an apoptotic agent at higher dosage levels.

Definition

ChEBI: 5-[6-[(4-methyl-1-piperazinyl)methyl]-1-benzimidazolyl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide is a member of (trifluoromethyl)benzenes.

Biological Activity

gsk461364 is a potent and reversible atp competitive plk1 inhibitor. polo-like kinases (plk) are a family of serine threonine kinases that are critical regulators of dna damage response and cell cycle progression.

in vitro

gsk461364 showed at least 390-fold greater selectivity for plk1 than for plk2 and plk3 and 1,000-fold greater than for 48 other kinases. the drug showed antiproliferative activity against multiple (>120) tumor cell lines and potently inhibited the proliferation of greater than 83% and 91% of these cell lines [1].

in vivo

intraperitoneal administration of gsk461364 caused regression or tumor growth delay in different xenograft models. in vivo suppression of plk1 by using gsk461364 resulted in mitotic arrest with aberrant mitotic figures consisting of monopolar or collapsed mitotic spindles [1].

target

PLK1

References

[1] olmos d, barker d, sharma r, brunetto at, yap ta, taegtmeyer ab, barriuso j, medani h, degenhardt yy, allred aj, smith da, murray sc, lampkin ta, dar mm, wilson r, de bono js, blagden sp. phase i study of gsk461364, a specific and competitive polo-like kinase 1 inhibitor, in patients with advanced solid malignancies. clin cancer res. 2011 may 15;17(10):3420-30.

GSK461364 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GSK461364 manufacturers

Career Henan Chemical Co

Product: GSK-461364 929095-18-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

929095-18-1, GSK461364Related Search:

RET Kinase inhibitor 1 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide GSK484 GSK583 GSK369796 GSK547 GSK-467 GSK481 GSK-3326595 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide Bortezomib MLN0905 PD 0325901 BI 2536 Ibrutinib Volasertib (BI 6727)

(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

GSK-461364A

GSK461364(GSK-461364)

5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]

5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phen

GSK461364

GSK-461364

GSK4613

GSK461364, 98%, a potent Polo-like kinase 1 (PLK1) inhibitor

5-[6-[(4-methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-Thiophenecarboxamide

GSK-461364; GSK-461364A

PLK1 inhibitor GS461364

CS-553

2-Thiophenecarboxamide, 5-[6-[(4-methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-

GSK461364 USP/EP/BP

PLK1 inhibitor GSK461364

5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide

929095-18-1

C27H28F3N5O2S

Inhibitors

APIs