ChemicalBook > CAS DataBase List > Lomitapide

Lomitapide

Product Name
Lomitapide
CAS No.
182431-12-5
Chemical Name
Lomitapide
Synonyms
AEGR 733;BMS 201038;LoMitapide;BMS 201238;BMS 201038-01;AEGR733, BMS201038;AEGR-733(Lomitapide);CB62485047,loMitapide;Lomitapide (10mM in DMSO);AEGR-733(Lomitapide)free base
CBNumber
CB62485047
Molecular Formula
C39H37F6N3O2
Formula Weight
693.72
MOL File
182431-12-5.mol
More
Less

Lomitapide Property

Melting point:
142°C(lit.)
Boiling point:
778.2±60.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
12.66±0.20(Predicted)
form 
powder
color 
white to beige
More
Less

Safety

HS Code 
2933.39.4100
Hazardous Substances Data
182431-12-5(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1385
Product name
Lomitapide
Purity
≥98% (HPLC)
Packaging
5MG
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1385
Product name
Lomitapide
Purity
≥98% (HPLC)
Packaging
25MG
Price
$693
Updated
2024/03/01
TCI Chemical
Product number
L0298
Product name
Lomitapide
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$112
Updated
2024/03/01
TCI Chemical
Product number
L0298
Product name
Lomitapide
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$302
Updated
2024/03/01
Cayman Chemical
Product number
10009610
Product name
Lomitapide
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
More
Less

Lomitapide Chemical Properties,Usage,Production

Description

Lomitapide was approved by the US FDA in December 2012 for the treatment of patients with familial hypercholesteremia (referred to as HoFH) in conjunction with a low-fat diet andother lipid-lowering treatments. Lomitapide was discovered from a high-through put screen that identified several structurally distinct MTP inhibitors. Combination of key structural features from two structurally distinct HTS hits provided potent MTP inhibitors. Parallel analog synthesis led to lomitapide as an optimized structure. Lomitapide was synthesized via alkylation of 9-fluorenylcarboxylic acid with 1,4-dibromobutane which, after trifluoroethylamide formation, provided a bromide intermediate that was displaced by Boc-4-aminopiperidine. Introduction of the 4'-trifluoromethylbiphenylcarboxamide gave lomitapide, which was found to inhibit MTP with an IC50 of 0.5 nM and to exhibit good cholesterol-lowering efficacy in Sprague–Dawley rats (intravenous and oral ED50～0.2 mg/kg).

Originator

Bristol-Myers Squibb (United States)

Uses

Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.

Definition

ChEBI: Lomitapide is a member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. It has a role as an anticholesteremic drug and a MTP inhibitor. It is a member of piperidines, a member of fluorenes, a member of benzamides and a member of (trifluoromethyl)benzenes. It is a conjugate base of a lomitapide(1+).

brand name

Juxtapid

Biochem/physiol Actions

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia.

Lomitapide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Lomitapide Suppliers

Americas 1 China 112 Europe 1 France 1 India 5 Japan 1 United States 14 Global 135
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
More
Less

View Lastest Price from Lomitapide manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Lomitapide 182431-12-5
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-19
Career Henan Chemica Co
Product
AEGR-733 182431-12-5
Price
US $1.00/g
Min. Order
1g
Purity
MIn98% HPLC/LC
Supply Ability
100KGS
Release date
2020-10-28

182431-12-5, LomitapideRelated Search:

Ethyl nonafluorobutyl ether N-Ethylacetamide 2-Aminoethyl(ethyl)amine N-Ethyl-3-methylaniline N-ethyl-pyrrolidone 2-(Perfluorohexyl)ethyl methacrylate AS-252424 Gefitinib Ezetimibe Nilotinib Amonafide Apremilast

  • AEGR-733; BMS-201038; AEGR733; BMS201038; AEGR 733; BMS 201038;
  • AEGR-733(Lomitapide)
  • N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide
  • N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide
  • AEGR 733
  • BMS 201038
  • BMS 201038-01
  • BMS 201238
  • LoMitapide
  • N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoroMethyl)biphenyl-2-ylcarboxaMido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxaMide
  • CB62485047,loMitapide
  • AEGR-733(Lomitapide)free base
  • AEGR733, BMS201038
  • 9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-
  • N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide
  • Lomitapide (10mM in DMSO)
  • N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-...
  • Lomitapide D8Q: What is Lomitapide D8 Q: What is the CAS Number of Lomitapide D8 Q: What is the storage condition of Lomitapide D8
  • N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide
  • N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
  • 182431-12-5
  • C39H37F6N3O2
  • Inhibitors