Lomitapide

Product Name: Lomitapide
CAS No.: 182431-12-5
Chemical Name: Lomitapide
Synonyms: AEGR 733;BMS 201038;LoMitapide;BMS 201238;BMS 201038-01;AEGR733, BMS201038;AEGR-733(Lomitapide);CB62485047,loMitapide;Lomitapide (10mM in DMSO);AEGR-733(Lomitapide)free base
CBNumber: CB62485047
Molecular Formula: C39H37F6N3O2
Formula Weight: 693.72
MOL File: 182431-12-5.mol

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Lomitapide Property

Melting point:: 142°C(lit.)
Boiling point:: 778.2±60.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.66±0.20(Predicted)
form: powder
color: white to beige

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Safety

HS Code: 2933.39.4100
Hazardous Substances Data: 182431-12-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1385
Product name: Lomitapide
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $173
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1385
Product name: Lomitapide
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $693
Updated: 2024/03/01

TCI Chemical

Product number: L0298
Product name: Lomitapide
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $112
Updated: 2024/03/01

TCI Chemical

Product number: L0298
Product name: Lomitapide
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 10009610
Product name: Lomitapide
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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Lomitapide Chemical Properties,Usage,Production

Description

Lomitapide was approved by the US FDA in December 2012 for the treatment of patients with familial hypercholesteremia (referred to as HoFH) in conjunction with a low-fat diet andother lipid-lowering treatments. Lomitapide was discovered from a high-through put screen that identified several structurally distinct MTP inhibitors. Combination of key structural features from two structurally distinct HTS hits provided potent MTP inhibitors. Parallel analog synthesis led to lomitapide as an optimized structure. Lomitapide was synthesized via alkylation of 9-fluorenylcarboxylic acid with 1,4-dibromobutane which, after trifluoroethylamide formation, provided a bromide intermediate that was displaced by Boc-4-aminopiperidine. Introduction of the 4'-trifluoromethylbiphenylcarboxamide gave lomitapide, which was found to inhibit MTP with an IC₅₀ of 0.5 nM and to exhibit good cholesterol-lowering efficacy in Sprague–Dawley rats (intravenous and oral ED₅₀～0.2 mg/kg).

Originator

Bristol-Myers Squibb (United States)

Uses

Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.

Definition

ChEBI: Lomitapide is a member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. It has a role as an anticholesteremic drug and a MTP inhibitor. It is a member of piperidines, a member of fluorenes, a member of benzamides and a member of (trifluoromethyl)benzenes. It is a conjugate base of a lomitapide(1+).

brand name

Juxtapid

Biochem/physiol Actions

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia.

Lomitapide Preparation Products And Raw materials

Raw materials

Preparation Products

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Lomitapide Suppliers

Americas 1 China 112 Europe 1 France 1 India 5 Japan 1 United States 14 Global 135

Alsachim SAS

Tel: --
Fax: --
Email: sales@alsachim.com
Country: France
ProdList: 424
Advantage: 0

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View Lastest Price from Lomitapide manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Lomitapide 182431-12-5
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-19

Career Henan Chemica Co

Product: AEGR-733 182431-12-5
Price: US $1.00/g
Min. Order: 1g
Purity: MIn98% HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-28

182431-12-5, LomitapideRelated Search:

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AEGR-733; BMS-201038; AEGR733; BMS201038; AEGR 733; BMS 201038;

AEGR-733(Lomitapide)

N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide

N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide

AEGR 733

BMS 201038

BMS 201038-01

BMS 201238

LoMitapide

N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoroMethyl)biphenyl-2-ylcarboxaMido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxaMide

CB62485047,loMitapide

AEGR-733(Lomitapide)free base

AEGR733, BMS201038

9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-

N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide

Lomitapide (10mM in DMSO)

N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-...

Lomitapide D8Q: What is Lomitapide D8 Q: What is the CAS Number of Lomitapide D8 Q: What is the storage condition of Lomitapide D8

N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide

N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide

182431-12-5

C39H37F6N3O2

Inhibitors