ChemicalBook > CAS DataBase List > (S)-Ketorolac

(S)-Ketorolac

Product Name: (S)-Ketorolac
CAS No.: 66635-92-5
Chemical Name: (S)-Ketorolac
Synonyms: Ketorolac S-IsoMer;(S)-Ketorolac ISO 9001：2015 REACH;Ketorolac impurity 2/Ketorolac S-Isomer;Phosphorousacid,tris(1,5-dimethylethyl)ester;1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-
CBNumber: CB62485724
Molecular Formula: C15H13NO3
Formula Weight: 255.27
MOL File: 66635-92-5.mol

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(S)-Ketorolac Property

Melting point:: 160-167?C
Boiling point:: 493.2±40.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform: Slightly; Ethanol: >1mg/ml; Methanol: Slightly
form: A crystalline solid
pka: 4.29±0.20(Predicted)
color: White to off-white
optical activity: [α]/D -165 to -185°, c =0.5 in methanol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3299
Product name: S-Ketorolac
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $115.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3299
Product name: S-Ketorolac
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $495
Updated: 2025/07/31

Cayman Chemical

Product number: 11348
Product name: (S)-Ketorolac
Purity: ≥98%
Packaging: 1mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 11348
Product name: (S)-Ketorolac
Purity: ≥98%
Packaging: 5mg
Price: $414
Updated: 2024/03/01

TRC

Product number: K235605
Product name: (S)-Ketorolac
Packaging: 2mg
Price: $155
Updated: 2021/12/16

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(S)-Ketorolac Chemical Properties,Usage,Production

Description

(S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC₅₀s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). (S)-Ketorolac is approximately twice as potent as the racemic mixture and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac. Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.

Chemical Properties

Off-White Solid

Uses

The R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Uses

(S)-Ketorolac is the S-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Definition

ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known s mply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.

References

[1] DR. DEAN A. HANDLEY PHD. Preclinical Enantioselective Pharmacology of (R)- and (S)- Ketorolac[J]. The Journal of Clinical Pharmacology, 2013, 38 2S: 25S-35S. DOI: 10.1002/j.1552-4604.1998.tb04414.x
[2] ANGEL GUSMAN. Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac[J]. Journal of Medicinal Chemistry, 1986, 29 4: 589-591. DOI: 10.1021/jm00154a027
[3] S K DUBEY R N S A Anand. Enantioselective Tissue Distribution of Ketorolac and its Enantiomers in Rats.[J]. Drug Research, 2015, 65 8: 428-431. DOI: 10.1055/s-0034-1389913
[4] DDS S M G, MPH Jaime S B D, MS Janet R R, et al. Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: Replicate clinical trials in a tissue injury model[J]. Clinical Pharmacology & Therapeutics, 2002, 72 2: 175-183. DOI: 10.1067/mcp.2002.126501

(S)-Ketorolac Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-Ketorolac manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (S)-Ketorolac 66635-92-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

66635-92-5, (S)-KetorolacRelated Search:

Ketorolac Impurity 48 rac Ketorolac 6-Benzoyl IsoMer 5-Benzoyl-2,3-Dihydro-Lh-Pyrrolizme-L,L-DicarboxyiicAcid,KetoralacTromethamine 2,2'-BIPYRROL Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide) 1-Descarboxy Ketorolac Ketorolac EP IMpurity G Ketorolac Impurity 31 1-Keto Ketorolac (R)-(+)-Ketorolac Ketorolac Impurity 24 (5-chloro-1H-pyrrol-2-yl)-phenylmethanone 4-HYDROXY KETOROLAC Ketorolac Impurity 43 Ethyl 2-(1H-pyrrol-2-yl)acetate 3-BENZOYLPYRROLE Ketorolac Related Compound B (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol) Ketorolac tromethamine

Ketorolac S-IsoMer

Ketorolac impurity 2/Ketorolac S-Isomer

1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-

(S)-Ketorolac ISO 9001：2015 REACH

Phosphorousacid,tris(1,5-dimethylethyl)ester

66635-92-5

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