ChemicalBook > CAS DataBase List > (S)-Ketorolac

(S)-Ketorolac

Product Name
(S)-Ketorolac
CAS No.
66635-92-5
Chemical Name
(S)-Ketorolac
Synonyms
Ketorolac S-IsoMer;(S)-Ketorolac ISO 9001：2015 REACH;Ketorolac impurity 2/Ketorolac S-Isomer;Phosphorousacid,tris(1,5-dimethylethyl)ester;1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-
CBNumber
CB62485724
Molecular Formula
C15H13NO3
Formula Weight
255.27
MOL File
66635-92-5.mol
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(S)-Ketorolac Property

Melting point:
160-167?C
Boiling point:
493.2±40.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform: Slightly; Ethanol: >1mg/ml; Methanol: Slightly
form 
A crystalline solid
pka
4.29±0.20(Predicted)
color 
White to off-white
optical activity
[α]/D -165 to -185°, c =0.5 in methanol
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3299
Product name
S-Ketorolac
Purity
≥98% (HPLC)
Packaging
5MG
Price
$116
Updated
2023/06/20
Sigma-Aldrich
Product number
SML3299
Product name
S-Ketorolac
Purity
≥98% (HPLC)
Packaging
25MG
Price
$469
Updated
2023/06/20
Cayman Chemical
Product number
11348
Product name
(S)-Ketorolac
Purity
≥98%
Packaging
1mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
11348
Product name
(S)-Ketorolac
Purity
≥98%
Packaging
5mg
Price
$414
Updated
2024/03/01
TRC
Product number
K235605
Product name
(S)-Ketorolac
Packaging
2mg
Price
$155
Updated
2021/12/16
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(S)-Ketorolac Chemical Properties,Usage,Production

Description

(S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). (S)-Ketorolac is approximately twice as potent as the racemic mixture and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac. Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.

Chemical Properties

Off-White Solid

Uses

The R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Uses

(S)-Ketorolac is the S-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Definition

ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known s mply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.

(S)-Ketorolac Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-Ketorolac manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(S)-Ketorolac 66635-92-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25

66635-92-5, (S)-KetorolacRelated Search:

Ketorolac Impurity 48 rac Ketorolac 6-Benzoyl IsoMer 5-Benzoyl-2,3-Dihydro-Lh-Pyrrolizme-L,L-DicarboxyiicAcid,KetoralacTromethamine 2,2'-BIPYRROL Ketorolac Related Compound A (20 mg) (5-benzoyl-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2,3-dihydro-1H-pyrrolizine-1-carboxamide) 1-Descarboxy Ketorolac Ketorolac EP IMpurity G Ketorolac Impurity 31 1-Keto Ketorolac (R)-(+)-Ketorolac Ketorolac Impurity 24 (5-chloro-1H-pyrrol-2-yl)-phenylmethanone 4-HYDROXY KETOROLAC Ketorolac Impurity 43 Ethyl 2-(1H-pyrrol-2-yl)acetate 3-BENZOYLPYRROLE Ketorolac Related Compound B (20 mg) (5-benzoyl-2,3-dihydro-1H-pyrrolizin-1-ol) Ketorolac tromethamine

  • Ketorolac S-IsoMer
  • Ketorolac impurity 2/Ketorolac S-Isomer
  • 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-
  • (S)-Ketorolac ISO 9001：2015 REACH
  • Phosphorousacid,tris(1,5-dimethylethyl)ester
  • 66635-92-5
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals