Anacetrapib
- Product Name
- Anacetrapib
- CAS No.
- 875446-37-0
- Chemical Name
- Anacetrapib
- Synonyms
- CS-66;Mk0859;Mk-0859;Anacetrapib;Anacetripib;Timapiprant;Unii-p7T269pr6s;Anacetrapib 13C6;Anacetrapib, >=99%;Anacetrapib(MK0859)
- CBNumber
- CB62487713
- Molecular Formula
- C30H25F10NO3
- Formula Weight
- 637.51
- MOL File
- 875446-37-0.mol
Anacetrapib Property
- Boiling point:
- 555.3±50.0 °C(Predicted)
- Density
- 1.345
- storage temp.
- Store at -20°C
- solubility
- ≥31.9 mg/mL in DMSO; insoluble in H2O; ≥86.6 mg/mL in EtOH
- form
- solid
- pka
- -2.30±0.60(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21558
- Product name
- Anacetrapib
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 21558
- Product name
- Anacetrapib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $268
- Updated
- 2024/03/01
- Product number
- 21558
- Product name
- Anacetrapib
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $435
- Updated
- 2024/03/01
- Product number
- 21558
- Product name
- Anacetrapib
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1002
- Updated
- 2024/03/01
- Product number
- A637200
- Product name
- Anacetrapib
- Packaging
- 25mg
- Price
- $6720
- Updated
- 2021/12/16
Anacetrapib Chemical Properties,Usage,Production
Uses
An orally active and potent cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis, in particular dyslipidemia.
Biological Activity
anacetrapib, also known as mk-0859, is a potent and selective inhibitor of cholesteryl ester transfer protein (cetp) that exhibits strong inhibition against cetp-mediated transfer of cholesteryl esters and triglycerides with values of inhibition constant ic50 of 16 nm and 29 nm respectively. anacetrapib is mainly metabolized by cyp3a4 through o-demethylation, hydroxylation on the biphenyl moiety and hydroxylation on the isopropyl side chain resulting in three oxidative metabolites m1, m2 and m3 respectively. anacetrapib is being investigated for the treatment of primary hypercholesterolemia and mixed hyperlipidemia due to its impressive effects to lower low-density lipoprotein (ldl) cholesterol levels and increase high-density lipoprotein (hdl) cholesterol levels without any associated major adverse events.tan ey, hartmann g, chen q, pereira a, bradley s, doss g, zhang as, ho jz, braun mp, dean dc, tang w, kumar s. pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys. drug metab dispos. 2010;38(3):459-473.kumar s, tan ey, hartmann g, biddle z, bergman aj, dru j, ho jz, jones an, staskiewicz sj, braun mp, karanam b, dean dc, gendrano in, graves mw, wagner ja, krishna r. metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans. drug metab dispos. 2010;38(3):474-483
Enzyme inhibitor
This cholesteryl ester transfer protein (or CETP) inhibitor (FW = 637.51 g/mol; CAS 875446-37-0), also known by the code name MK-0859, reduces plasma cholesterol concentrations, thereby increasing serum highdensity lipoprotein levels and preventing cardiovascular disease associated with hypercholesteremia. X-ray crystal studies suggest that CETP is a crescent-shaped protein with a 6-nm hydrophobic tunnel traversing its core Both of the tunnel’s two entrances face the protein’s concave surface, which most likely is the interaction platform for binding HDL particles and engaging its lipoprotein constituents. CETP mediates the reciprocal transfer of neutral lipids (e.g., cholesteryl esters and triglycerides) and phospholipids between different lipoprotein fractions in blood plasma. Anacetrapib is unlike many CETP inhibitors, which increase systolic blood pressure. Anacetrapib also exhibits a low-to-moderate degree of absorption after oral dosing and majority of the absorbed dose is eliminated via oxidation to a series of hydroxylated metabolites that undergo conjugation with glucuronate before excretion into bile. Unlike torcetrapib, another CETP inhibitor, anacetrapib does not elevate blood pressure, alter electrolytes, or cause any significant side effects.
target
rhCETP
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View Lastest Price from Anacetrapib manufacturers
- Product
- Anacetrapib 875446-37-0
- Price
- US $70.00-700.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-13
- Product
- Anacetrapib 875446-37-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-31
- Product
- Anacetrapib 875446-37-0
- Price
- US $50.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 5 tons
- Release date
- 2023-10-25