3,5-Dichloropyrazine-2-carbonitrile
Uses- Product Name
- 3,5-Dichloropyrazine-2-carbonitrile
- CAS No.
- 313339-92-3
- Chemical Name
- 3,5-Dichloropyrazine-2-carbonitrile
- Synonyms
- 3,5-Dichloropyrazinecarbonitrile;3,5-Dichloro-2-pyrazinecarbonitrile;5-dichloropyrazine-2-carbonitrile;1,3-Propanediol,1-(5-piperidinyl)-;3,5-Dichloropyrazine-2-carbonitrile;2-Pyrazinecarbonitrile, 3,5-dichloro-;3,5-Dichloropyrazine-2-carbonitrile ISO 9001：2015 REACH;2-Cyano-3,5-dichloropyrazine, 2-Cyano-3,5-dichloro-1,4-diazin;2-Cyano-3,5-dichloropyrazine, 2-Cyano-3,5-dichloro-1,4-diazine
- CBNumber
- CB62489661
- Molecular Formula
- C5HCl2N3
- Formula Weight
- 173.99
- MOL File
- 313339-92-3.mol
3,5-Dichloropyrazine-2-carbonitrile Property
- Boiling point:
- 277℃
- Density
- 1.60
- Flash point:
- 121℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -8.85±0.10(Predicted)
- form
- solid
- color
- White
- InChI
- InChI=1S/C5HCl2N3/c6-4-2-9-3(1-8)5(7)10-4/h2H
- InChIKey
- SDTCGHLDTSGIRR-UHFFFAOYSA-N
- SMILES
- C1(C#N)=NC=C(Cl)N=C1Cl
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D437140
- Product name
- 3,5-Dichloropyrazine-2-carbonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 073768
- Product name
- 3,5-Dichloropyrazine-2-carbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- D13904
- Product name
- 3,5-Dichloropyrazine-2-carbonitrile
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- FD138213
- Product name
- 3,5-Dichloropyrazine-2-carbonitrile
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD138213
- Product name
- 3,5-Dichloropyrazine-2-carbonitrile
- Packaging
- 2g
- Price
- $120
- Updated
- 2021/12/16
3,5-Dichloropyrazine-2-carbonitrile Chemical Properties,Usage,Production
Uses
3,5-Dichloropyrazine-2-carboxynitrile is a chemical intermediate.
Synthesis
312736-50-8
313339-92-3
General procedure for the synthesis of 3,5-dichloropyrazine-2-carbonitrile from 3,5-dichloropyrazine-2-carboxamide: To a solution of acetonitrile (100 mL) of 3,5-dichloropyrazine-2-carboxamide (5.0 g, 13.3 mmol) obtained in Preparation Example 13.1 was added phosphorous triclorethylene (6.76 mL, 72.3 mmol), and the reaction was stirred for 4 hr at 80 °C. Upon completion of the reaction, the reaction mixture was diluted with water and subsequently extracted with ethyl acetate and the organic layer was washed with saturated saline. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: 20% n-hexane/ethyl acetate) to afford 3,5-dichloropyrazine-2-carbonitrile (2.94 g, 65% yield) as a solid.
References
[1] Organic Letters, 2013, vol. 15, # 9, p. 2156 - 2159
[2] Patent: WO2016/6975, 2016, A2. Location in patent: Paragraph 461-463
[3] Patent: KR2016/7347, 2016, A. Location in patent: Paragraph 0359; 0363; 0364; 0365
[4] Patent: WO2018/22992, 2018, A1. Location in patent: Paragraph 0725; 0726
[5] Patent: US2018/72743, 2018, A1. Location in patent: Paragraph 1330-1331
3,5-Dichloropyrazine-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Dichloropyrazine-2-carbonitrile manufacturers
- Product
- 3,5-Dichloropyrazine-2-carbonitrile 313339-92-3
- Price
- US $10.00-3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-26
- Product
- 3,5-Dichloropyrazine-2-carbonitrile 313339-92-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-11