(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

ChemicalBook > CAS DataBase List > (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

Product Name: (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
CAS No.: 199433-58-4
Chemical Name: (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
Synonyms: Y 33075;Y 33075,Y33075;Y 39983;Y39983;Y33075;Y 39983;(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide;4-[(1R)-1-Aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide;Benzamide, 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-;(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide ISO 9001：2015 REACH
CBNumber: CB62510121
Molecular Formula: C16H16N4O
Formula Weight: 280.32
MOL File: 199433-58-4.mol

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(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Property

Boiling point:: 588.8±50.0 °C(Predicted)
Density: 1.32
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (178.37 mM; Need ultrasonic and warming)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 11.13±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0097
Product name: Y-33075
Purity: 99.19%
Packaging: 10mg
Price: $330
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014195
Product name: Y-33075
Purity: 95.00%
Packaging: 10MG
Price: $517.65
Updated: 2021/12/16

ChemScene

Product number: CS-0097
Product name: Y-33075
Purity: 99.19%
Packaging: 50mg
Price: $1188
Updated: 2021/12/16

Crysdot

Product number: CD31002772
Product name: Y-33075
Purity: 98+%
Packaging: 50mg
Price: $644
Updated: 2021/12/16

CSNpharm

Product number: CSN18082
Product name: Y-33075
Packaging: 25mg
Price: $500
Updated: 2021/12/16

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(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Chemical Properties,Usage,Production

Definition

ChEBI: 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide is a pyrrolopyridine.

Biological Activity

Y-33075 is a potent ROCK inhibitor derived from Y-27632, but more active with IC50 value of 3.6 nM.

in vitro

Y-33075 (Y-39983) is a potent ROCK inhibitor, with an IC ₅₀ of 3.6 nM. It also inhibits PKC and CaMKII more potently than Y-27632, and the IC ₅₀ s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively, whereas the IC ₅₀ s of Y-27632 and Y- 33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC ₅₀ s of Y-27632 and Y-33075 for PKC are 82 and 117 times those for ROCK, respectively, whereas the IC ₅₀ s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively. Y-33075 (Y-39983, 10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983. It (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca ²⁺ -free solutions. Y-33075 ( 10 μM) shows no effect on the [Ca ²⁺ ]i increase with the high-potassium (high-K) solution.

target

ROCK

3.6 nM (IC ₅₀ )

PKC

420 nM (IC ₅₀ )

CaMKII

810 nM (IC ₅₀ )

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide 199433-58-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

199433-58-4, (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamideRelated Search:

PRND N-Ethylaniline Y27632 (hydrochloride) N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320 (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Y-27632 DIHYDROCHLORIDE

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

Y 33075

Y33075;Y 39983

Y 39983;Y39983

Benzamide, 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-

4-[(1R)-1-Aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide ISO 9001：2015 REACH

Y 33075,Y33075

199433-58-4