ChemicalBook > CAS DataBase List > BIIB-021

BIIB-021

Product Name
BIIB-021
CAS No.
848695-25-0
Chemical Name
BIIB-021
Synonyms
CS-479;CNF2024;BIIB-021;CNF-2024EC102;BIIB021/CNF2024;BIIB 021, ≥98%;BIIB021 BIIB-021;BIIB-021 USP/EP/BP;CNF 2024 - BIIB 021;BIIB021(CNF2024)BIIB021
CBNumber
CB62516264
Molecular Formula
C14H15ClN6O
Formula Weight
318.76
MOL File
848695-25-0.mol
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BIIB-021 Property

Melting point:
192-193℃
Boiling point:
588.5±60.0 °C(Predicted)
Density 
1.50
storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
pka
6.07±0.40(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.
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Safety

HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18269
Product name
BIIB021
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
18269
Product name
BIIB021
Purity
≥98%
Packaging
5mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
18269
Product name
BIIB021
Purity
≥98%
Packaging
10mg
Price
$88
Updated
2024/03/01
Cayman Chemical
Product number
18269
Product name
BIIB021
Purity
≥98%
Packaging
25mg
Price
$156
Updated
2024/03/01
Tocris
Product number
4608
Product name
BIIB021
Purity
≥98%(HPLC)
Packaging
10
Price
$219
Updated
2021/12/16
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BIIB-021 Chemical Properties,Usage,Production

Description

BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation).1 It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (IC50 = 100 nM for each).? BIIB021 has shown efficacy as a therapeutic in multiple cancer models.2-5

Uses

BIIB 021 an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Studies show that BIIB 021 adminisitration led to degradation of Hsp90 client proteins measured in tumor tissue and resulted in the inhibition of tumor growth in several human tumor xenograft models.

Definition

ChEBI: A member of the class of 2-aminopurines that is 2-aminopurine which is substituted by a chlorine at position 6 and by a (4-methoxy-3,5-dimethylpyridin-2-yl)methyl group at position 9.

References

Kasibhatla et al. (2007), Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity; J. Med. Chem. 50 2767 Lundgren et al. (2009), BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90; Mol. Cancer Ther. 8 921 Boll et al. (2009), Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin’s lymphoma cells for natural killer cell-mediated cytotoxicity; Clin. Cancer Res. 15 5108 Zhang et al. (2010), BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance; Int. J. Cancer 126 1226 Wang et al. (2014), BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation; Biochem. Biophys. Res. Commun. 452 945

BIIB-021 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIIB-021 Suppliers

Canada 1 China 107 India 3 Japan 1 United Kingdom 2 United States 19 Global 133
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View Lastest Price from BIIB-021 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
BIIB-021 848695-25-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

848695-25-0, BIIB-021Related Search:

NOTUMib-1 AZ20 BI 2536 Imiquimod PU-H71 Onalespib PD 0332991 HCl 17-AAG Ganetespib Olaparib

  • CNF2024
  • 9-[2-(2,2-diMethyl-propylaMino)ethyl]-8-(2-iodo-5-Methoxy-phenylsulfanyl)-9H-purin-6-ylaMine
  • CNF-2024EC102
  • 9H-Purin-2-aMine, 6-chloro-9-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]-
  • 6-chloro-9-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)-9H-purin-2-aMine
  • BIIB-021
  • BIIB021/CNF2024
  • 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
  • 6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]PURIN-2-AMINE
  • 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine BIIB 021
  • BIIB 021 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
  • BIIB021(CNF2024)BIIB021
  • BIIB 021 (This product is only available in Japan.)
  • BIIB021;BIIB-021; BIIB 021
  • CNF 2024 - BIIB 021
  • CNF2024; BIIB-021; BIIB 021; CNF 2024; CNF-2024
  • CS-479
  • BIIB-021 USP/EP/BP
  • BIIB 021, ≥98%
  • BIIB021 BIIB-021
  • 848695-25-0
  • C14H15ClN6O
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Antineoplastic
  • Inhibitor