ChemicalBook > CAS DataBase List > ARRY-380

ARRY-380

Product Name
ARRY-380
CAS No.
937265-83-3
Chemical Name
ARRY-380
Synonyms
CS-523;Arry-830;ARRY-380;ARRY-380-d3;Arry-380, >=98%;HER2-Inhibitor-1;ARRY380; ARRY 380;ARRY-380 (analog );ARRY-380 USP/EP/BP;ARRY-380;ARRY380; ARRY 380
CBNumber
CB62554080
Molecular Formula
C29H27N7O4S
Formula Weight
569.63
MOL File
937265-83-3.mol
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ARRY-380 Property

Density 
1.43
storage temp. 
Store at -20°C
solubility 
≥28.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
6.34±0.19(Predicted)
color 
Light brown to brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24186
Product name
Arry-380 analog
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24186
Product name
Arry-380 analog
Purity
≥98%
Packaging
5mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
24186
Product name
Arry-380 analog
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
24186
Product name
Arry-380 analog
Purity
≥98%
Packaging
25mg
Price
$305
Updated
2024/03/01
TRC
Product number
A774000
Product name
6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine
Packaging
1mg
Price
$70
Updated
2021/12/16
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ARRY-380 Chemical Properties,Usage,Production

Description

Arry-380 analog was designed as an inhibitor of EGFR (ErbB1).

Uses

ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM.

Uses

Labelled ARRY-380. ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2.

target

p95-HER2

References

[1] s. l. moulder, v. borges, s. k. l. chia, t. baetz, e. barrett, j. garrus, k. guthrie, c. kass, e. laird, j. lyssikatos, f. marmsater, e. wallace. arry-380, a selective her2 inhibitor: from drug design to clinical evaluation. poster of aacr-nci-eortc, nov 12-16, 2011, san francisco, ca.
[2] victoria dinkel, deborah anderson, shannon winski, jim winkler, kevin koch and patrice lee. arry-380, a potent, small molecule inhibitor of erbb2, increases survival in intracranial erbb2+ xenograft models in mice. poster available at www.arraybiopharma.com
[3] s. chia, t. baetz, s. d'aloisio, g. fernetich, b. freeman, e. barrett, c. kass, j. kang, b. sajan, s. moulder, and j. garrus. a phase 1 study to assess the safety, tolerability and pharmacokinetics of arry-380 – an oral inhibitor of her2. cancer res 2009;69(24 suppl):abstract nr 5111.

ARRY-380 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARRY-380 Suppliers

Canada 1 China 72 United States 14 Global 87
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from ARRY-380 manufacturers

Career Henan Chemica Co
Product
ARRY-380 937265-83-3
Price
US $1.00/g
Min. Order
1g
Purity
Min98%
Supply Ability
100kgs
Release date
2020-10-27

937265-83-3, ARRY-380Related Search:

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  • ARRY-380 (analog )
  • Arry-830
  • ARRY-380;ARRY380; ARRY 380
  • 6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]
  • Arry-380, >=98%
  • ARRY-380
  • 6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine
  • HER2-Inhibitor-1
  • 6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine ARRY 380
  • ARRY-380-d3
  • N-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-Methylphenyl)-6-(5-(((2-(Methylsulfonyl)ethyl)aMino)Methyl)furan-2-yl)quinazolin-4-aMine
  • 6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazolin-4-amine
  • ARRY380; ARRY 380
  • CS-523
  • 4-Quinazolinamine, 6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-
  • ARRY-380 USP/EP/BP
  • 937265-83-3
  • C29H27N7O4S
  • Inhibitors
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds