ARRY-380
- Product Name
- ARRY-380
- CAS No.
- 937265-83-3
- Chemical Name
- ARRY-380
- Synonyms
- CS-523;Arry-830;ARRY-380;ARRY-380-d3;Arry-380, >=98%;HER2-Inhibitor-1;ARRY380; ARRY 380;ARRY-380 (analog );ARRY-380 USP/EP/BP;ARRY-380;ARRY380; ARRY 380
- CBNumber
- CB62554080
- Molecular Formula
- C29H27N7O4S
- Formula Weight
- 569.63
- MOL File
- 937265-83-3.mol
ARRY-380 Property
- Density
- 1.43
- storage temp.
- Store at -20°C
- solubility
- ≥28.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- solid
- pka
- 6.34±0.19(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 24186
- Product name
- Arry-380 analog
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 24186
- Product name
- Arry-380 analog
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 24186
- Product name
- Arry-380 analog
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 24186
- Product name
- Arry-380 analog
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $305
- Updated
- 2024/03/01
- Product number
- A774000
- Product name
- 6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine
- Packaging
- 1mg
- Price
- $70
- Updated
- 2021/12/16
ARRY-380 Chemical Properties,Usage,Production
Description
Arry-380 analog was designed as an inhibitor of EGFR (ErbB1).
Uses
ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM.
Uses
Labelled ARRY-380. ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2.
target
p95-HER2
References
[1] s. l. moulder, v. borges, s. k. l. chia, t. baetz, e. barrett, j. garrus, k. guthrie, c. kass, e. laird, j. lyssikatos, f. marmsater, e. wallace. arry-380, a selective her2 inhibitor: from drug design to clinical evaluation. poster of aacr-nci-eortc, nov 12-16, 2011, san francisco, ca.
[2] victoria dinkel, deborah anderson, shannon winski, jim winkler, kevin koch and patrice lee. arry-380, a potent, small molecule inhibitor of erbb2, increases survival in intracranial erbb2+ xenograft models in mice. poster available at www.arraybiopharma.com
[3] s. chia, t. baetz, s. d'aloisio, g. fernetich, b. freeman, e. barrett, c. kass, j. kang, b. sajan, s. moulder, and j. garrus. a phase 1 study to assess the safety, tolerability and pharmacokinetics of arry-380 – an oral inhibitor of her2. cancer res 2009;69(24 suppl):abstract nr 5111.
ARRY-380 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ARRY-380 manufacturers
- Product
- ARRY-380 937265-83-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- Min98%
- Supply Ability
- 100kgs
- Release date
- 2020-10-27