CX-5461
- Product Name
- CX-5461
- CAS No.
- 1138549-36-6
- Chemical Name
- CX-5461
- Synonyms
- CS-1938;CX-5461;Pidanrulex;Pidnarulex;CX-5461 500MG;CX-5461/CX5461;CX-5461, >=98%;CX-5461 USP/EP/BP;CX-5461 Pidnarulex;CX-5461;CX 5461;CX5461
- CBNumber
- CB62561466
- Molecular Formula
- C27H27N7O2S
- Formula Weight
- 513.61
- MOL File
- 1138549-36-6.mol
CX-5461 Property
- Boiling point:
- 739.9±60.0 °C(Predicted)
- Density
- 1.45
- storage temp.
- +2C to +8C
- solubility
- insoluble in H2O; insoluble in EtOH; insoluble in DMSO
- form
- Light beige powder
- pka
- 8.53±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- 5.09265
- Product name
- RNA Polymerase I Inhibitor II, CX-5461 - CAS 1138549-36-6 - Calbiochem
- Packaging
- 10mg
- Price
- $280
- Updated
- 2024/03/01
- Product number
- 18392
- Product name
- CX-5461
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18392
- Product name
- CX-5461
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 18392
- Product name
- CX-5461
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $231
- Updated
- 2024/03/01
- Product number
- 18392
- Product name
- CX-5461
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $957
- Updated
- 2024/03/01
CX-5461 Chemical Properties,Usage,Production
Definition
ChEBI: CX-5461 is an organic heterotetracyclic compound that is 5-oxo-5H-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxylic acid substituted by a 4-methyl-1,4-diazepan-1-yl group at position 2 and in which the carboxy group at position 6 is substituted by a [(5-methylpyrazin-2-yl)methyl]nitrilo group. An inhibitor of ribosomal RNA (rRNA) synthesis which specifically inhibits RNA polymerase I-driven transcription of rRNA in several cancer cell lines. It is currently in phase I/II clinical trials for advanced hematologic malignancies and triple-negative breast cancer with BRCA1/2 mutation. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.7.6 (RNA polymerase) inhibitor. It is a diazepine, an organic heterotetracyclic compound, a member of pyrazines, a secondary carboxamide and a naphthyridine derivative.
General Description
A cell-permeable benzothiazole compound that selectively inhibits RNA polymerase I-mediated pre-rRNA transcription (IC50 = 142 nM in HCT-116), but not Pol II-mediated c-myc transcription, by preventing TAF SL1 and rDNA association). Effectively inhibits Pol I-dependent proliferation among 39 cancer cell lines (IC50<1 μM) in vitro and suppresses A375 (50 mg/kg/d p.o.) and MIA PaCa-2 (50 mg/kg/3d p.o.) tumor expansion in vivo.
Biological Activity
cx-5461 is a potent and orally bioavailable small-molecule inhibitor of rrna synthesis that specifically inhibits rna polymerase (pol) i-driven transcription with ic50 value of 142 nm. cx-5461 exhibits antiproliferative activity against human pancreatic tumor cells mia paca-2, human melanoma cells a375 and colorectal carcinoma cells hct-116 with ec50 values of 74, 58, and 167 nmol/l, respectively. [1].cx-5461 was revealed to inhibit pol i transcription via promoting the stabilization of p53. in addition, cx-5461 has been demonstrated to induce autophagy and senescence but not apoptosis in mia paca-2 and a375 cell lines.
Biochem/physiol Actions
Cell permeable: yes
in vivo
cx-5461 has shown to suppress tumor volume in both mia paca-2 and a375 derived xenograft mice models [1].
target
Pol I
References
[1] drygin d1, lin a, bliesath j, ho cb, o'brien se, proffitt c, omori m, haddach m, schwaebe mk, siddiqui-jain a, streiner n, quin je, sanij e, bywater mj,hannan rd, ryckman d, anderes k, rice wg. targeting rna polymerase i with an oral small molecule cx-5461 inhibits ribosomal rna synthesis and solid tumor growth. cancer res. 2011 feb 15;71(4):1418-30
CX-5461 Preparation Products And Raw materials
Raw materials
Preparation Products
CX-5461 Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 0757-86329057 18501085097
- Fax
- 010-89508210
- sales3.gd@hwrkchemical.com
- Country
- China
- ProdList
- 7583
- Advantage
- 55
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4647
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9872
- Advantage
- 52
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1494
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 400-6206333 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- +86-021-58975553
- Fax
- +86-021-58975554
- sales@cooperpharm.com
- Country
- China
- ProdList
- 1210
- Advantage
- 56
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2867
- Advantage
- 52
- Tel
- 0371-55932928 18937192232
- Fax
- 0086-0371-55932928
- 1282296214@qq.com
- Country
- China
- ProdList
- 496
- Advantage
- 55
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3421
- Advantage
- 58
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9767
- Advantage
- 58
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4121
- Advantage
- 55
- Tel
- 17764003753
- Fax
- 13669031409
- 2326587775@qq.com
- Country
- China
- ProdList
- 188
- Advantage
- 55
- Tel
- 17764003753
- Fax
- 13669031409
- 2326587775@qq.com
- Country
- China
- ProdList
- 188
- Advantage
- 55
- Tel
- +86-21-58447131
- Fax
- +86-21-61642470
- 1724405207@qq.com
- Country
- China
- ProdList
- 472
- Advantage
- 55
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 7059
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9254
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 021-50908862，442785678，326799392 18721037013
- Fax
- 021-50908862
- siyansales@126.com
- Country
- China
- ProdList
- 9638
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3868
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27322
- Advantage
- 60
- Tel
- 021-021-20242659 18930833303
- Fax
- +86 (21) 2024-2659
- order@changyanchem.com
- Country
- China
- ProdList
- 5008
- Advantage
- 55
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9604
- Advantage
- 55
- Tel
- 86-21-50817262
- Fax
- 86-21-57712035
- sales@lancrix.com
- Country
- China
- ProdList
- 1503
- Advantage
- 55
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14623
- Advantage
- 60
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9445
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29797
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
- ProdList
- 1844
- Advantage
- 58
- Tel
- 0550-5196001 15000891977
- Fax
- 0550-5196001
- wj520wjxby@126.com
- Country
- China
- ProdList
- 1831
- Advantage
- 55
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 18800375331
- Fax
- 021-50908862
- kangmansales@163.com
- Country
- China
- ProdList
- 7580
- Advantage
- 55
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28822
- Advantage
- 58
- Tel
- 028-85255396 18302801538
- Fax
- 028-85255396
- cdnovell@163.com
- Country
- China
- ProdList
- 2238
- Advantage
- 58
- Tel
- 021-37581181
- Fax
- 021-57456066
- sales@chem-mall.com
- Country
- China
- ProdList
- 10335
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 15503
- Advantage
- 58
- Tel
- 021-58958002 18930822973
- Fax
- 021-58958618
- xiaoyangw@gmail.com
- Country
- China
- ProdList
- 2129
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3237
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 025-025-51191215 18013836722
- Fax
- 025-51191215
- 2399235533@qq.com
- Country
- China
- ProdList
- 4933
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9730
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4698
- Advantage
- 58
- Tel
- 0571-85361029
- Fax
- 0571-85361029
- synstar518@163.com
- Country
- China
- ProdList
- 1991
- Advantage
- 58
View Lastest Price from CX-5461 manufacturers
- Product
- CX-5461 1138549-36-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-07-01