ChemicalBook > CAS DataBase List > 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
- Product Name
- 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
- CAS No.
- 865362-74-9
- Chemical Name
- 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
- Synonyms
- CS-1137;FR 180204;FR-0180204;LM-3319 FR 180204;ERK Inhibitor II, FR180204;FR 180204;FR-180204;FR180204;ERK Inhibitor II, FR180204 - CAS 865362-74-9 - Calbiochem;FR 180204, 98%, a potent and selective ATP-competitive inhibitor of ERK;5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine;1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-
- CBNumber
- CB72518957
- Molecular Formula
- C18H13N7
- Formula Weight
- 327.34
- MOL File
- 865362-74-9.mol
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5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Property
- Melting point:
- 267 °C
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- pka
- 7.19±0.50(Predicted)
- form
- Yellow solid
- color
- faint yellow to dark yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0320
- Product name
- FR 180204
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $158
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 328007
- Product name
- ERK Inhibitor II, FR180204
- Packaging
- 1mg
- Price
- $195.17
- Updated
- 2021/12/16
TCI Chemical
- Product number
- F1214
- Product name
- FR 180204
- Packaging
- 5MG
- Price
- $118
- Updated
- 2024/03/01
TCI Chemical
- Product number
- F1214
- Product name
- FR 180204
- Packaging
- 25MG
- Price
- $420
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15544
- Product name
- FR 180204
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
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5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Chemical Properties,Usage,Production
Uses
FR180204 has been used as ERK inhibitor:
- to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
- of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
- to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy
Definition
ChEBI: 5-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)-2H-pyrazolo[3,4-c]pyridazin-3-amine is a member of pyrazoles and a ring assembly.
Biochem/physiol Actions
FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).
storage
Store at +4°C
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Suppliers
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View Lastest Price from 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine manufacturers
Career Henan Chemical Co
- Product
- 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine 865362-74-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20