ChemicalBook > CAS DataBase List > 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

Product Name
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
CAS No.
865362-74-9
Chemical Name
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
Synonyms
CS-1137;FR 180204;FR-0180204;LM-3319 FR 180204;FR180204, 98%min;FR 180204 (FR180204;FR 180204, 10 mM in DMSO;FR180204/865362-74-9/98%;ERK Inhibitor II, FR180204;FR 180204;FR-180204;FR180204
CBNumber
CB72518957
Molecular Formula
C18H13N7
Formula Weight
327.34
MOL File
865362-74-9.mol
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5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Property

Melting point:
267 °C
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
pka
7.19±0.50(Predicted)
form 
Yellow solid
color 
faint yellow to dark yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
22-20
Safety Statements 
20/21
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0320
Product name
FR 180204
Purity
≥98% (HPLC)
Packaging
5mg
Price
$161.5
Updated
2025/07/31
Sigma-Aldrich
Product number
328007
Product name
ERK Inhibitor II, FR180204
Packaging
1mg
Price
$195.17
Updated
2021/12/16
TCI Chemical
Product number
F1381
Product name
FR 180204 [Optimized for Cell Culture]
Packaging
1MG
Price
$114
Updated
2025/07/31
TCI Chemical
Product number
F1214
Product name
FR 180204
Packaging
5MG
Price
$106
Updated
2025/07/31
TCI Chemical
Product number
F1214
Product name
FR 180204
Packaging
25MG
Price
$378
Updated
2025/07/31
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5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Chemical Properties,Usage,Production

Uses

FR180204 has been used as ERK inhibitor:

  • to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
  • of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
  • to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy

Definition

ChEBI: 5-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)-2H-pyrazolo[3,4-c]pyridazin-3-amine is a member of pyrazoles and a ring assembly.

Biochem/physiol Actions

FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).

in vivo

FR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss in collagen-induced arthritis mice[2].?In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves clinical parameters[4].

IC 50

ERK2: 0.14 μM (Ki); ERK1: 0.31 μM (Ki); ERK2: 0.33 μM (IC50); ERK1: 0.51 μM (IC50)

storage

Store at +4°C

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Suppliers

Americas 1 China 98 Europe 1 India 1 Japan 1 United Kingdom 1 United States 13 Global 116
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine manufacturers

Career Henan Chemical Co
Product
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine 865362-74-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-20

865362-74-9, 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamineRelated Search:

LY 294002 Hydrochloride MK-2206 2HCl 1,9-Pyrazoloanthrone SB 203580 SCH772984

  • 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
  • LM-3319 FR 180204
  • FR 180204
  • 1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-
  • 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine FR 180204
  • 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine
  • ERK Inhibitor II, FR180204
  • FR 180204, 98%, a potent and selective ATP-competitive inhibitor of ERK
  • FR 180204;FR-180204;FR180204
  • CS-1137
  • ERK Inhibitor II, FR180204 - CAS 865362-74-9 - Calbiochem
  • 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine USP/EP/BP
  • Apoptosis,Extracellular signal regulated kinases,FR-180204,Inhibitor,inhibit,ERK,FR 180204
  • FR-0180204
  • FR 180204, 10 mM in DMSO
  • FR180204, 98%min
  • FR180204/865362-74-9/98%
  • FR 180204 (FR180204
  • 865362-74-9
  • Inhibitors