5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

ChemicalBook > CAS DataBase List > 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

Product Name: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
CAS No.: 865362-74-9
Chemical Name: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
Synonyms: CS-1137;FR 180204;FR-0180204;LM-3319 FR 180204;ERK Inhibitor II, FR180204;FR 180204;FR-180204;FR180204;ERK Inhibitor II, FR180204 - CAS 865362-74-9 - Calbiochem;FR 180204, 98%, a potent and selective ATP-competitive inhibitor of ERK;5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine;1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-
CBNumber: CB72518957
Molecular Formula: C18H13N7
Formula Weight: 327.34
MOL File: 865362-74-9.mol

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5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Property

Melting point:: 267 °C
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
pka: 7.19±0.50(Predicted)
form: Yellow solid
color: faint yellow to dark yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22-20
Safety Statements: 20/21
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0320
Product name: FR 180204
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $158
Updated: 2024/03/01

Sigma-Aldrich

Product number: 328007
Product name: ERK Inhibitor II, FR180204
Packaging: 1mg
Price: $195.17
Updated: 2021/12/16

TCI Chemical

Product number: F1214
Product name: FR 180204
Packaging: 5MG
Price: $118
Updated: 2024/03/01

TCI Chemical

Product number: F1214
Product name: FR 180204
Packaging: 25MG
Price: $420
Updated: 2024/03/01

Cayman Chemical

Product number: 15544
Product name: FR 180204
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

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5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Chemical Properties,Usage,Production

Uses

FR180204 has been used as ERK inhibitor:

to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy

Definition

ChEBI: 5-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)-2H-pyrazolo[3,4-c]pyridazin-3-amine is a member of pyrazoles and a ring assembly.

Biochem/physiol Actions

FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).

storage

Store at +4°C

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine Suppliers

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View Lastest Price from 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine manufacturers

Career Henan Chemical Co

Product: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine 865362-74-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-20

865362-74-9, 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamineRelated Search:

MK-2206 2HCl 1,9-Pyrazoloanthrone SB 203580 SCH772984 LY 294002 HYDROCHLORIDE

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

LM-3319 FR 180204

FR 180204

1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine FR 180204

5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine

ERK Inhibitor II, FR180204

FR 180204, 98%, a potent and selective ATP-competitive inhibitor of ERK

FR 180204;FR-180204;FR180204

CS-1137

ERK Inhibitor II, FR180204 - CAS 865362-74-9 - Calbiochem

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine USP/EP/BP

Apoptosis,Extracellular signal regulated kinases,FR-180204,Inhibitor,inhibit,ERK,FR 180204

FR-0180204

865362-74-9

Inhibitors