PHT-427
- Product Name
- PHT-427
- CAS No.
- 1191951-57-1
- Chemical Name
- PHT-427
- Synonyms
- CS-303;CS-0223;PHT-427;PHT-427, >=98%;PHT-427;PHT 427;PHT-427 USP/EP/BP;PHT-427 (CS-0223);PHT-427 Akt Inhibitor XIV PHT427;Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem;4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
- CBNumber
- CB62561491
- Molecular Formula
- C20H31N3O2S2
- Formula Weight
- 409.61
- MOL File
- 1191951-57-1.mol
PHT-427 Property
- Melting point:
- 126-127 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
- Boiling point:
- 535.0±43.0 °C(Predicted)
- Density
- 1.162
- storage temp.
- +2C to +8C
- solubility
- Chloroform, Methanol (Slightly)
- form
- White solid
- pka
- 6.03±0.40(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 124032
- Product name
- Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem
- Packaging
- 10mg
- Price
- $154
- Updated
- 2023/06/20
- Product number
- 24188
- Product name
- PHT-427
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 24188
- Product name
- PHT-427
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $71
- Updated
- 2024/03/01
- Product number
- 24188
- Product name
- PHT-427
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 24188
- Product name
- PHT-427
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $311
- Updated
- 2024/03/01
PHT-427 Chemical Properties,Usage,Production
Uses
PHT-427 is a dual Akt and PDPK1 inhibitor with Ki of 2.7 μM and 5.2 μM, respectively.
Uses
PHT-427 is a pleckstrin homology domain inhibitor to Akt and PKB Kinase (PDPK1). It can also be used for therapeutic use and biological study of mathematical modeling and parametric analysis of nanoparticle encapsulation and controlled release of a hydrophobic kinase inhibitor PHT-427.
Biological Activity
pht-427 is an inhibitor of akt and pdpk1 (ki =2.7 μm and 5.2 μm, respectively).akt is a serine/threonine-specific protein kinase that plays a vital role in multiple cellular processes including glucose metabolism, apoptosis, cell proliferation, transcription and cell migration etc.in bxpc-3 cells, pht-427 showed inhibition upon akt function with ic50 value of 8.6±0.8 μm and for its downstream substrates. pht-427 reduced the akt phosphorylation on ser473 residue and did not decrease total akt protein level. pht-427 also inhibited p70s6k and gsk3β in a dose-dependent manner. [1][2]in scid (severe combined immunodeficiency) mice of bxpc-3 pancreatic cancer xenografts, administration of pht-427 exerted prominent antitumor activity that halted tumor growth. pht-427 in combination with erlotinib exhibited greater than additive antitumor activity in nsc lung cancer and with paclitaxel in breast cancer. [1][2]
Enzyme inhibitor
This orally bioavailable, dual Akt/PDPK1 inhibitor (F.Wt. = 409.61; CAS 1191951-57-1 and 1178893-77-0; Solubility (25°C): 80 mg/mL DMSO, <1 mg/mL Water), known systematically as 4-dodecyl-N-(1,3,4-thiadiazol-2- yl)benzenesulfonamide, targets Akt (also known as Protein Kinase B, or PKB) and 3-phosphoinositide-dependent protein kinase-1, with Ki of 2.7 μM and 5.2 μM, respectively. PHT-427 was designed to bind to the pleckstrin homology (PH) auto-inhibitory domains of the signal cascade protein kinase Akt.
storage
-20°C
References
1. meuillet ej, zuohe s, lemos r et al. molecular pharmacology and antitumor activity of pht-427, a novel akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. mol cancer ther. 2010 mar;9(3):706-17.2. moses sa, ali ma, zuohe s et al. in vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase b/akt. cancer res. 2009 jun 15;69(12):5073-81.
PHT-427 Preparation Products And Raw materials
Raw materials
Preparation Products
PHT-427 Suppliers
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View Lastest Price from PHT-427 manufacturers
- Product
- PHT-427 1191951-57-1
- Price
- US $60.00-600.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-10
- Product
- PHT-427 1191951-57-1
- Price
- US $1000.00-950.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-08-04