PHT-427

Product Name: PHT-427
CAS No.: 1191951-57-1
Chemical Name: PHT-427
Synonyms: CS-303;CS-0223;PHT-427;PHT-427, >=98%;PHT-427;PHT 427;PHT-427 USP/EP/BP;PHT-427 (CS-0223);PHT-427 Akt Inhibitor XIV PHT427;Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem;4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
CBNumber: CB62561491
Molecular Formula: C20H31N3O2S2
Formula Weight: 409.61
MOL File: 1191951-57-1.mol

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PHT-427 Property

Melting point:: 126-127 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
Boiling point:: 535.0±43.0 °C(Predicted)
Density: 1.162
storage temp.: +2C to +8C
solubility: Chloroform, Methanol (Slightly)
form: White solid
pka: 6.03±0.40(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 124032
Product name: Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem
Packaging: 10mg
Price: $154
Updated: 2023/06/20

Cayman Chemical

Product number: 24188
Product name: PHT-427
Purity: ≥98%
Packaging: 5mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 24188
Product name: PHT-427
Purity: ≥98%
Packaging: 10mg
Price: $71
Updated: 2024/03/01

Cayman Chemical

Product number: 24188
Product name: PHT-427
Purity: ≥98%
Packaging: 25mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 24188
Product name: PHT-427
Purity: ≥98%
Packaging: 50mg
Price: $311
Updated: 2024/03/01

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PHT-427 Chemical Properties,Usage,Production

Uses

PHT-427 is a dual Akt and PDPK1 inhibitor with Ki of 2.7 μM and 5.2 μM, respectively.

Uses

PHT-427 is a pleckstrin homology domain inhibitor to Akt and PKB Kinase (PDPK1). It can also be used for therapeutic use and biological study of mathematical modeling and parametric analysis of nanoparticle encapsulation and controlled release of a hydrophobic kinase inhibitor PHT-427.

Biological Activity

pht-427 is an inhibitor of akt and pdpk1 (ki =2.7 μm and 5.2 μm, respectively).akt is a serine/threonine-specific protein kinase that plays a vital role in multiple cellular processes including glucose metabolism, apoptosis, cell proliferation, transcription and cell migration etc.in bxpc-3 cells, pht-427 showed inhibition upon akt function with ic50 value of 8.6±0.8 μm and for its downstream substrates. pht-427 reduced the akt phosphorylation on ser473 residue and did not decrease total akt protein level. pht-427 also inhibited p70s6k and gsk3β in a dose-dependent manner. [1][2]in scid (severe combined immunodeficiency) mice of bxpc-3 pancreatic cancer xenografts, administration of pht-427 exerted prominent antitumor activity that halted tumor growth. pht-427 in combination with erlotinib exhibited greater than additive antitumor activity in nsc lung cancer and with paclitaxel in breast cancer. [1][2]

Enzyme inhibitor

This orally bioavailable, dual Akt/PDPK1 inhibitor (F.Wt. = 409.61; CAS 1191951-57-1 and 1178893-77-0; Solubility (25°C): 80 mg/mL DMSO, <1 mg/mL Water), known systematically as 4-dodecyl-N-(1,3,4-thiadiazol-2- yl)benzenesulfonamide, targets Akt (also known as Protein Kinase B, or PKB) and 3-phosphoinositide-dependent protein kinase-1, with Ki of 2.7 μM and 5.2 μM, respectively. PHT-427 was designed to bind to the pleckstrin homology (PH) auto-inhibitory domains of the signal cascade protein kinase Akt.

storage

-20°C

References

1. meuillet ej, zuohe s, lemos r et al. molecular pharmacology and antitumor activity of pht-427, a novel akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. mol cancer ther. 2010 mar;9(3):706-17.2. moses sa, ali ma, zuohe s et al. in vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase b/akt. cancer res. 2009 jun 15;69(12):5073-81.

PHT-427 Preparation Products And Raw materials

Raw materials

Preparation Products

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PHT-427 Suppliers

China 106 India 1 United Kingdom 2 United States 19 Global 128

AdooQ BioScience, LLC

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Target molecule Corp.

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InvivoChem

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Cckinase, Inc.

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Alchem Pharmtech,Inc.

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Aladdin Scientific

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View Lastest Price from PHT-427 manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: PHT-427 1191951-57-1
Price: US $60.00-600.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-10

Career Henan Chemical Co

Product: PHT-427 1191951-57-1
Price: US $1000.00-950.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-08-04

1191951-57-1, PHT-427Related Search:

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CS-303

Akt Inhibitor XIV - CAS 1191951-57-1 - Calbiochem

PHT-427

4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

CS-0223

4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide PHT 427

PHT-427 4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

PHT-427;PHT 427

PHT-427, >=98%

Benzenesulfonamide, 4-dodecyl-N-1,3,4-thiadiazol-2-yl-

PHT-427 USP/EP/BP

PHT-427 (CS-0223)

PHT-427 Akt Inhibitor XIV PHT427

1191951-57-1

C20H31N3O2S2

PI3K/Akt/mTOR

Akt

mTOR

PI3K

Inhibitors